Efficient Thermal Electric Skipping Strategy Applied to the Control of Series/Parallel Hybrid Powertrain

The optimal control of hybrid powertrains represents one of the most challenging tasks for the compliance with the legislation concerning CO2 and pollutant emission of vehicles. Most common off-line optimization strategies (Pontryagin minimum principle-PMP-or dynamic programming) allow to identify the optimal control along a predefined driving mission at the expense of a quite relevant computational effort. On-line strategies, suitable for on-vehicle implementation, involve a certain performance degradation depending on their degree of simplification and computational effort. In this work, a simplified control strategy is presented, where the conventional power-split logics, typical of the above-mentioned strategies, is here replaced with an alternative utilization of the thermal and electric units for the vehicle driving (Efficient Thermal Electric Skipping Strategy-ETESS). The choice between the units is realized at each time and is based on the comparison between the effective fuel rate of the thermal engine and an equivalent fuel rate related to the electrical power consumption. The equivalent fuel rate in a pure electric driving is associated to a combination of brake specific fuel consumption of the thermal engine, and electro-mechanical efficiencies along the driveline. The ETESS is applied for the simulation of segment C hybrid vehicle, equipped with a thermal engine and two electric units (motor and generator). The methodology is tested along regulatory driving cycles (WLTP, Artemis) and RDE, with different powertrain variants. Numerical results underline that the proposed approach performs very close to most common control strategies (consumed fuel per kilometer higher than PMP of about 1% on average). The main advantage is a reduced computational effort (decrease of 99% on average). The ETESS is straightforwardly adapted for an on-line implementation, through the introduction of an adaptative factor, preserving the computational effort and the fuel economy

Homozygous mutation in the prokineticin-receptor2 gene (Val274Asp) presenting as reversible Kallmann syndrome and persistent oligozoospermia: case report.

Prokineticin 2 (Prok2) or prokineticin-receptor2 (Prok-R2) gene mutations are associated with Kallmann syndrome (KS). We describe a new homozygous mutation of Prok-R2 gene in a man displaying KS with an apparent reversal of hypogonadism. The proband, offspring of consanguineous parents, presented at age 19 years with absent puberty, no sense of smell, low testosterone and gonadotrophin levels. Magnetic resonance imaging showed olfactory bulb absence. The patient achieved virilization and spermatogenesis with gonadotrophin administration. Two years after discontinuing hormonal therapy, he maintained moderate oligozoospermia and normal testosterone levels. Prok2 and Prok- R2 gene sequence analyses were performed. The proband had a homozygous mutation in Prok-R2 exon 2 that harbours the c.T820>A base substitution, causing the introduction of an aspartic acid in place of valine at position 274 (Val274Asp). His mother had the same mutation in heterozygous state. This report describes a novel homozygous mutation of Prok-R2 gene in a man with variant KS, underlying the role of Prok-R2 gene in the olfactory and reproductive system development in humans. Present findings indicate that markedly delayed activation of gonadotrophin secretion may occur in some KS cases with definite gene defects, and that oligozoospermia might result from a variant form of reversible hypogonadotrophic hypogonadism

Employment of an auto-regressive model for knock detection supported by 1D and 3D analyses

In this work, experimental data, carried out on a twin-cylinder turbocharged engine at full load operations and referred to a spark advance of borderline knock, are used to characterize the effects of cyclic dispersion on knock phenomena. 200 consecutive incylinder pressure signals are processed through a refined Auto-Regressive Moving Average (ARMA) mathematical technique, adopted to define the percentage of knocking cycles, through a prefixed threshold level. The heuristic method used for the threshold selection is then verified by 1D and 3D analyses. In particular, a 1D model, properly accounting for cycle-by-cycle variations, and coupled to a reduced kinetic sub-model, is used to reproduce the measured cycles, in terms of statistical distribution of a theoretical knock index. In addition, few individual cycles, representative of the whole dataset, are selected in a single operating condition in order to perform a more detailed knock analysis by means of a 3D CFD approach, coupled to a tabulated chemistry technique for auto-ignition modeling. Outcomes of 1D and 3D models are compared to the ARMA results and a substantial coherence of the numerical and experimental results is demonstrated. The integrated 1D and 3D analyses can hence help in supporting the choice of the experimental threshold level for knock identification, following a more standardized theoretical approach

1D numerical and experimental investigations of an ultralean pre-chamber engine

In recent years, lean-burn gasoline Spark-Ignition (SI) engines have been a major subject of investigations. With this solution, in fact, it is possible to simultaneously reduce NOx raw emissions and fuel consumption due to decreased heat losses, higher thermodynamic efficiency, and enhanced knock resistance. However, the real applicability of this technique is strongly limited by the increase in cyclic variation and the occurrence of misfire, which are typical for the combustion of homogeneous lean air/fuel mixtures. The employment of a Pre-Chamber (PC), in which the combustion begins before proceeding in the main combustion chamber, has already shown the capability of significantly extending the lean-burn limit. In this work, the potential of an ultralean PC SI engine for a decisive improvement of the thermal efficiency is presented by means of numerical and experimental analyses. The SI engine is experimentally investigated with and without the employment of the PC with the aim to analyze the real gain of this innovative combustion system. For both configurations, the engine is tested at various speeds, loads, and air-fuel ratios. A commercial gasoline fuel is directly injected into the Main Chamber (MC), while the PC is fed in a passive or active mode. Compressed Natural Gas (CNG) or Hydrogen (H2) is used in the actual case. A 1D model of the engine under study is implemented in a commercial modeling framework and is integrated with “in-house developed” sub-models for the simulation of the combustion and turbulence phenomena occurring in this unconventional engine. The numerical approach proves to reproduce the experimental data with good accuracy, without requiring any case-dependent tuning of the model constants. Both the numerical and experimental results show an improvement of the indicated thermal efficiency of the active PC, compared to the conventional ignition device, especially at high loads and low speeds. The injection of H2 into the PC leads to a significant benefit only with very lean mixtures. With the passive fueling of the PC, the lean-burn limit is less extended, with the consequent lower improvement potential for thermal efficiency

