In vitro antitumour activity of organotin(IV) derivatives of salicylic acid and related compounds

Chapter 17info:eu-repo/semantics/publishe

Organotin compounds of the type R2Sn(X-A-B-Y) with antitumor properties

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In vitro activity of a series of octahedral diorganotin complexes against two human cell lines, MCF-7, a mammary tumour, and WiDr, a colon carcinoma

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Synthesis, Characterization and Antitumour Activity of Some Butyltin(IV) Cysteaminates and N,N-Dimethylcysteaminates.

The synthesis and characterization of four di- and tri-n-butyltin cysteaminates and N,N-dimethylcysteaminates and three protonated / quaternized derivatives are reported. They all exhibit moderate or high in vitro cytotoxic activity. Six of seven compounds presented in this work are more active than cisplatin, etoposide and 5-fluorouracil, but less active than methotrexate and doxorubicin.Journal Articleinfo:eu-repo/semantics/publishe

No easy way to exterminate 'superbugs' at the dawn of the third millennium

SCOPUS: ed.jinfo:eu-repo/semantics/publishe

Synthesis, characterization and in vitro cytotoxicity of palladium(II) complexes with mixed ligands: X-ray diffraction study of C31H36ClNPPdS2

Pd(II) complexes with organophosphines and dithiocarbamates derivatives of α-amino acids were synthesized by reacting N,N-dicyclohexyldithiocarbamate (DCHDTC, compounds 1–3) and N-methylcyclohexyldithiocarbamate (MCHDTC, compounds 4–6) with (R3P)2PdCl2 (R = Ph, o-tolyl, Ph2Cl) in a 1:1 molar ratio. The complexes were characterized by elemental analyses, FT-IR, multinuclear (1H, 13C and 31P) NMR and single X-ray crystallography, showing that the dithiocarbamate acts as a bidentate ligand and binds to Pd(II) via two sulfur atoms, resulting in a square planar geometry around Pd(II). The cytotoxicity of compounds 2, 3 and 4 was determined in vitro against six human tumour cell lines, MCF7, EVSA-T, WIDR, IGROV, M19 MEL, A498 and H226. Compounds 3 and 4 showed a moderate to low cytotoxicity, whereas compound 2 exhibited a very low cytotoxicity. The results of antifungal assays showed that compounds 1–6 possess antifungal activity against Fusarium moniliformes, Fusarium saolani, Mucor sp. Aspergillus niger and Aspergillus fumigatus. The anti-inflammatory screening results of 1–6 are quite similar to those observed for the standard drug Declofenac at 10 mg kg−1, which inhibited the odema by 74% after 4 h. Copyright © 2007 John Wiley & Sons, Ltd.FLWINinfo:eu-repo/semantics/publishe

Preparation of organotin derivatives of terebic acid and compositions containing these compounds useful as antitumor agents

Eur. Pat. Publ. EP 0 848,008 A 1, Appl. 96/203495.5, 10/12/96info:eu-repo/semantics/publishe

Aromatic fluorine-containing organotin compounds and anti-tumour compositions

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Triphenyltin ortho-aminophenyl- and 2-pyridyl-thiolates: synthesis and in vitro antitumour activity.

The synthesis, spectroscopic characterization and in vitro antitumour activity of two triorganotin compounds, triphenyltin ortho-aminophenylthiolate (1) and triphenyltin 2-pyridylthiolate, compound (2) are reported. The structure of 1 is confirmed by X-ray diffraction, with the tin atom in a distorted tetrahedral geometry because of monodentate coordination, as a thiolate (Sn-S 2.431(2) A), of the ortho-aminophenylthiolate ligand. The in vitro antitumour activities of 1 and 2, against a number of cell lines, are comparable to those exhibited by methotrexate and doxorubicin, and higher than those of carboplatin and cisplatin.Journal Articleinfo:eu-repo/semantics/publishe

Aromatic fluorine-containing organotin compounds and antitumour compositions

US Patent, 5,559,147, Sep. 24, 1996info:eu-repo/semantics/publishe