Prognostic Role of 14F7 Mab Immunoreactivity against N-Glycolyl GM3 Ganglioside in Colon Cancer

Purpose. To assess the prognostic role of 14F7 Mab immunoreactivity, against N-Glycolyl GM3 ganglioside, in patients with colon cancer (CC) and to evaluate the relationship between its expression and clinicopathological features. Methods. Paraffin-embedded specimens were retrospectively collected from 50 patients with CC operated between 2004 and 2008. 14F7 Mab staining was determined by immunohistochemistry technique and its relation with survival and clinicopathologic features was evaluated. Results. The reactivity of 14F7 Mab was detected in all cases. Most cases had high level of immunostaining (70%) that showed statistical correlation with TNM stage (P=0.025). In univariate survival analysis, level of 14F7 Mab immunoreactivity (P=0.0078), TNM Stage (P=0.0007) and lymphovascular invasion (0.027) were significant prognostic factors for overall survival. Among these variables, level of 14F7 Mab immunoreactivity  (HR=0.268; 95%  CI  0.078–0.920; P=0.036) and TNM stage (HR=0.249; 95%  CI   0.066–0.932; P=0.039) were independent prognostic factors on multivariate analysis. Conclusions. This study is the first approach on the prognostic significance of 14F7 Mab immunoreactivity in patients with colon adenocarcinoma and this assessment might be used in the prognostic estimate of CC, although further studies will be required to validate these findings

Resultados de la cirugía pulmonar en el Instituto Nacional de Oncología y Radiobiología de Cuba (2006-2007) Results from pulmonary surgery performed in Cuban National Institute of Oncology and Radiobiology (2006-2007)

INTRODUCCIÓN. Reducir la estadía en cuidados intensivos y la estadía hospitalaria posoperatoria en cirugía pulmonar, con una morbilidad y mortalidad mínimas, se ha convertido en una verdadera tendencia investigativa para la mayoría de los servicios de cirugía torácica en el mundo. Evaluar los resultados de calidad y eficacia en un servicio de cirugía torácica fue nuestro objetivo. MÉTODOS. En un período de 2 años se realizaron resecciones pulmonares consecutivas a través de una toracotomía y los pacientes fueron extubados en el salón de operaciones y enviados las primeras 24 h a una sala de cuidados progresivos. Los tubos torácicos fueron colocados con sello de agua y retirados al tercer día posoperatorio si no había fuga aérea y el drenaje era menor de 150 mL/día. Se utilizó un catéter peridural, que se retiró al segundo día posoperatorio. Se dio el alta al paciente el día que se retiró del tórax el último tubo. RESULTADOS. Se incluyeron 156 pacientes (hombres), con edad media de 58 años (rango, 21-87 años). Se realizó neumonectomía en 9 (6 %) y se empleó lobectomía y bilobectomía en 110 pacientes (71 %). Las resecciones extraanatómicas se emplearon para metastasectomías. Fueron extubados en el salón de operaciones 149 pacientes (96 %) y 112 (72 %) fueron enviados las primeras 24 h a una unidad de cuidados progresivos. Ocurrieron complicaciones en 28 pacientes (18 %) y la mortalidad operatoria fue del 5 % (8 pacientes). El promedio de estadía posoperatoria fue de 4 días (rango, 2-25 días). Noventa y nueve pacientes (64 %) abandonaron el hospital el cuarto día posoperatorio o antes. El 97 % señaló un grado de satisfacción excelente o bueno. CONCLUSIONES. La mayoría de los pacientes pudieron ser extubados inmediatamente en el salón de operaciones, fueron directamente a sala o necesitaron cuidados progresivos mínimos y se les dio el alta al tercer o cuarto día posoperatorio. La morbilidad y mortalidad fueron aceptables y la satisfacción al egreso y al seguimiento en consulta externa 2 semanas después fue alta. La técnica que permitió alcanzar estos resultados incluyó el uso sistemático del sello de agua, la retirada del catéter peridural el día 2 del posoperatorio y el manejo precoz de los tubos torácicos.<br>INTRODUCTION: To reduce intensive care stay and that of postoperative hospital stay in pulmonary surgery service with a minimal morbidity and mortality becomes in a real research trend for most of thoracic surgery service at world scale. Aim of this paper was to assess results of quality and effectiveness in a thoracic surgery service. METHODS: During a period of 2 years we performed consecutive pulmonary resections by thoracotomy and patients underwent extubation in operating room and referred during the first 24 hours to a progressive care ward. Thoracic tubes were placed with water seal and removed at third postoperative day if there was not an aerial escape and if drain was smaller than 150 mL/day. We used a epidural catheter removed at second postoperative day. Patient was discharged the same day of removed the last tube. RESULTS: At present study were included 156 patients (men) with a mean age of 58 years (rank, 21-78 years). In 9 of them a pneumonectomy was performed (6%) and lobectomy and bi-lobectomy in 110 patients (71%). Extra-anatomical resections were used for metastasectomies. One hundred ninety nine patients (96%) underwent extubation in operating room, and 112 of them (72%) were sending during the first hours to a progressive care unit. There were complications in 28 patients (18%), and operative mortality was of 5% (8 patients). Postoperative mean stay was of 4 days (rank, 2-25 days). Ninety nine patients (64%) were discharged at forth postoperative day or before. The 97% reported an excellent or good satisfaction degree. CONCLUSIONS: Most of patients could be immediately underwent extubation at operating room, they went directly to ward or needed minimal progressive cares and were discharged at third or fourth postoperative day. Morbidity and mortality were acceptable with a high level of satisfaction at discharge and at follow-up in ambulatory consultation 2 weeks after discharge. Techniques allow us to achieve these results included systematic use of water seal, removal of epidural catheter at 2nd postoperative day and early management of thoracic tubes