Design of a high perveance convergent flow electron gun using computer trajectory simulation

This thesis presents a procedure for designing such an electron gun and illustrates its application with a practical example--an electron gun intended for use in an experimental high power traveling wave tube amplifier

Error tolerance and tradeoffs in loss- and failure-tolerant quantum computing schemes

Qubit loss and gate failure are significant problems for the development of scalable quantum computing. Recently, various schemes have been proposed for tolerating qubit loss and gate failure. These include schemes based on cluster and parity states. We show that by designing such schemes specifically to tolerate these error types we cause an exponential blowout in depolarizing noise. We discuss several examples and propose techniques for minimizing this problem. In general, this introduces a tradeoff with other undesirable effects. In some cases this is physical resource requirements, while in others it is noise rates

Delineating the activity of the potent nicotinic acetylcholine receptor agonists (+)-anatoxin-a and (−)-hosieine-A

The affinity and thermodynamic parameters for the interactions of two naturally occurring neurotoxins, (+)-anatoxin-a and (−)-hosieine-A, with acetylcholine-binding protein were investigated using a fluorescence-quenching assay and isothermal titration calorimetry. The crystal structures of their complexes with acetylcholine-binding protein from Aplysia californica (AcAChBP) were determined and reveal details of molecular recognition in the orthosteric binding site. Comparisons treating AcAChBP as a surrogate for human α4β2 and α7 nicotinic acetylcholine receptors (nAChRs) suggest that the molecular features involved in ligand recognition and affinity for the protein targets are conserved. The ligands exploit interactions with similar residues as the archetypal nAChR agonist nicotine, but with greater affinity. (−)-Hosieine-A in particular has a high affinity for AcAChBP driven by a favorable entropic contribution to binding. The ligand affinities help to rationalize the potent biological activity of these alkaloids. The structural data, together with comparisons with related molecules, suggest that there may be opportunities to extend the hosieine-A scaffold to incorporate new interactions with the complementary side of the orthosteric binding site. Such a strategy may guide the design of new entities to target human α4β2 nAChR that may have therapeutic benefit

Development of thermoregulation in Hawaiian brown noddies (Anous stolidus pileatus)

1. 1.|Oxygen consumption () and body temperture (Tb) of Hawaiian brown noddies (Anous stolidus pileatus [Aves: Laridae]) during late incubation and in the first 24 h after hatching were measured at ambient temperatures (Ta) between 28 and 38[deg]C and between 15 and 43[deg]C, respectively. Evaporative cooling by hatchings at Ta of 36-43[deg]C was also measured.2. 2.|Throughout the late incubation stages studied, and Tb both varied directly with Ta in an ectothermic pattern.3. 3.|The hatchlings successfully regulated Tb at Ta between ca. 29 and 43[deg]C.4. 4.|The functional basis of the abrupt increase in thermoregulatory capacity with hatching is discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/29056/1/0000089.pd

The return of the merging galaxy subclusters of El Gordo?

Merging galaxy clusters with radio relics provide rare insights to the merger dynamics as the relics are created by the violent merger process. We demonstrate one of the first uses of the properties of the radio relic to reduce the uncertainties of the dynamical variables and determine the 3D configuration of a cluster merger, ACT-CL J0102-4915, nicknamed El Gordo. From the double radio relic observation and the X-ray observation of a comet-like gas morphology induced by motion of the cool core, it is widely believed that El Gordo is observed shortly after the first core-passage of the subclusters. We employ a Monte Carlo simulation to investigate the three-dimensional (3D) configuration and dynamics of El Gordo. Using the polarization fraction of the radio relic, we constrain the estimate of the angle between the plane of the sky and the merger axis to be $\alpha = 21~{\rm degree} \pm^9_{11}$. We find the relative 3D merger speed of El Gordo to be $2400\pm^{400}_{200}~{\rm km}~{\rm s}^{-1}$ at pericenter. The two possible estimates of the time-since-pericenter are $0.46\pm^{0.09}_{0.16}$ Gyr and $0.91\pm^{0.22}_{0.39}$ Gyr for the outgoing and returning scenario respectively. We put our estimates of the time-since-pericenter into context by showing that if the time-averaged shock velocity is approximately equal to or smaller than the pericenter velocity of the corresponding subcluster in the center of mass frame, the two subclusters are more likely to be moving towards, rather than away, from each other, post apocenter. We compare and contrast the merger scenario of El Gordo with that of the Bullet Cluster, and show that this late-stage merging scenario explains why the southeast dark matter lensing peak of El Gordo is closer to the merger center than the southeast cool core.Comment: Figure 1 explains the configuration of the different components of El Gordo. Figure 9 explains the merger scenario. 20 pages, 23 figures. Accepted by MNRA

Spatially resolved capture of hydrogen sulfide from the water column and sedimentary pore waters for abundance and stable isotopic analysis

Sulfur cycling is ubiquitous in sedimentary environments, where it plays a major role in mediating carbon remineralization and impacts both local and global redox budgets. Microbial sulfur cycling is dominated by metabolic activity that either produces (e.g., sulfate reduction, disproportionation) or consumes (sulfide oxidation) hydrogen sulfide (H2S). As such, improved constraints on the production, distribution, and consumption of H2S in the natural environment will increase our understanding of microbial sulfur cycling. These different microbial sulfur metabolisms are additionally associated with particular stable isotopic fractionations. Coupling measurements of the isotopic composition of the sulfide with its distribution can provide additional information about environmental conditions and microbial ecology. Here we investigate the kinetics of sulfide capture on photographic films as a way to document the spatial distribution of sulfide in complex natural environments as well as for in situ capture of H2S for subsequent stable isotopic analysis. Laboratory experiments and timed field deployments demonstrate the ability to infer ambient sulfide abundances from the yield of sulfide on the films. This captured sulfide preserves the isotopic composition of the ambient sulfide, offset to slightly lower δ34S values by ~ 1.2 ± 0.5‰ associated with the diffusion of sulfide into the film and subsequent reaction with silver to form Ag2S precipitates. The resulting data enable the exploration of cm-scale lateral heterogeneity that complement most geochemical profiles using traditional techniques in natural environments. Because these films can easily be deployed over a large spatial area, they are also ideal for real-time assessment of the spatial and temporal dynamics of a site during initial reconnaissance and for integration over long timescales to capture ephemeral processes

Aquilegia, Vol. 17 No. 2, April-June 1993: Newsletter of the Colorado Native Plant Society

https://epublications.regis.edu/aquilegia/1067/thumbnail.jp