Catalytic Asymmetric Synthesis of Carbocyclic C-nucleosides

Access to carbocyclic C-nucleosides (CC-Ns) is currently restricted. The few methods available to make CC-Ns suffer from long syntheses and poor modularity, hindering the examination of potentially important chemical space. Here we report an approach to CC-Ns which uses an asymmetric Suzuki-Miyaura type reaction as the key C-C bond forming step. After coupling the densely functionalized racemic bicyclic allyl chloride and heterocyclic boronic acids, the trisubstituted cyclopentenyl core is elaborated to RNA analogues via a hydroborylation-homologation-oxidation sequence. We demonstrate that the approach can be used to produce a variety of enantiomerically enriched CC-Ns, including a carbocyclic derivative of Showdomycin

Hard X-ray detection of the high redshift quasar 4C 71.07

BATSE/OSSE observations of the high redshift quasar 4C 71.07 indicate that this is the brightest and furthest AGN so far detected above 20 keV. BATSE Earth occultation data have been used to search for emission from 4C 71.07 from nearly 3 years of observation. The mean source flux over the whole period in the BATSE energy range 20-100 keV is (13.2 +/- 1.06) x 10^(-11) erg cm^(-2) s^(-1) corresponding to a luminosity of 2 x 10^(48) erg s^(-1). The BATSE light curve over the 3 years of observations shows several flare-like events, one of which (in January 1996) is associated with an optical flare (R=16.1) but with a delay of 55 days. The OSSE/BATSE spectral analysis indicates that the source is characterized by a flat power spectrum (Gamma about 1.1 - 1.3) when in a low state; this spectral form is consistent within errors with the ASCA and ROSAT spectra. This means that the power law observed from 0.1 to 10 keV extends up to at least 1 MeV but steepens soon after to meet EGRET high energy data. BATSE data taken around the January 1996 flare suggests that the spectrum could be steeper when the source is in a bright state. The nuF-nu representation of the source is typical of a low frequency peaked/gamma-ray dominated blazar, with the synchrotron peak in the mm-FIR band and the Compton peak in the MeV band. The BATSE and OSSE spectral data seem to favour a model in which the high energy flux is due to the sum of the synchrotron self-Compton and the external Compton contributions; this is also supported by the variability behaviour of the source.Comment: 19 pages, LaTeX, plus 4 .ps figures. accepted by Astrophysical Journa