Thacker Mountain Radio

Hosted by Jim Dees. Guest author: Martin Amis. Guest musicians: Larkin Poe, Sarah Shook and the Disarmer

Thacker Mountain Radio

Hosted by Jim Dees. Guest authors: Leanne Shapton and Ken Wells

Thacker Mountain Radio

Hosted by Jim Dees. Guest Authors: Julia Claiborne Johnson and Ariel Lawhon

Thacker Mountain Radio

Hosted by Jim Dees. Guest authors: Rodney Jones and Hannah Tinti. Guest musician: Cody Rogers

Thacker Mountain Radio

Jim Dees, host. Featuring Kent Russell, David Vann, and Preston Lauterbach

Reading and Conversation

Jonathan Miles in conversation with Jim Dees

Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin

Recent genomic analyses of pathologically-defined tumor types identify “within-a-tissue” disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We performed an integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types, revealing a unified classification into 11 major subtypes. Five subtypes were nearly identical to their tissue-of-origin counterparts, but several distinct cancer types were found to converge into common subtypes. Lung squamous, head & neck, and a subset of bladder cancers coalesced into one subtype typified by TP53 alterations, TP63 amplifications, and high expression of immune and proliferation pathway genes. Of note, bladder cancers split into three pan-cancer subtypes. The multi-platform classification, while correlated with tissue-of-origin, provides independent information for predicting clinical outcomes. All datasets are available for data-mining from a unified resource to support further biological discoveries and insights into novel therapeutic strategies

They Write Among Us: New Stories and Essays from the Best of Oxford Writers

Edited by Jim Dees Jefferson Press (Paperback, $16.95, ISBN: 0971897417, 9/2003) An anthology of stories and essays from writers in Oxford, Mississippi, including Larry Brown, Tom Franklin, Beth Ann Fennelly, Willie Morris, and others.https://egrove.olemiss.edu/mwp_books/1420/thumbnail.jp

Thacker Mountain Radio

Jim Dees, host David Maraniss, guest author The Yalobushwhackers, house band Joseph Decosimo, Rachel Goodrick, visiting musician