Does 4D transperineal ultrasound have additional value over 2D transperineal ultrasound for diagnosing posterior pelvic floor disorders in women with obstructed defecation syndrome?

Objective To establish the diagnostic test accuracy of two‐dimensional (2D) and four‐dimensional (4D) transperineal ultrasound (TPUS) for diagnosis of posterior pelvic floor disorders in women with obstructed defecation syndrome (ODS), in order to assess if 4D ultrasound imaging provides additional value. Methods This was a prospective cohort study of 121 consecutive women with ODS. Symptoms of ODS and pelvic organ prolapse on clinical examination were assessed using validated methods. All women underwent both 2D‐ and 4D‐TPUS. Imaging analysis was performed by two blinded observers. Posterior pelvic floor disorders were dichotomized into presence or absence, according to predefined cut‐off values. In the absence of a reference standard, a composite reference standard was created from a combination of results of evacuation proctography, magnetic resonance imaging and endovaginal ultrasound. Primary outcome measures were diagnostic test characteristics of 2D‐ and 4D‐TPUS for rectocele, enterocele, intussusception and anismus. Secondary outcome measures were interobserver agreement, agreement between the two imaging techniques, and association of severity of ODS symptoms and degree of posterior vaginal wall prolapse with conditions observed on imaging. Results For diagnosis of all four posterior pelvic floor disorders, there was no difference in sensitivity or specificity between 2D‐ and 4D‐TPUS (P = 0.131–1.000). Good agreement between 2D‐ and 4D‐TPUS was found for diagnosis of rectocele (κ = 0.675) and moderate agreement for diagnoses of enterocele, intussusception and anismus (κ = 0.465–0.545). There was no difference in rectocele depth measurements between the techniques (19.9 mm for 2D vs 19.0 mm for 4D, P = 0.802). Interobserver agreement was comparable for both techniques, although 2D‐TPUS had excellent interobserver agreement for diagnosis of enterocele and rectocele depth measurements, while this was only moderate and good, respectively, for 4D‐TPUS. Diagnoses of rectocele and enterocele on both 2D‐ and 4D‐TPUS were significantly associated with degree of posterior vaginal wall prolapse on clinical examination (odds ratio (OR) = 1.89–2.72). The conditions observed using either imaging technique were not associated with severity of ODS symptoms (OR = 0.82–1.13). Conclusions There is no evidence of superiority of 4D ultrasound acquisition to dynamic 2D ultrasound acquisition for the diagnosis of posterior pelvic floor disorders. 2D‐ and 4D‐TPUS could be used interchangeably to screen women with symptoms of ODS

Colleterial glands of Sesamia nonagrioides as a source of the host-recognition kairomone for the egg parasitoid Telenomus busseolae

The maize stemborer Sesamia nonagrioides glues its egg masses under the leaf sheaths or ear bracts using colleterial gland secretion. In spite of such concealed oviposition sites, these eggs are parasitized by Telenomus busseolae. The colleterial glands of S. nonagrioides are investigated as a possible source of the host-recognition kairomone for T. busseolae. This secretion, applied on glass beads, elicits intense antennal drumming and oviposition probing behaviour in the parasitoid. Through an histochemical study, neutral and acid glycoconjugates are identified as components of the secretion. Finally, using ultrastructural techniques, the colleterial glands are described and classified as comprising class 3 secretory cells

The Role of Fermions in Bubble Nucleation

We present a study of the role of fermions in the decay of metastable states of a scalar field via bubble nucleation. We analyze both one and three-dimensional systems by using a gradient expansion for the calculation of the fermionic determinant. The results of the one-dimensional case are compared to the exact results of previous work.Comment: 15 pages, revtex, 9 figure

Machine learning dihydrogen activation in the chemical space surrounding Vaska’s complex

