Anatomical localization of significant differences in DTI and TDI measurements between UCPPS patients (<i>N = 45</i>) and HCs (<i>N = 56</i>).

<p>A) Observed differences in mean diffusivity (MD). B) Observed differences in fractional anisotropy (FA). C) Observed differences in fiber track density. D) Observed differences in generalized anisotropy (GA). Significant clusters were determined by thresholding based on level of statistical significance (<i>P < 0</i>.<i>05</i>) and cluster-based corrections using random permutation analysis. Left column illustrates differences projected onto representative white matter fiber tracts.</p

Anatomical regions and corresponding cluster volumes showing significant differences in MD between UCPPS patients and HCs (HCs).

<p>Minimum cluster size = 171 uL from permutation analysis.</p

Anatomical regions and corresponding cluster volumes showing significant differences in fiber track density on TDI between UCPPS patients and HCs (HCs).

<p>Minimum cluster size = 111 uL from permutation analysis.</p

Correlation matrix between mean MD measurements and MAPP symptom scores in UCPPS patients, localized to ROIs identified as different between UCPPS and HCs on statistical parameter maps.

<p>Dendrograms on the left side of the correlation matrix show hierarchical clustering of ROIs based on the association between MD measurements and symptom scores. Images showing ROI localization are chosen for select associations. Up arrows within cells denote significantly positive correlations (<i>P<0</i>.<i>05</i>) and down arrows within cells denote significantly negative correlations (<i>P<0</i>.<i>05</i>). (Note the level of significance was not corrected for multiple comparisons in this exploratory analysis).</p

Correlation matrix between mean track density measurements and MAPP symptom scores in UCPPS patients, localized to ROIs identified as different between UCPPS and HCs on statistical parameter maps.

<p>Dendrograms on the left side of the correlation matrix show hierarchical clustering of ROIs based on the association between track density measurements and symptom scores. Images showing ROI localization are chosen for select associations. Up arrows within cells denote significantly positive correlations (<i>P<0</i>.<i>05</i>) and down arrows within cells denote significantly negative correlations (<i>P<0</i>.<i>05</i>). (Note the level of significance was not corrected for multiple comparisons in this exploratory analysis).</p

Sex differences in fiber track density within A) UCPPS patients, B) positive control patients with IBS, and C) healthy control (HC) participants.

<p>Significant clusters were determined by thresholding based on level of statistical significance (<i>P < 0</i>.<i>05</i>) and cluster-based corrections using random permutation analysis.</p

Anatomical localization of significant differences in DTI and TDI measurements between UCPPS patients (<i>N = 45</i>) and positive control patients with IBS (<i>N = 39</i>).

<p>A) Observed differences in mean diffusivity (MD). B) Observed differences in fractional anisotropy (FA). C) Observed differences in fiber track density. D) Observed differences in generalized anisotropy (GA). Significant clusters were determined by thresholding based on level of statistical significance (<i>P < 0</i>.<i>05</i>) and cluster-based corrections using random permutation analysis. Left column illustrates differences projected onto representative white matter fiber tracts.</p

Sex differences in fractional anisotropy (FA) within A) UCPPS patients, B) positive control patients with IBS, and C) healthy control (HC) participants.

<p>Significant clusters were determined by thresholding based on level of statistical significance (<i>P < 0</i>.<i>05</i>) and cluster-based corrections using random permutation analysis.</p

Sex differences in mean diffusivity (MD) within A) UCPPS patients, B) positive control patients with IBS, and C) healthy control (HC) participants.

<p>Significant clusters were determined by thresholding based on level of statistical significance (<i>P < 0</i>.<i>05</i>) and cluster-based corrections using random permutation analysis.</p

Anatomical regions and corresponding cluster volumes showing significant differences in FA between UCPPS patients and HCs (HCs).

<p>Minimum cluster size = 111 uL from permutation analysis.</p