Spindle Microtubules: Getting Attached at Both Ends

SummaryA recent study describes a novel role for the centrosomal protein Cep57 in attaching spindle microtubules to both kinetochores and centrosomes, suggesting similar mechanisms may be used for generating these two distinct linkages in mitosis

Sds22 regulates aurora B activity and microtubule-kinetochore interactions at mitosis

Sds22 defines protein phosphatase 1 location and function at kinetochores and subsequent activity of aurora B in mitosis

Propagating EUV disturbances in the solar corona : two-wavelength observations

Quasi-periodic EUV disturbances simultaneously observed in 171 Å and 195 Å TRACE bandpasses propagating outwardly in a fan-like magnetic structure of a coronal active region are analysed. Time series of disturbances observed in the different bandpasses have a relatively high correlation coefficient (up to about 0.7). The correlation has a tendency to decrease with distance along the structure: this is consistent with an interpretation of the disturbances in terms of parallel-propagating slow magnetoacoustic waves. The wavelet analysis does not show a significant difference between waves observed in different bandpasses. Periodic patterns of two distinct periods: 2-3 min and 5-8 min are detected in both bandpasses, existing simultaneously and at the same distance along the loop, suggesting the nonlinear generation of the second harmonics

Size of coronal structures in active stellar coronae from the detection of X-ray resonant scattering

We have analyzed high-resolution X-ray spectra of a large sample of active stars observed with the High Energy Transmission Grating Spectrometer on Chandra in order to investigate the properties of optical thickness of the coronal plasma. The analysis of Lyman series lines arising from hydrogen-like oxygen and neon ions shows in the coronae of the active RS CVn-type binaries II Peg and IM Peg significant decrements in the Ly alpha/Ly beta ratios as compared with theoretical predictions and with the same ratios observed in similar active binaries. We interpret these depletions in terms of resonance scattering of line photons out of the line-of-sight. These observations present the first strong evidence for this effect in active stellar coronae. The net line photon loss implies a non-uniform and asymmetric surface distribution of emitting structures on these stars. Escape probability arguments imply typical line-of-sight sizes of the coronal structures that dominate the X-ray emission of 10(10) cm at temperatures of 3 x 10(6) K and 10(10) cm at 10(7) K. These sizes are an order of magnitude larger than predicted by simple quasi-static coronal loop models, but are still very small compared to the several 10(11) cm radii of the stars

Management of Elbow Dislocations in the National Football League.

Background: Although much literature exists regarding the treatment and management of elbow dislocations in the general population, little information is available regarding management in the athletic population. Furthermore, no literature is available regarding the postinjury treatment and timing of return to play in the contact or professional athlete. Purpose: To review the clinical course of elbow dislocations in professional football players and determine the timing of return to full participation. Study Design: Case series; Level of evidence, 4. Methods: All National Football League (NFL) athletes with elbow dislocations from 2000 through 2011 who returned to play during the season were identified from the NFL Injury Surveillance System (NFL ISS). Roster position, player activity, use of external bracing, and clinical course were reviewed. Mean number of days lost until full return to play was determined for players with elbow dislocations who returned in the same season. Results: From 2000 to 2011, a total of 62 elbow dislocations out of 35,324 injuries were recorded (0.17%); 40 (64.5%) dislocations occurred in defensive players, 12 (19.4%) were in offensive players; and 10 (16.1%) were during special teams play. Over half of the injuries (33/62, 53.2%) were sustained while tackling, and 4 (6.5%) patients required surgery. A total of 47 (75.8%) players who sustained this injury were able to return in the same season. For this group, the mean number of days lost in players treated conservatively (45/47) was 25.1 days (median, 23.0 days; range, 0.0-118 days), while that for players treated operatively (2/47) was 46.5 days (median, 46.5 days; range, 29-64 days). Mean return to play based on player position was 25.8 days for defensive players (n = 28; median, 21.5 days; range, 3.0-118 days), 24.1 days for offensive players (n = 11; median, 19 days; range, 2.0-59 days), and 25.6 days for special teams players (n = 8; median, 25.5 days; range, 0-44 days). Conclusion: Elbow dislocations comprise less than a half of a percent of all injuries sustained in the NFL. Most injuries occur during the act of tackling, with the majority of injured athletes playing a defensive position. Players treated nonoperatively missed a mean of 25.1 days, whereas those managed operatively missed a mean of 46.5 days

