A study on body mass index and its correlation with type 2 diabetes

Obesity and increases in body weight are among the most important risk factors for type 2 diabetes mellitus. Obesity contributes to the development of type 2 diabetes mellitus. Body mass index is also known as obesity index. Body mass index is a strong and independent risk factor for being diagnosed in cases of type 2 diabetes mellitus. There is a high risk of type 2 diabetes in those who have a higher body mass index. The present study has been done with the objective of finding correlation between BMI and type 2 diabetes

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age  6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score  652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

Notion of Algebraic Immunity and Its evaluation Related to Fast Algebraic Attacks

It has been noted recently that algebraic (annihilator) immunity alone does not provide sufficient resistance against algebraic attacks. In this regar

Optimization of critical process parameters for amylase production by Bacillus sp. using statistical approach (RSM)

The aim of this work was to optimize the process parameters through the statistical approach for the production of alpha amylase by Bacillus sp. in submerged fermentation (SMF). Initially critical physical and chemical process parameters influencing the enzyme production were identified by Plackett-Burman method (eleven variables, seven nutritional, two physical and two dummies) were analyzed. Then optimum levels of most influencing parameters affecting amylase production were obtained by CCD and results were analyzed by standard analysis of variance (ANOVA). The effect of interaction of physiochemical parameters on the amylase production (z axis) was studied by plotting three dimensional response surface curves against any two independent variables. A high similarity was observed between the predicted and experimental results, which reflected the accuracy and applicability of RSM to optimize the process for enzyme production. As a result of RSM the optimum values for starch concentration -0.65%, (NH4)2SO4 -0.55% and pH- 8.33. As a result of media optimization, a titre of 1, 22,000 U/L-1 was achieved. A total of 2.4 fold increase in enzyme activity was observed.</jats:p

Surface waves in fibre-reinforced anisotropic solid elastic media under the influence of gravity

AbstractThe aim of the present article is to investigate the surface waves in anisotropic, elastic solid medium under the influence of gravity. The theory of generalised surface waves has first been developed and then used to investigate particular cases of waves, viz., Stoneley, Rayleigh, and Love. The wave velocity equations have been obtained for different cases and are in well agreement with the corresponding classical result, when the effect of gravity, viscosity, and fibre-reinforced parameters of the material medium are ignored.</jats:p