Gavestinel does not improve outcome after acute intracerebral hemorrhage: an analysis from the GAIN International and GAIN Americas studies

<p><b>Background and Purpose:</b> Glycine Antagonist in Neuroprotection (GAIN) International and GAIN Americas trials were prospectively designed, randomized, placebo-controlled trials of gavestinel, a glycine-site antagonist and putative neuroprotectant drug administered within 6 hours of suspected ischemic or hemorrhagic stroke. Both trials reported that gavestinel was ineffective in ischemic stroke. This analysis reports the results in those with primary intracerebral hemorrhage.</p> <p><b>Methods:</b> The primary hypothesis was that gavestinel treatment did not alter outcome, measured at 3 months by the Barthel Index (BI), from acute intracerebral hemorrhage, based on pooled results from both trials. The BI scores were divided into 3 groups: 95 to 100 (independent), 60 to 90 (assisted independence), and 0 to 55 (dependent) or dead.</p> <p><b>Results:</b> In total, 3450 patients were randomized in GAIN International (N=1804) and GAIN Americas (N=1646). Of these, 571 were ultimately identified to have spontaneous intracerebral hematoma on baseline head computerized tomography scan. The difference in distribution of trichotomized BI scores at 3 months between gavestinel and placebo was not statistically significant (P=0.09). Serious adverse events were reported at similar rates in the 2 treatment groups.</p> <p><b>Conclusions:</b> These observations from the combined GAIN International and GAIN Americas trials suggest that gavestinel is not of substantial benefit or harm to patients with primary intracerebral hemorrhage. These findings are similar to results previously reported in patients with ischemic stroke.</p&gt

Operator-Algebraic Approach to the Yrast Spectrum of Weakly Interacting Trapped Bosons

We present an operator-algebraic approach to deriving the low-lying quasi-degenerate spectrum of weakly interacting trapped N bosons with total angular momentum \hbar L for the case of small L/N, demonstrating that the lowest-lying excitation spectrum is given by 27 g n_3(n_3-1)/34, where g is the strength of the repulsive contact interaction and n_3 the number of excited octupole quanta. Our method provides constraints for these quasi-degenerate many-body states and gives higher excitation energies that depend linearly on N.Comment: 7 pages, one figur

Characteristics and outcomes of culture-negative prosthetic joint infections from the Prosthetic Joint Infection in Australia and New Zealand Observational (PIANO) cohort study

Introduction: Culture-negative (CN) prosthetic joint infections (PJIs) account for approximately 10 % of all PJIs and present significant challenges for clinicians. We aimed to explore the significance of CN PJIs within a large prospective cohort study, comparing their characteristics and outcomes with culture-positive (CP) cases. Methods: The Prosthetic joint Infection in Australia and New Zealand Observational (PIANO) study is a prospective, multicentre observational cohort study that was conducted at 27 hospitals between 2014 and 2017. We compared baseline characteristics and outcomes of all patients with CN PJI from the PIANO cohort with those of CP cases. We report on PJI diagnostic criteria in the CN cohort and apply internationally recognized PJI diagnostic guidelines to determine optimal CN PJI detection methods. Results: Of the 650 patients with 24-month outcome data available, 55 (8.5 %) were CN and 595 were CP. Compared with the CP cohort, CN patients were more likely to be female (32 (58.2 %) vs. 245 (41.2 %); p = 0.016), involve the shoulder joint (5 (9.1 %) vs. 16 (2.7 %); p = 0.026), and have a lower mean C-reactive protein (142 mg L−1 vs. 187 mg L−1; p = 0.016). Overall, outcomes were superior in CN patients, with culture negativity an independent predictor of treatment success at 24 months (adjusted odds ratio, aOR, of 3.78 and 95 %CI of 1.65–8.67). Suboptimal diagnostic sampling was common in both cohorts, with CN PJI case detection enhanced using the Infectious Diseases Society of America PJI diagnostic guidelines. Conclusions: Current PJI diagnostic guidelines vary substantially in their ability to detect CN PJI, with comprehensive diagnostic sampling necessary to achieve diagnostic certainty. Definitive surgical management strategies should be determined by careful assessment of infection type, rather than by culture status alone

Microfluidic and Nanofluidic Cavities for Quantum Fluids Experiments

The union of quantum fluids research with nanoscience is rich with opportunities for new physics. The relevant length scales in quantum fluids, 3He in particular, are comparable to those possible using microfluidic and nanofluidic devices. In this article, we will briefly review how the physics of quantum fluids depends strongly on confinement on the microscale and nanoscale. Then we present devices fabricated specifically for quantum fluids research, with cavity sizes ranging from 30 nm to 11 microns deep, and the characterization of these devices for low temperature quantum fluids experiments.Comment: 12 pages, 3 figures, Accepted to Journal of Low Temperature Physic

Static and dynamic pressure effects on the thermolysis of nitroalkanes in solution

