38 research outputs found
Multifractal Scaling, Geometrical Diversity, and Hierarchical Structure in the Cool Interstellar Medium
Multifractal scaling (MFS) refers to structures that can be described as a
collection of interwoven fractal subsets which exhibit power-law spatial
scaling behavior with a range of scaling exponents (concentration, or
singularity, strengths) and dimensions. The existence of MFS implies an
underlying multiplicative (or hierarchical, or cascade) process. Panoramic
column density images of several nearby star- forming cloud complexes,
constructed from IRAS data and justified in an appendix, are shown to exhibit
such multifractal scaling, which we interpret as indirect but quantitative
evidence for nested hierarchical structure. The relation between the dimensions
of the subsets and their concentration strengths (the "multifractal spectrum'')
appears to satisfactorily order the observed regions in terms of the mixture of
geometries present: strong point-like concentrations, line- like filaments or
fronts, and space-filling diffuse structures. This multifractal spectrum is a
global property of the regions studied, and does not rely on any operational
definition of "clouds.'' The range of forms of the multifractal spectrum among
the regions studied implies that the column density structures do not form a
universality class, in contrast to indications for velocity and passive scalar
fields in incompressible turbulence, providing another indication that the
physics of highly compressible interstellar gas dynamics differs fundamentally
from incompressible turbulence. (Abstract truncated)Comment: 27 pages, (LaTeX), 13 figures, 1 table, submitted to Astrophysical
Journa
The Cognitive Impact of the ANK3 Risk Variant for Bipolar Disorder: Initial Evidence of Selectivity to Signal Detection during Sustained Attention
BACKGROUND: Abnormalities in cognition have been reported in patients with Bipolar Disorder (BD) and their first degree relatives, suggesting that susceptibility genes for BD may impact on cognitive processes. Recent genome-wide genetic studies have reported a strong association with BD in a single nucleotide polymorphism (SNP) (rs10994336) within ANK3, which codes for Ankyrin 3. This protein is involved in facilitating the propagation of action potentials by regulating the assembly of sodium gated ion channels. Since ANK3 influences the efficiency of transmission of neuronal impulses, allelic variation in this gene may have widespread cognitive effects. Preclinical data suggest that this may principally apply to sequential signal detection, a core process of sustained attention. METHODOLOGY/PRINCIPAL FINDINGS: One hundred and eighty-nine individuals of white British descent were genotyped for the ANK3 rs10994336 polymorphism and received diagnostic interviews and comprehensive neurocognitive assessment of their general intellectual ability, memory, decision making, response inhibition and sustained attention. Participants comprised euthymic BD patients (n = 47), their unaffected first-degree relatives (n = 75) and healthy controls (n = 67). The risk allele T was associated with reduced sensitivity in target detection (p = 0.0004) and increased errors of commission (p = 0.0018) during sustained attention regardless of diagnosis. We found no effect of the ANK3 genotype on general intellectual ability, memory, decision making and response inhibition. CONCLUSIONS/SIGNIFICANCE: Our results suggest that allelic variation in ANK3 impacts cognitive processes associated with signal detection and this mechanism may relate to risk for BD. However, our results require independent replication and confirmation that ANK3 (rs10994336) is a direct functional variant
Journal of Thrombosis and Haemostasis, 1: 239–242 ORIGINAL ARTICLE
The association between birth weight and plasma fibrinogen is abolished after the elimination of genetic influence