Radio-over-fiber using an optical antenna based on Rydberg states of atoms

We provide an experimental demonstration of a direct fiber-optic link for RF transmission ("radio-over-fiber") using a sensitive optical antenna based on a rubidium vapor cell. The scheme relies on measuring the transmission of laser light at an electromagnetically-induced transparency resonance that involves highly-excited Rydberg states. By dressing pairs of Rydberg states using microwave fields that act as local oscillators, we encoded RF signals in the optical frequency domain. The light carrying the information is linked via a virtually lossless optical fiber to a photodetector where the signal is retrieved. We demonstrate a signal bandwidth in excess of 1 MHz limited by the available coupling laser power and optical density. Our sensitive, non-metallic and readily scalable optical antenna for microwaves allows extremely low-levels of optical power ($\sim 1\, \mu$W) throughput in the fiber-optic link. It offers a promising future platform for emerging wireless network infrastructures

Modelling of laboratory data of bi-directional reflectance of regolith surface containing Alumina

Bidirectional reflectance of a surface is defined as the ratio of the scattered radiation at the detector to the incident irradiance as a function of geometry. The accurate knowledge of the bidirectional reflection function (BRF) of layers composed of discrete, randomly positioned scattering particles is very essential for many remote sensing, engineering, biophysical applications and in different areas of Astrophysics. The computations of BRF's for plane parallel particulate layers are usually reduced to solve the radiative transfer equation (RTE) by the existing techniques. In this work we present our laboratory data on bidirectional reflectance versus phase angle for two sample sizes of 0.3 and 1 $\mu m$ of Alumina for the He-Ne laser at 632.8 nm (red) and 543.5nm(green) wavelength. The nature of the phase curves of the asteroids depends on the parameters like- particle size, composition, porosity, roughness etc. In our present work we analyse the data which are being generated using single scattering phase function i.e. Mie theory considering particles to be compact sphere. The well known Hapke formula will be considered along with different particle phase function such as Mie and Henyey Greenstein etc to model the laboratory data obtained at the asteroid laboratory of Assam University.Comment: 5 pages, 5 figures [accepted for publication in Publications of the Astronomical Society of Australia (PASA) on 8 June, 2011

Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication

Gain-of-function (GOF) p53 mutations are observed frequently in most intractable human cancers and establish dependency for tumor maintenance and progression. While some of the genes induced by GOF p53 have been implicated in more rapid cell proliferation compared with p53-null cancer cells, the mechanism for dependency of tumor growth on mutant p53 is unknown. This report reveals a therapeutically targetable mechanism for GOF p53 dependency. We have shown that GOF p53 increases DNA replication origin firing, stabilizes replication forks, and promotes micronuclei formation, thus facilitating the proliferation of cells with genomic abnormalities. In contrast, absence or depletion of GOF p53 leads to decreased origin firing and a higher frequency of fork collapse in isogenic cells, explaining their poorer proliferation rate. Following genome-wide analyses utilizing ChIP-Seq and RNA-Seq, GOF p53–induced origin firing, micronuclei formation, and fork protection were traced to the ability of GOF p53 to transactivate cyclin A and CHK1. Highlighting the therapeutic potential of CHK1’s role in GOF p53 dependency, experiments in cell culture and mouse xenografts demonstrated that inhibition of CHK1 selectively blocked proliferation of cells and tumors expressing GOF p53. Our data suggest the possibility that checkpoint inhibitors could efficiently and selectively target cancers expressing GOF p53 alleles