The authors have measured the effects of static and shock-induced pressures on the decomposition rates and mechanisms of various nitroalkanes dissolved in different solvents with and without organic amine catalysts. While nitroalkanes without {alpha}-hydrogen decompose by homolysis of the C-NO{sub 2} bond over a wide range of conditions, the decomposition pathway of nitroalkanes having {alpha}-hydrogens (i.e., acidic nitroalkanes) is complicated and follows different decomposition mechanisms depending on the availability of organic base and reaction pressure. The Nef reaction is also an important reaction pathway. The five known decomposition pathways, homolysis of the C-NO{sub 2} bond, bimolecular reaction between the aci-form and aci-ion, cyclization of the aci-form, elimination of nitrous acid, and the Nef reaction, are highly dependent on the reaction conditions, such as pressure, presence of organic amines, water, alcohols, and polarity of solvent. The authors discuss the results of several tests used to support these various decomposition mechanisms

The inverse moment problem for convex polytopes

The goal of this paper is to present a general and novel approach for the reconstruction of any convex d-dimensional polytope P, from knowledge of its moments. In particular, we show that the vertices of an N-vertex polytope in R^d can be reconstructed from the knowledge of O(DN) axial moments (w.r.t. to an unknown polynomial measure od degree D) in d+1 distinct generic directions. Our approach is based on the collection of moment formulas due to Brion, Lawrence, Khovanskii-Pukhikov, and Barvinok that arise in the discrete geometry of polytopes, and what variously known as Prony's method, or Vandermonde factorization of finite rank Hankel matrices.Comment: LaTeX2e, 24 pages including 1 appendi

Superfluid toroidal currents in atomic condensates

The dynamics of toroidal condensates in the presence of condensate flow and dipole perturbation have been investigated. The Bogoliubov spectrum of condensate is calculated for an oblate torus using a discrete-variable representation and a spectral method to high accuracy. The transition from spheroidal to toroidal geometry of the trap displaces the energy levels into narrow bands. The lowest-order acoustic modes are quantized with the dispersion relation $\omega \sim |m| \omega_s$ with $m=0,\pm 1,\pm 2, ...$. A condensate with toroidal current $\kappa$ splits the $|m|$ co-rotating and counter-rotating pair by the amount: $\Delta E \approx 2 |m|\hbar^2 \kappa < r^{-2}>$. Radial dipole excitations are the lowest energy dissipation modes. For highly occupied condensates the nonlinearity creates an asymmetric mix of dipole circulation and nonlinear shifts in the spectrum of excitations so that the center of mass circulates around the axis of symmetry of the trap. We outline an experimental method to study these excitations.Comment: 8 pages, 8 figure

Generation and evolution of vortex-antivortex pairs in Bose-Einstein condensates

We propose a method for generating and controlling a spatially separated vortex--antivortex pair in a Bose-Einstein condensate trapped in a toroidal potential. Our simulations of the time dependent Gross-Pitaevskii equation show that in toroidal condensates vortex dynamics are different from the dynamics in the homogeneous case. Our numerical results agree well with analytical calculations using the image method. Our proposal offers an effective example of coherent generation and control of vortex dynamics in atomic condensates.Comment: 4 pages, 2 figure

Attachment Styles Within the Coach-Athlete Dyad: Preliminary Investigation and Assessment Development

The present preliminary study aimed to develop and examine the psychometric properties of a new sport-specific self-report instrument designed to assess athletes’ and coaches’ attachment styles. The development and initial validation comprised three main phases. In Phase 1, a pool of items was generated based on pre-existing self-report attachment instruments, modified to reflect a coach and an athlete’s style of attachment. In Phase 2, the content validity of the items was assessed by a panel of experts. A final scale was developed and administered to 405 coaches and 298 athletes (N = 703 participants). In Phase 3, confirmatory factor analysis of the obtained data was conducted to determine the final items of the Coach-Athlete Attachment Scale (CAAS). Confirmatory factor analysis revealed acceptable goodness of fit indexes for a 3-first order factor model as well as a 2-first order factor model for both the athlete and the coach data, respectively. A secure attachment style positively predicted relationship satisfaction, while an insecure attachment style was a negative predictor of relationship satisfaction. The CAAS revealed initial psychometric properties of content, factorial, and predictive validity, as well as reliability

Vortex phase diagram in trapped Bose-Einstein condensation

The vortex phase diagram in the external rotation frequency versus temperature is calculated for dilute Bose-Einstein condensed gases. It is determined within the Bogoliubov-Popov theory for a finite temperature where the condensate and non-condensate fractions are treated in an equal footing. The temperature dependences of various thermodynamic instability lines for the vortex nucleation are computed to construct the phase diagram. Experiments are proposed to resolve a recent controversy on the vortex creation problem associated with the quantized vortex observation in $^{87}$Rb atom gases.Comment: 11 pages, 8 figure