Vulnerability assessment of the karst aquifer feeding the Pertuso Spring (Central Italy): comparison between different applications of COP method

Karst aquifers vulnerability assessment and mapping are important tools for improved sustainable management and protection of karst groundwater resources. In this paper, in order to estimate the vulnerability degree of the karst aquifer feeding the Pertuso Spring in Central Italy, COP method has been applied starting from two different discretization approaches: using a polygonal layer and the Finite Square Elements (FSE). Therefore, the hydrogeological catchment basin has been divided into 72 polygons, related to the outcropping lithology and the karst features. COP method has been applied to a single layer composed by all these polygons. The results of this study highlight vulnerability degrees ranging from low to very high. The maximum vulnerability degree is due to karst features responsible of high recharge and high hydraulic conductivity. Comparing the vulnerability maps obtained by both methodologies it is possible to say that the traditional discretization approach seems to overestimate the vulnerability of the karst aquifer feeding the Pertuso Spring. Between the two different approaches of COP method, the proposed polygonal discretization of the hydrogeological basin seems to be more suitable to small areas, such as the Pertuso Spring hydrogeological basin, than the traditional grid mapping

Essential connectedness and the rigidity problem for Gaussian symmetrization

We provide a geometric characterization of rigidity of equality cases in Ehrhard's symmetrization inequality for Gaussian perimeter. This condition is formulated in terms of a new measure-theoretic notion of connectedness for Borel sets, inspired by Federer's definition of indecomposable current.Comment: 38 page

Comprehensive analysis of the membrane phosphoproteome regulated by oligogalacturonides in Arabidopsis thaliana

Early changes in the Arabidopsis thaliana membrane phosphoproteome in response to oligogalacturonides (OGs), a class of plant damage-associated molecular patterns (DAMPs), were analyzed by two complementary proteomic approaches. Differentially phosphorylated sites were determined through phosphopeptide enrichment followed by LC-MS/MS using label-free quantification; differentially phosphorylated proteins were identified by 2D-DIGE combined with phospho-specific fluorescent staining (phospho-DIGE). This large-scale phosphoproteome analysis of early OG-signaling enabled us to determine 100 regulated phosphosites using LC-MS/MS and 46 differential spots corresponding to 34 pdhosphoproteins using phospho-DIGE. Functional classification showed that the OG-responsive phosphoproteins include kinases, phosphatases and receptor-like kinases, heat shock proteins (HSPs), reactive oxygen species (ROS) scavenging enzymes, proteins related to cellular trafficking, transport, defense and signaling as well as novel candidates for a role in immunity, for which elicitor-induced phosphorylation changes have not been shown before. A comparison with previously identified elicitor-regulated phosphosites shows only a very limited overlap, uncovering the immune-related regulation of 70 phosphorylation sites and revealing novel potential players in the regulation of elicitor-dependent immunity

The effects of decoupling on Italian COP sector: an ex-post evaluation

One of the main objectives of the 2003 CAP reform was that to enhance farm competitiveness and make farmers able to catch market signals and adjust their production level and specialization accordingly. The aim of the paper is to evaluate the effects of decoupling in Italy COP sector comparing the estimated results of some structural and economic indicators of a sample of farms before and after the 2003 reform using data from the Italian Institute of Statistics and of the Italian Farm Accountancy Data Network (FADN). The analysis shows an improvement of income in farms that kept COP production specialization through the years under study. At the same time, farms that opted for a different specialisation in the post reform period improved their economic performance. All this suggests that coupled support had become a constraint rather than an opportunity and that the 2003 reform, decoupling farm support from production, has contributed to a more efficient and market-oriented COP sector in Italy.CAP, decoupling, Italian FADN, COP sector, Agricultural and Food Policy, Q18,

A Sardinian early 1st millennium BC bronze axe from Motya

An Iron Age bronze axe was found in Motya (Sicily, Italy) in a prehistoric layer dating from the 10th century BC underneath the 4th century BC patrician residency known as “Casa dei mosaici”. The axe belongs to the double-looped socketed type well known in central Mediterranean in the time span 1200-900 BC, and it is comparable with some coeval Sardinian specimens. The bronze has been characterised using the backscattering electron signal of a SEM (Scanning Electron Microscope) and EDX (Energy Dispersive X-ray Spectroscopy). The resulting composition of the metal alloy is Cu-Sn-As with an addition of Pb in some specific spots

Diagnostic imaging and CEUS findings in a rare case of Desmoid-type fibromatosis. A case report

Desmoid-type fibromatosis (DF), also known as aggressive fibromatosis, is a locally aggressive benign fibroblastic neoplasm that can infiltrate or recur but cannot metastasize. It is rare, with an estimated annual incidence of two to four new cases per million people. Most DFs occur sporadically, but it may also be associated with the hereditary syndrome familial adenomatous polyposis. Treatment is necessary when the disease is symptomatic, especially in case of compression of critical structures. When possible, surgical resection is the treatment of choice; however, recurrence is common. Due to the high rate of recurrence, imaging plays an important role not only in diagnosis, but also in the management of DF. Although there are a number of studies describing CT and MRI findings of DF, there is no description of contrast-enhanced ultrasound findings

Microglia Control Neuronal Network Excitability via BDNF Signalling

Microglia-neuron interactions play a crucial role in several neurological disorders characterized by altered neural network excitability, such as epilepsy and neuropathic pain. While a series of potential messengers have been postulated as substrates of the communication between microglia and neurons, including cytokines, purines, prostaglandins, and nitric oxide, the specific links between messengers, microglia, neuronal networks, and diseases have remained elusive. Brain-derived neurotrophic factor (BDNF) released by microglia emerges as an exception in this riddle. Here, we review the current knowledge on the role played by microglial BDNF in controlling neuronal excitability by causing disinhibition. The efforts made by different laboratories during the last decade have collectively provided a robust mechanistic paradigm which elucidates the mechanisms involved in the synthesis and release of BDNF from microglia, the downstream TrkB-mediated signals in neurons, and the biophysical mechanism by which disinhibition occurs, via the downregulation of the K+-Cl− cotransporter KCC2, dysrupting Cl−homeostasis, and hence the strength of GABAA- and glycine receptor-mediated inhibition. The resulting altered network activity appears to explain several features of the associated pathologies. Targeting the molecular players involved in this canonical signaling pathway may lead to novel therapeutic approach for ameliorating a wide array of neural dysfunctions