Homogeneous catalysis using transition metal complexes is ubiquitously used for organic synthesis, as well as technologically relevant in applications such as water splitting and CO2 reduction. The key steps underlying homogeneous catalysis require a specific combination of electronic and steric effects from the ligands bound to the metal center. Finding the optimal combination of ligands is a challenging task due to the exceedingly large number of possibilities and the non-trivial ligand–ligand interactions. The classic example of Vaska\u27s complex, trans-[Ir(PPh3)2(CO)(Cl)], illustrates this scenario. The ligands of this species activate iridium for the oxidative addition of hydrogen, yielding the dihydride cis-[Ir(H)2(PPh3)2(CO)(Cl)] complex. Despite the simplicity of this system, thousands of derivatives can be formulated for the activation of H2, with a limited number of ligands belonging to the same general categories found in the original complex. In this work, we show how DFT and machine learning (ML) methods can be combined to enable the prediction of reactivity within large chemical spaces containing thousands of complexes. In a space of 2574 species derived from Vaska\u27s complex, data from DFT calculations are used to train and test ML models that predict the H2-activation barrier. In contrast to experiments and calculations requiring several days to be completed, the ML models were trained and used on a laptop on a time-scale of minutes. As a first approach, we combined Bayesian-optimized artificial neural networks (ANN) with features derived from autocorrelation and deltametric functions. The resulting ANNs achieved high accuracies, with mean absolute errors (MAE) between 1 and 2 kcal mol−1, depending on the size of the training set. By using a Gaussian process (GP) model trained with a set of selected features, including fingerprints, accuracy was further enhanced. Remarkably, this GP model minimized the MAE below 1 kcal mol−1, by using only 20% or less of the data available for training. The gradient boosting (GB) method was also used to assess the relevance of the features, which was used for both feature selection and model interpretation purposes. Features accounting for chemical composition, atom size and electronegativity were found to be the most determinant in the predictions. Further, the ligand fragments with the strongest influence on the H2-activation barrier were identified

Tunable violet radiation in a quasi-phase-matched periodically poled stoichiometric lithium tantalate waveguide by direct femtosecond laser writing

[EN]We report on violet-light generation using the femtosecond-laser written waveguides in periodically poled MgO:LiTaO3 crystal under conditions of third-order quasi-phase matching. Ten parallel depressed cladding waveguides are successfully fabricated with different grating periods in the same sample with fan-out χ(2) grating structures. These waveguides exhibit high optical quality with minimum insertion loss as low as 0.71 dB. Temperature and wavelength tuned second harmonic generation for different waveguides are demonstrated by using a tunable CW Ti sappire laser. Tunable violet second harmonic light has been generated with a single period over the range of 396 nm to 401 nm by varying the crystal temperature from 60 °C to 200 °C. At the quasi-phase matching temperature, 0.37 mW of violet light power at 397.2 nm is generated for a fundamental power of 336.7 mW, corresponding to a normalized conversion efficiency of 0.39%/(W·cm2). Our work contributes to designing tunable and efficient on-chip violet light sources based on femtosecond-laser written waveguides.This work was supported by the National Natural Science Foundation of China (Nos. 11874239 and 61775120); Major Program of Shandong Province Natural Science Foundation (Grant No. ZR2018ZB0649); National Key Research and Development Project (No. SQ2019YFA070063-01); MINECO (FIS2017-87970-R); and Ministerio de Economía y Competitividad de España (MAT2016-75362-C3-1-R)

