21 research outputs found

    ANESTHESIE EN CHIRURGIE CARDIAQUE PEDIATRIQUE CHEZ L'ENFANT DE MOINS DE 10 KG

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    SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe

    Heart block following propofol in a child

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    We present the case of a nine-year-old boy afflicted with Ondine's curse, who developed complete atrioventricular heart block after a single bolus of propofol for induction of anaesthesia for strabismus surgery. Ondine's curse, the other name for congenital central hypoventilation syndrome, is characterized by a generalized disorder of autonomic function. Propofol has no effect on the normal atrioventricular conduction system in humans but it reduces sympathetic activity and can highly potentiate other vagal stimulation factors. Heart block has been documented after propofol bolus use in adults but, to our knowledge, not in children. It would appear that propofol is not a good choice for anaesthesia in congenital central hypoventilation syndrome.SCOPUS: ar.jFLWINinfo:eu-repo/semantics/publishe

    Remifentanil versus morphine-midazolam premedication on the quality of endotracheal intubation in neonates: A noninferiority randomized trial

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    Objective To compare remifentanil and morphine-midazolam for use in nonurgent endotracheal intubation in neonates. Study design In this prospective noninferiority randomized trial, newborns of gestational age ?28 weeks admitted in the neonatal intensive care unit requiring an elective or semielective endotracheal intubation were divided into 2 groups. One group (n = 36) received remifentanil (1 ?g/kg), and the other group (n = 35) received morphine (100 ?g/kg) and midazolam (50 ?g/kg) at a predefined time before intubation (different in each group), to optimize the peak effect of each drug. Both groups also received atropine (20 ?g/kg). The primary outcome was to compare the conditions of intubation, and the secondary outcome was to compare the duration of successful intubation, physiological variables, and pain scores between groups for first and second intubation attempts. Adverse events and neurologic test data were reported. Results Intubation with remifentanil was not inferior to that with morphine-midazolam. At the first attempted intubation, intubation conditions were poor in 25% of the remifentanil group and in 28.6% of the morphine-midazolam group (P =.471). For the second attempt, conditions were poor in 28.6% of the remifentanil group, compared with 10% of the morphine-midazolam group (P =.360). The median time to successful intubation was 33 seconds (IQR, 24-45 seconds) for the remifentanil group versus 36 seconds (IQR, 25-59 seconds) for the morphine-medazolam group (P =.359) at the first attempt and 45 seconds (IQR, 35-64 seconds) versus 56 seconds (IQR, 44-68 seconds), respectively, for the second attempt (P =.302). No significant between-group difference was reported for hypotension, bradycardia, or adverse events. Conclusion In our cohort, remifentanil was at least as effective as the morphine-midazolam regimen for endotracheal intubation. Thus, premedication using this very-short-acting opioid can be considered in urgent intubations and is advantageous in rapid extubation. 2014 The Authors.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

    Anaesthesia and orphan disease: A 26-year-old patient with achondroplasia

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    SCOPUS: le.jinfo:eu-repo/semantics/publishe
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