1,057 research outputs found
The Influence of Organizational Culture, Leadership Style and Organizational Commitment in Improving Employee Performance
The university is one of the containers, where the provision of service facilities and provide human resource capacity to the identical community of various sciences. This study aims to determine to know the influence of Organizational Culture, Leadership Style and Organizational Commitment in improving job performance Employees consisting of permanent and non permanent lecturer at Unpad Unpad Dili Timor-Leste. The type of research used in this study is quantitative approach. The quantitative approach is based on the approach done by recording and analyzing the data of the research results by using statistical calculations supported by literature study and data collection tool in the form of questionnaires distributed to permanent and non permanent lecturers at Unpad Unpad Dili Timor-Leste. The results showed that partially organizational culture, positive and significant effect on employee performance, leadership style has a positive and significant impact on employee performance, as well as organizational commitment have a positive and significant impact on employee performance
ΠΠΎΠΌΡΠ½ΡΠΊΠ°ΡΠΈΠ²Π½ΠΎ-ΠΌΠ°Π½ΡΠΏΡΠ»ΡΡΠΈΠ²Π½Ρ ΡΠΈΠ½Π½ΠΈΠΊΠΈ ΠΏΠΎΠ»ΡΡΠΈΡΠ½ΠΎΡ ΠΌΠΎΡΠΈΠ²Π°ΡΡΡ
ΠΠ½Π°Π»ΡΠ·ΡΡΡΡΡΡ ΠΎΡΠ½ΠΎΠ²Π½Ρ ΠΊΠΎΠΌΡΠ½ΡΠΊΠ°ΡΠΈΠ²Π½ΠΎ-ΠΌΠ°Π½ΡΠΏΡΠ»ΡΡΠΈΠ²Π½Ρ ΡΠΈΠ½Π½ΠΈΠΊΠΈ ΠΏΠΎΠ»ΡΡΠΈΡΠ½ΠΎΡ ΠΌΠΎΡΠΈΠ²Π°ΡΡΡ, ΡΠΊΡ Π²ΠΈΠ·Π½Π°ΡΠΈΠ»ΠΈ ΡΠΎΡΠΌΡΠ²Π°Π½Π½Ρ Π²ΡΠ΄ΠΏΠΎΠ²ΡΠ΄Π½ΠΈΡ
Π΅Π»Π΅ΠΊΡΠΎΡΠ°Π»ΡΠ½ΠΈΡ
ΡΠ΅ΠΎΡΡΠΉ. ΠΠΎΠΊΡΠ΅ΠΌΠ°, ΡΠ²Π°Π³Ρ ΠΏΡΠΈΠ΄ΡΠ»Π΅Π½ΠΎ ΠΌΠ΅ΡΠ°ΡΠΎΡΠΈΡΠ½ΠΈΠΌ ΠΌΠΎΠ΄Π΅Π»ΡΠΌ, ΠΏΠΎΠ»ΡΡΠΈΠΊΠΎ-ΠΊΠΎΠΌΡΠ½ΡΠΊΠ°ΡΠΈΠ²Π½ΡΠΉ ΡΠ΅ΠΎΡΡΡ, ΡΠ΅ΠΎΡΡΡ ΠΌΠΎΡΠΈΠ²ΠΎΠ²Π°Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ»ΡΡΠΈΡΠ½ΠΎΠ³ΠΎ ΠΌΠΈΡΠ»Π΅Π½Π½Ρ, ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΈΠΌ (ΠΌΠ°ΡΠΊΠ΅ΡΠΈΠ½Π³ΠΎΠ²ΠΈΠΌ) ΡΠ΅ΠΎΡΡΡΠΌ ΡΠ° ΡΠ½.ΠΠ½Π°Π»ΠΈΠ·ΠΈΡΡΡΡΡΡ ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ ΠΊΠΎΠΌΠΌΡΠ½ΠΈΠΊΠ°ΡΠΈΠ²Π½ΠΎ-ΠΌΠ°Π½ΠΈΠΏΡΠ»ΡΡΠΈΠ²Π½ΡΠ΅ ΡΠ°ΠΊΡΠΎΡΡ ΠΏΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΒΠΊΠΎΠΉ ΠΌΠΎΡΠΈΠ²Π°ΡΠΈΠΈ, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΠ»ΠΈ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠΈΡ
ΡΠ»Π΅ΠΊΡΠΎΡΠ°Π»ΡΠ½ΡΡ
ΡΠ΅ΠΎΡΠΈΠΉ. Π ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ, Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΡΠ΄Π΅Π»Π΅Π½ΠΎ ΠΌΠ΅ΡΠ°ΡΠΎΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΌΠΎΠ΄Π΅Π»ΡΠΌ, ΠΏΠΎΠ»ΠΈΡΠΈΠΊΠΎ-ΠΊΠΎΠΌΠΌΡΠ½ΠΈΠΊΠ°ΡΠΈΠ²Π½ΠΎΠΉ ΡΠ΅ΠΎΡΠΈΠΈ, ΡΠ΅ΠΎΡΠΈΠΈ ΠΌΠΎΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΡΡΠ»Π΅Π½ΠΈΡ, ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΒΡΠΊΠΈΠΌ (ΠΌΠ°ΡΠΊΠ΅ΡΠΈΠ½Π³ΠΎΠ²ΡΠΌ) ΡΠ΅ΠΎΡΠΈΡΠΌ ΠΈ Π΄Ρ.The article analyzes the basic communicative, manipulative political motivation factors that have determined the formation of the electoral theories. In particular, attention is given to metaphorical models, political and communication theory, the theory of reasoned political thought, technological (marketing) theories, etc
A case-only approach for assessing gene-sex interaction in human longevity
