Levels of aminotransferases and lactate dehydrogenase in pregnant and preeclampsia fetuses

Preeclampsia results in uteroplacental insufficiency which causes hypoxia to the fetus. Hypoxia causes biochemical changes in the fetal and pregnant liver by altering the concentration of biochemical parameters in maternal and fetal blood. Purpose of the study: to determine the level of aminotransferases (ALT, AST) and lactate dehydrogenase in pregnant and fetal / neonatus blood of normal and preeclamptic pregnancy Material and methods: 80 pregnant women were included in the study, 40 of whom had normal pregnancies and 40 preeclamptic pregnancies with increased retardation (IUGR), in both groups blood was drawn from the cubic vein to determine AST, ALT and LDH in pregnant women and the fetus/neonatus. Pregnancy age is determined by the formula of recent menstruation and fetal biometrics. Results were determined by the Mann-Whitney U test for non-parametric numerical variables destroyed in the independent groups. Results: AST values in pregnant women with preeclampsia are higher compared to physiological pregnancies [U = 521,500, z = 6.717, p \u3c0.001]. ALT values in pregnant women with preeclampsia are higher than in physiological pregnant women [U = 554,000, z = 6,560, p \u3c0.001]. LDH values are higher in preeclamptic pregnancy compared to physiological pregnancy [U = 1131.500, z = 3.509, p \u3c0.001]. The AST values in fetal/neonatus blood with IUGR are higher than normal-growth fetal values [U = 1333,000, z = 2,454, p \u3c0.014]. ALT values in the fetus/neonate with IUGR are higher compared to the fetus with normal growth [U = 908,000, z = 4,698, p \u3c0.001]. LDH values in fetal/neonatus blood with IUGR are higher compared to fetuses with normal growth [U = 1203,000, z = 3.135, p \u3c0.002]. Conclusions: In preeclamptic pregnancy the values of AST, ALT and LDH are higher compared to physiological pregnancy. In fetal/neonatus with IUGR values of AST, ALT, LDH are higher compared to normal-growing fetus/neonatus

Incidence reproductive menstrual disorders and gaccthorea hyperprolactinemia

Hyperprolactinemia is endocrinology disorder of the hypothalamus-pituitary axis- gonade which manifests with high reproductive menstrual disorders and infertility.The purpose of the paper:The purpose of the paper was to analyze the incidence of menstrual reproductive disorders (amenorrhea, oligomenorrhea, polimenorrhea) and galacthorrhea in to hyperprolactinemia. Material and methodsThe study included 125 patients. In group N (with hyperprolactinemia) included 35 women with menstrual disorders, galactorrhea and infertility. In group K (with normoprolactinemia) included 90 women with menstrual disorders, galactorrhea and infertility. Results:The incidence of hyperprolactinemia N group was 28% (hyperprolactinemia = 44.77ng/ml) compared with group K with 72 % incidence (Hyperprolactinemia=8.83 ng/ml), which is statistical significance p\u3c0.0001. Amanorrhea incidence N group was 25.71 % (prolactenemia=74.49ng/ml) compared to group amanorrhea K values 5.56 % and frequency prolactenemia 14.22ng/ml is with statistical significance p \u3c0.0001. Oligomenorrhea incidence N group was 20% compared with the incidence of oligomenorrhea K groups with 7.78 % incidence. Polimenorrhea N group is presented with 11.43% incidence compared with the group K with 3.33 % incidence. Galactorrhea shown incidence 34.29% (prolactinemia =64.49ng/ml) N group compared to the values of K group with the incidence of 3.33% and (prolactenemia =15.06 ng/ml) that is with statistical signifikanc p \u3c0.0001. Statistical analyses are made through the paired t-test and unpaired t- test. Conclusion Menstrual disorders fertility (amenorrhea, oligomenorhea, polimenorrhea) and galactorrhea are measured with high incidence and statistical signifikance hyperprolactinemia compared with control group (normoprolactinemia)