32 research outputs found
Thyroid control over biomembranes: VI. Lipids in liver mitochondria and microsomes of hypothyroid rats
The lipids of liver mitochondria prepared from normal rats and from rats made hypothyroid by thyroidectomy and injection with131INa contained similar amounts, per mg protein, of total lipids, phospholipids, neutral lipids and lipid phosphorus. Hypothyroidism caused a doubling of the relative amounts of mitochondrial cardiolipins (CL; to 20.5% of the phospholipid P) and an accompanying trend (although statistically not significant) toward decreased amounts of both phosphatidylcholines (PC) and phosphatidylserines (PS), with phosphatidylethanolamines (PE) remaining unchanged. The pattern of elevated 18â¶2 fatty acyl content and depleted 20â¶4 acyl groups of the mitochondrial phospholipids of hypothyroid preparations was reflected to varying degrees in the resolved phospholipids, with PC showing greater degrees of abnormality than PE, and CL showing none. Hypothyroidism produced the same abnormal pattern of fatty acyl distributions in liver microsomal total lipids as was found in the mitochondria. Hypothyroid rats, when killed 6 hr after injection of [1â14C] labeled linoleate, showed the following abnormalities: the liver incorporated less label into lipids, and converted 18â¶2 not exclusively to 20â¶4 (as normals do) but instead incorporated the label mainly into saturated fatty acids. These data, together with the known decrease in ÎČâoxidation, suggest that hypothyroidism involves possible defective step(s) in the conversion of 18â¶2 to 20â¶4.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142296/1/lipd0328.pd
Temporal variation of rocky intertidal resident fish assemblages - patterns and possible mechanisms with a note on sampling protocols
CAF Activity, Calcium Concentration, Andy the 30,000-Dalton Component of Tough and Tender Bovine Longissimus Muscle
Recovery of ventilatory response to carbon dioxide after thiopentone, morphine and fentanyl in man
Mixed-effects analyses of rank-ordered data
latent trait models, latent class analysis, probabilistic choice models, nominal categories model, Luce's choice model,