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

<p>Abstract</p> <p>Background</p> <p>Overproduction of proinflammatory cytokines from activated microglia has been implicated as an important contributor to pathophysiology progression in both acute and chronic neurodegenerative diseases. Therefore, it is critical to elucidate intracellular signaling pathways that are significant contributors to cytokine overproduction in microglia exposed to specific stressors, especially pathways amenable to drug interventions. The serine/threonine protein kinase p38α MAPK is a key enzyme in the parallel and convergent intracellular signaling pathways involved in stressor-induced production of IL-1β and TNFα in peripheral tissues, and is a drug development target for peripheral inflammatory diseases. However, much less is known about the quantitative importance of microglial p38α MAPK in stressor-induced cytokine overproduction, or the potential of microglial p38α MAPK to be a druggable target for CNS disorders. Therefore, we examined the contribution of microglial p38αMAPK to cytokine up-regulation, with a focus on the potential to suppress the cytokine increase by inhibition of the kinase with pharmacological or genetic approaches.</p> <p>Methods</p> <p>The microglial cytokine response to TLR ligands 2/3/4/7/8/9 or to Aβ_1-42was tested in the presence of a CNS-penetrant p38α MAPK inhibitor, MW01-2-069A-SRM. Primary microglia from mice genetically deficient in p38α MAPK were used to further establish a linkage between microglia p38α MAPK and cytokine overproduction. The <it>in vivo </it>significance was determined by p38α MAPK inhibitor treatment in a LPS-induced model of acute neuroinflammation.</p> <p>Results</p> <p>Increased IL-1β and TNFα production by the BV-2 microglial cell line and by primary microglia cultures was inhibited in a concentration-dependent manner by the p38α MAPK-targeted inhibitor. Cellular target engagement was demonstrated by the accompanying decrease in the phosphorylation state of two p38α MAPK protein substrates, MK2 and MSK1. Consistent with the pharmacological findings, microglia from p38α-deficient mice showed a diminished cytokine response to LPS. Further, oral administration of the inhibitor blocked the increase of IL-1β in the cerebral cortex of mice stressed by intraperitoneal injection of LPS.</p> <p>Conclusion</p> <p>The p38α MAPK pathway is an important contributor to the increased microglial production of proinflammatory cytokines induced by diverse stressors. The results also indicate the feasibility of targeting p38α MAPK to modulate CNS proinflammatory cytokine overproduction.</p

Le Chatelier-Braun principle in cosmological physics

Assuming that dark energy may be treated as a fluid with a well defined temperature, close to equilibrium, we argue that if nowadays there is a transfer of energy between dark energy and dark matter, it must be such that the latter gains energy from the former and not the other way around.Comment: 6 pages, revtex file, no figures; version accepted for publication in General Relativity and Gravitatio

Dissipative perturbations for the K(n,n) Rosenau-Hyman equation

Compactons are compactly supported solitary waves for nondissipative evolution equations with nonlinear dispersion. In applications, these model equations are accompanied by dissipative terms which can be treated as small perturbations. We apply the method of adiabatic perturbations to compactons governed by the K(n,n) Rosenau-Hyman equation in the presence of dissipative terms preserving the "mass" of the compactons. The evolution equations for both the velocity and the amplitude of the compactons are determined for some linear and nonlinear dissipative terms: second-, fourth-, and sixth-order in the former case, and second- and fourth-order in the latter one. The numerical validation of the method is presented for a fourth-order, linear, dissipative perturbation which corresponds to a singular perturbation term

Noncyclic geometric phase for neutrino oscillation

We provide explicit formulae for the noncyclic geometric phases or Pancharatnam phases of neutrino oscillations. Since Pancharatnam phase is a generalization of the Berry phase, our results generalize the previous findings for Berry phase in a recent paper [Phys. Lett. B, 466 (1999) 262]. Unlike the Berry phase, the noncyclic geometric phase offers distinctive advantage in terms of measurement and prediction. In particular, for three-flavor mixing, our explicit formula offers an alternative means of determining the CP-violating phase. Our results can also be extended easily to explore geometric phase associated with neutron-antineutron oscillations

Modification to the power spectrum in the brane world inflation driven by the bulk inflaton

We compute the cosmological perturbations generated in the brane world inflation driven by the bulk inflaton. Different from the model that the inflation is a brane effect, we exhibit the modification of the power spectrum of scalar perturbations due to the existence of the fifth dimension. With the change of the initial vacuum, we investigate the dependence of the correction of the power spectrum on the choice of the vacuum.Comment: replaced with the revised version, accepted for publication in PR