35 research outputs found

    LTL pricing: Looking back to the future

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    Numerous LTL carriers struggled during the recent recession as customers demanded lower prices. This study is designed to qualitatively evaluate the data gathered from three industry segments regarding LTL pricing. Researchers used semi-structured interviews to conduct an in-depth investigation with over two dozen industry experts who represented shippers, carriers, and 3PLs. Interview transcripts were analyzed using a grounded theory coding technique. Five major themes emerged from the interview transcripts. These themes are used to describe possible future adjustments to industry pricing structure

    Roles and capabilities of the retail supply chain organization

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    Supply chain management (SCM) has become a critical strategic function in recent years. Research in the discipline has been focused toward the upstream side of the supply chain on functions such as warehousing, transportation, procurement and production. As power has shifted downstream toward retailers and their customers, SCM research has been slow to respond. This represents a significant gap, and a significant opportunity. Retailers face challenges that differ from those found in upstream suppliers and manufacturers. We present findings from a study of senior supply chain executives in the retail industry that focuses on the supply chain challenges of greatest importance to retailers, and the evolving capabilities used to address these issues

    LTA and LPS from periodontal pathogenic bacteria increase viral latent gene expression through activating intracellular signaling pathways.

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    <p>(A) HGF and PDLF cells were pre-treated with indicated concentrations of LTA from <i>S. aureus</i> or LPS from <i>P. gingivalis</i> for 24 h, then infected with purified KSHV (MOI∼3). Proteins expression was detected by immunoblots. (B–C) HGF were pre-treated with 10 µg/mL of LTA from <i>S. aureus</i> or LPS from <i>P. gingivalis</i> for 24 h, then treated with 10 µM of the MEK/MAPK inhibitor U0126 or NF-κB inhibitor Bay11-7082 for 1.5 h, respectively, followed by infection with KSHV. qRT-PCR was used to quantify <i>ORF73</i> (<i>Lana</i>) transcripts. Error bars represent the standard errors of the means for 3 independent experiments. ** = p<0.01.</p

    LTA and LPS from periodontal pathogenic bacteria increase heparan sulfate proteoglycans (HSPG) expression in HGF and PDLF.

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    <p>(A) HGF and PDLF cells were pre-treated with 10 µg/mL of LTA from <i>S. aureus</i> or LPS from <i>P. gingivalis</i> for 24 h, then proteins expression was detected by immunoblots. (B) HGF were treated as (A), and total HSPG expression was detected by IFA as described in Methods.</p
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