As one aspect of the complex feature of longevity, gene-sex interaction plays an important role in influencing human life span. With advances in molecular genetics, more studies aimed at assessing gene-sex interaction are expected. New and valid statistical methods are needed. In this paper, we introduce a nontraditional approach, the case-only design, which was originally proposed for assessing gene and disease associations, to detect gene-sex interaction in human longevity. Applications of this method to data collected from centenarian studies show that it can produce consistent results as compared with results obtained from case-control and other approaches. Important features of the application in human longevity studies are highlighted and discussed. Since centenarians constitute a special population representing successful ageing, the easily applicable case-only approach will be an important tool for screening potential major genes that contribute to human longevity. (AUTHORS)
Autoimmune diseases and new-onset atrial fibrillation:a UK Biobank study
AimsThe underlying mechanisms of atrial fibrillation (AF) are largely unknown. Inflammation may underlie atrial remodelling. Autoimmune diseases, related to increased systemic inflammation, may therefore be associated with new-onset AF.Methods and resultsParticipants from the population-based UK Biobank were screened for rheumatic fever, gastrointestinal autoimmune diseases, autoimmune diseases targeting the musculoskeletal system and connective tissues, and neurological autoimmune diseases. Between 2006 and 2022, participants were followed for incident AF. Cox proportional hazards regression analyses were performed to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) to quantify associations. 494 072 participants free from AF were included (median age 58.0 years, 54.8% women). After a median of 12.8 years, 27 194 (5.5%) participants were diagnosed with new-onset AF. Rheumatic fever without heart involvement (HR, 95% CI: 1.47, 1.26β1.72), Crohnβs disease (1.23, 1.05β1.45), ulcerative colitis (1.17, 1.06β1.31), rheumatoid arthritis (1.39, 1.28β1.51), polyarteritis nodosa (1.82, 1.04β3.09), systemic lupus erythematosus (1.82, 1.41β2.35), and systemic sclerosis (2.32, 1.57β3.44) were associated with a larger AF risk. In sex-stratified analyses, rheumatic fever without heart involvement, multiple sclerosis, Crohnβs disease, seropositive rheumatoid arthritis, psoriatic and enteropathic arthropathies, systemic sclerosis and ankylosing spondylitis were associated with larger AF risk in women, whereas only men showed a larger AF risk associated with ulcerative colitis.ConclusionsVarious autoimmune diseases are associated with new-onset AF, more distinct in women. Our findings elaborate on the pathophysiological differences in autoimmunity and AF risk between men and women
Individualized AngiotensinβConverting Enzyme (ACE)βInhibitor Therapy in Stable Coronary Artery Disease Based on Clinical and Pharmacogenetic Determinants: The PERindopril GENEtic (PERGENE) Risk Model
Patients with stable coronary artery disease (CAD) constitute a heterogeneous group in which the treatment benefits by angiotensin-converting enzyme (ACE)-inhibitor therapy vary between individuals. Our objective was to integrate clinical and pharmacogenetic determinants in an ultimate combined risk prediction model.Clinical, genetic, and outcomes data were used from 8726 stable CAD patients participating in the EUROPA/PERGENE trial of perindopril versus placebo. Multivariable analysis of phenotype data resulted in a clinical risk score (range, 0-21 points). Three single-nucleotide polymorphisms (rs275651 and rs5182 in the angiotensin-II type I-receptor gene and rs12050217 in the bradykinin type I-receptor gene) were used to construct a pharmacogenetic risk score (PGXscore; range, 0-6 points). Seven hundred eighty-five patients (9.0%) experienced the primary endpoint