22 research outputs found

    Generation and Immunoresponsiveness of Transgenic Mice Expressing T Cell Localised MHC Class II

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    A General RNA Motif for Cellular Transfection

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    We have developed a selection scheme to generate nucleic acid sequences that recognize and directly internalize into mammalian cells without the aid of conventional delivery methods. To demonstrate the generality of the technology, two independent selections with different starting pools were performed against distinct target cells. Each selection yielded a single highly functional sequence, both of which folded into a common core structure. This internalization signal can be adapted for use as a general purpose reagent for transfection into a wide variety of cell types including primary cells

    Myeloid Differentiation Factor 88 Is Required for Cross-Priming In Vivo

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    Listeria

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