Decreased Vitamin B12 Levels in Children with Nocturnal Enuresis

Objectives. Nocturnal enuresis is a common pediatric problem, the etiology of which is unclear. In the present study, vitamin B12 and folate levels were measured in children with nocturnal enuresis and compared with those in healthy control group children to investigate whether there was any relation with enuresis and neurogenic maturation as a first time in the literature. Methods. In this cross-sectional study, we included thirty children (16 girls, 14 boys) who had presented with primary nocturnal enuresis (PNE) complaints in the study group and 31 children (13 girls, 18 boys) in the control group. Body weight and height measurements were obtained and complete blood counts and vitamin B12 and folate levels were measured in all children. Results. No difference was found in age, height, and weight between study and control groups. Also the mean levels of the hemoglobin, hematocrit, and mean corpuscular volume (MCV) were not different between the two groups. Significantly lower mean vitamin B12 and folate levels were found in the enuresis group compared with the control group. Conclusions. Further studies are needed to clarify B12 and folate deficiency in larger series so that these tests can be included in routine investigations of enuretic children

Association between blood group antigens and rheumatic valve involvement and severity ın endemic areas

AbstractBackgroundRheumatic valve disease is an important public health problem in developing countries. We sought to evaluate the possible role of blood antigens as a risk factor for severe rheumatic valve disease.MethodsTwo hundred and fifty-four patients with severe rheumatic mitral and/or aortic valve disease with the surgical indication were enrolled to the study. Control group was composed of age and gender matched 2668 healthy volunteers.ResultsThere were 216 patients with aortic valve involvement and 249 patients with mitral valve involvement. One hundred and seventy-five patients had mitral stenosis, 96 patients had severe mitral regurgitation and 61 patients had severe aortic regurgitation. The distribution of blood groups among patients was as follows: Group A=42.9%, Group B=19.2%, Group AB=8.6%, and Group O=29.1%. The distribution of blood groups in the control group was Group A=40.8%, Group B=16.4%, Group AB=7.6%, and Group O=35.1%. There was no significant difference between blood groups of patients and controls (p=0.141).ConclusionBlood group does not seem to be a risk factor for rheumatic valve involvement or severity of the disease