3D QSAR ANALYSIS OF 2,4-DISUBSTITUTED 1,5-BENZODIAZEPINE DERIVATIVES AS CNS DEPRESSANTS

New 2,4-disubstituted-1,5-benzodiazepine derivatives containing different functional groups have been screened for their CNS depressant activity. The synthesized benzodiazepine derivatives were screened for CNS depressant activity using the actophotometer model for mice. QSAR studies of synthesized derivatives were performed on Vlife MDS 3.5 software. The data set for QSAR studies encompassed activities of 45 molecules and 252 descriptors calculated by Vlife MDS 3.5. The training set comprised of 36 molecules and test set of 9 molecules. QSAR equation revealed that some electronic, steric and liphophillic parameters have correlation with CNS depressant activity. The best equation was selected on basis of correlation coefficient (r 2 ) and predicitivity of equation