Neural substrates for processing task-irrelevant emotional distracters in maltreated adolescents with depressive disorders: A pilot study

In this pilot study, neural systems related to cognitive and emotional processing were examined using event-related functional magnetic resonance imaging in five maltreated youth with depressive disorders and eleven non-maltreated healthy participants. Subjects underwent an emotional oddball task, where they detected infrequent ovals (targets) within a continual stream of phase-scrambled images (standards). Sad and neutral images were intermittently presented as task-irrelevant distracters. The maltreated youth revealed significantly decreased activation in the left middle frontal gyrus and right precentral gyrus to target stimuli and significantly increased activation to sad stimuli in bilateral amygdala, left subgenual cingulate, left inferior frontal gyrus, and right middle temporal cortex compared to non-maltreated participants. Additionally, the maltreated youth showed significantly decreased activation to both attentional targets and sad distracters in the left posterior middle frontal gyrus compared to non-maltreated participants. In this exploratory study of dorsal control and ventral emotional circuits, we found that maltreated youth with distress disorders demonstrated dysfunction of neural systems related to cognitive control and emotional processing

Directed growth and fusion of membrane-wall microdomains requires CASP-mediated inhibition and displacement of secretory foci.

Casparian strips (CS) are aligned bands of lignin-impregnated cell walls, building an extracellular diffusion barrier in roots. Their structure profoundly differs from tight junctions (TJ), analogous structures in animals. Nonetheless, CS membrane domain (CSD) proteins 1-5 (CASP1-5) are homologues of occludins, TJ components. CASP-marked membranes display cell wall (matrix) adhesion and membrane protein exclusion. A full CASP knock-out now reveals CASPs are not needed for localized lignification, since correctly positioned lignin microdomains still form in the mutant. Ultra-structurally, however, these microdomains are disorganized, showing excessive cell wall growth, lack of exclusion zone and matrix adhesion, and impaired exocyst dynamics. Proximity-labelling identifies a Rab-GTPase subfamily, known exocyst activators, as potential CASP-interactors and demonstrate their localization and function at the CSD. We propose that CASP microdomains displace initial secretory foci by excluding vesicle tethering factors, thereby ensuring rapid fusion of microdomains into a membrane-cell wall band that seals the extracellular space

A novel human aquaporin-4 splice variant exhibits a dominant-negative activity: a new mechanism to regulate water permeability.

Two major isoforms of aquaporin-4 (AQP4) have been described in human tissue. Here we report the identification and functional analysis of an alternatively spliced transcript of human AQP4, AQP4-Δ4, that lacks exon 4. In transfected cells AQP4-Δ4 is mainly retained in the endoplasmic reticulum and shows no water transport properties. When AQP4-Δ4 is transfected into cells stably expressing functional AQP4, the surface expression of the full-length protein is reduced. Furthermore, the water transport activity of the cotransfectants is diminished in comparison to transfectants expressing only AQP4. The observed down-regulation of both the expression and water channel activity of AQP4 is likely to originate from a dominant-negative effect caused by heterodimerization between AQP4 and AQP4-Δ4, which was detected in coimmunoprecipitation studies. In skeletal muscles, AQP4-Δ4 mRNA expression inversely correlates with the level of AQP4 protein and is physiologically associated with different types of skeletal muscles. The expression of AQP4-Δ4 may represent a new regulatory mechanism through which the cell-surface expression and therefore the activity of AQP4 can be physiologically modulated

Seminal anti-Mullerian hormone level is a marker of spermatogenic response during long-term gonadotropin therapy in male hypogonadotropic hypogonadism

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Effects of the ionizing radiation disinfection treatment on historical leather

Microorganisms often cause significant damage on historical objects. The archive or library materials as well as textile or leather artifacts suffer serious attacks that need appropriate care treatments. Several biocide processes have been implemented but often their application does not preserve the material of the good. The objective of this work is the disinfection through ionizing radiation of leather wallpaper from the museum building Palazzo Chigi in Ariccia (Rome, Italy). The controlled sterilization treatments were carried out using X-ray beams to eliminate the microorganisms present on the leather and maintaining unchanged the properties of the constituent material. Some fragments of decorated leather wallpaper, dating back to the 1700s, were irradiated with X-rays up to 5,000 Gy. The amount of microorganisms was evaluated by microbiological analysis before and after X-ray irradiation treatments to identify the dose that inhibits the bacterial load. It will be shown how the results obtained by the application of different chemical-physical techniques (Scanning Electron Microscopy, Fourier Transform Infrared spectroscopy and Light Transmission Analysis) have helped in the evaluation of the impact of the X-rays on leather chemical and physical integrity

Intellectual, neurocognitive, and academic achievement in abstinent adolescents with cannabis use disorder

The active component of cannabis, delta-9 tetrahydrocannabinol (THC), has a long half-life and widespread neurocognitive effects. There are inconsistent reports of neurocognitive deficits in adults and adolescents with cannabis use disorders (CUD), particularly after a period of abstinence