Enhancement of prostacyclin generation by cicletanine (an in vivo investigation).

The effect of cicletanine, an antihypertensive drug, was studied in two in vivo models. It was demonstrated that the drug markedly affected the response of intravenously administered arachidonic acid in the rabbit. In this model a marked increase of 6-oxo-PGF1 alpha was observed when challenged by the intravenous injection of 50 micrograms/kg b.w. of arachidonic acid. In the rat model used for the study of platelet-vessel wall interaction, it was demonstrated that the inhibition of prostacyclin synthetase could be offset by cicletanine. These results indicate that the drug modulates the generation of prostacyclin and as such is capable of affecting the peripheral resistances which determine the level of the blood pressure.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Is a K+-prostacyclin interaction involved in the mechanism of action of some diuretic drugs?

SCOPUS: le.jinfo:eu-repo/semantics/publishe

Resveratrol inhibits the activity of equine neutrophil myeloperoxidase by a direct interaction with the enzyme

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Teaching Bioeconomics

Bioeconomics is a relatively young field that uses an expanded microeconomics to examine animal behavior, human behavior, and animal and human social institutions. A voluminous literature is rapidly accumulating. There are as yet no standard textbooks, but there are several excellent books and/or articles that can be used in combination with videos and other aids to make a course that students will enjoy and that teachers can use to advance the frontiers of scholarship in economics and biology. Copyright Springer 2005altruism, conflict, cooperation, evolution, game theory, institutions, rationality,