of cardiovascular mortality, nonfatal myocardial infarction or resuscitated cardiac arrest, during 4.2Β years of follow-up. Absolute risk reductions ranged from 1.2% to 7.5% in the 73.5% of patients with PGXscore of 0 to 2. As a consequence, estimated annual numbers needed to treat ranged from as low as 29 (clinical risk score β₯10 and PGXscore of 0) to 521 (clinical risk score β€6 and PGXscore of 2). Furthermore, our data suggest that long-term perindopril prescription in patients with a PGXscore of 0 to 2 is cost-effective.Both baseline clinical phenotype, as well as genotype determine the efficacy of widely prescribed ACE inhibition in stable CAD. Integration of clinical and pharmacogenetic determinants in a combined risk prediction model demonstrated a very wide range of gradients of absolute treatment benefit
Supplementation with orange and blackcurrant juice, but not vitamin E, improves inflammatory markers in patients with peripheral arterial disease
Optimizing psychotherapy dosage for comorbid depression and personality disorders (PsyDos): aΒ pragmatic randomized factorial trial using schema therapy and short-term psychodynamic psychotherapy
RNA-seq and Tn-seq reveal fitness determinants of vancomycin-resistant Enterococcus faecium during growth in human serum
BACKGROUND: The Gram-positive bacterium Enterococcus faecium is a commensal of the human gastrointestinal tract and a frequent cause of bloodstream infections in hospitalized patients. The mechanisms by which E. faecium can survive and grow in blood during an infection have not yet been characterized. Here, we identify genes that contribute to growth of E. faecium in human serum through transcriptome profiling (RNA-seq) and a high-throughput transposon mutant library sequencing approach (Tn-seq). RESULTS: We first sequenced the genome of E. faecium E745, a vancomycin-resistant clinical isolate, using a combination of short- and long read sequencing, revealing a 2,765,010Β nt chromosome and 6 plasmids, with sizes ranging between 9.3 kbp and 223.7 kbp. We then compared the transcriptome of E. faecium E745 during exponential growth in rich medium and in human serum by RNA-seq. This analysis revealed that 27.8% of genes on the E. faecium E745 genome were differentially expressed in these two conditions. A gene cluster with a role in purine biosynthesis was among the most upregulated genes in E. faecium E745 upon growth in serum. The E. faecium E745 transposon mutant library was then used to identify genes that were specifically required for growth of E. faecium in serum. Genes involved in de novo nucleotide biosynthesis (including pyrK_2, pyrF, purD, purH) and a gene encoding a phosphotransferase system subunit (manY_2) were thus identified to be contributing to E. faecium growth in human serum. Transposon mutants in pyrK_2, pyrF, purD, purH and manY_2 were isolated from the library and their impaired growth in human serum was confirmed. In addition, the pyrK_2 and manY_2 mutants were tested for their virulence in an intravenous zebrafish infection model and exhibited significantly attenuated virulence compared to E. faecium E745. CONCLUSIONS: Genes involved in carbohydrate metabolism and nucleotide biosynthesis of E. faecium are essential for growth in human serum and contribute to the pathogenesis of this organism. These genes may serve as targets for the development of novel anti-infectives for the treatment of E. faecium bloodstream infections
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