The approach to thermalization in the classical phi^4 theory in 1+1 dimensions: energy cascades and universal scaling

We study the dynamics of thermalization and the approach to equilibrium in the classical phi^4 theory in 1+1 spacetime dimensions. At thermal equilibrium we exploit the equivalence between the classical canonical averages and transfer matrix quantum traces of the anharmonic oscillator to obtain exact results for the temperature dependence of several observables, which provide a set of criteria for thermalization. We find that the Hartree approximation is remarkably accurate in equilibrium. The non-equilibrium dynamics is studied by numerically solving the equations of motion in light-cone coordinates for a broad range of initial conditions and energy densities.The time evolution is described by several stages with a cascade of energy towards the ultraviolet. After a transient stage, the spatio-temporal gradient terms become larger than the nonlinear term and a stage of universal cascade emerges.This cascade starts at a time scale t_0 independent of the initial conditions (except for very low energy density). Here the power spectra feature universal scaling behavior and the front of the cascade k(t) grows as a power law k(t) sim t^alpha with alpha lesssim 0.25. The wake behind the cascade is described as a state of Local Thermodynamic Equilibrium (LTE) with all correlations being determined by the equilibrium functional form with an effective time dependent temperatureTeff(t) which slowly decreases as sim t^{-alpha}.Two well separated time scales emerge while Teff(t) varies slowly, the wavectors in the wake with k < k(t) attain LTE on much shorter time scales.This universal scaling stage ends when the front of the cascade reaches the cutoff at a time t_1 sim a^{-1/alpha}. Virialization starts to set much earlier than LTE. We find that strict thermalization is achieved only for an infinite time scale.Comment: relevance for quantum field theory discussed providing validity criteria. To appear in Phys. Rev.

An Experimental Investigation into the Effect of Flap Angles for a Piezo-Driven Wing

This article presents a comparison of results from six degree of freedom force and moment measurements and Particle Image Velocimetry (PIV) data taken on the Air Force Institute of Technology\u27s (AFIT) piezoelectrically actuated, biomimetically designed Hawkmoth, Manduca Sexta, class engineered wing, at varying amplitudes and flapping frequencies, for both trimmed and asymmetric flapping conditions to assess control moment changes. To preserve test specimen integrity, the wing was driven at a voltage amplitude 50% below the maximum necessary to achieve the maximal Hawkmoth total stroke angle. 86 and 65 stroke angles were achieved for the trimmed and asymmetric tests respectively. Flapping tests were performed at system structural resonance, and at 10% off system resonance at a single amplitude, and PZT power consumption was calculated for each test condition. Two-dimensional PIV visualization measurements were taken transverse to the wing planform, recorded at the mid-span, for a single frequency and amplitude setting, for both trimmed and asymmetric flapping to correlate with the 6-DoF balance data. Linear velocity data was extracted from the 2-D PIV imagery at 1/2 and 1 chord locations above and below the wing, and the mean velocities were calculated for four separate wing phases during the flap cycle. The mean forces developed during a flap cycle were approximated using a modification of the Rankine-Froude axial actuator disk model to calculate the transport of momentum flux as a measure of vertical thrust produced during a static hover flight condition. Values of vertical force calculated from the 2-D PIV measurements were within 20% of the 6-DOF force balance experiments. Power calculations confirmed flapping at system resonance required less power than at off resonance frequencies, which is a critical finding necessary for future vehicle design considerations

Porous Microspheres for Drug Delivery and Methods for Making Same

Controlled release drug delivery systems comprised of spherical microporous polymeric network of interconnecting channels containing pore incorporated drugs or other agents wherein the drugs or agents are confined within the pore channel are described. Also disclosed are processing parameters in connection with the novel method of the invention for obtaining drug delivery systems especially suited for parenteral as well as oral administration