Activity patterns of married women.

Thesis (Ed.M.)--Boston Universit

Premature babies born at the Boston City Hospital - A study of the development and the social factors affecting their progress as observed at the six months and one year levels, December 1946 and June 1947.

Thesis (M.S.)--Boston Universit

Engaging Youth in Local Government: Lessons from the Boston Region

There is widespread consensus that young people have a right to be directly involved in decisions that affect them, and an understanding that adults are the ones who must create formal pathways of engagement. Yet there remains limited empirical information about the best ways to do so. This paper identifies key lessons gleaned from a multi-method study of twenty-four operating municipal youth councils throughout the greater Boston region. The insight assembled here is based on interviews with youth and adult stakeholders, observations of council meetings, a review of council documents, as well as a review of relevant academic literature. It is intended to guide practitioners in developing or reforming local youth councils.Boston University Initiative on Citie

PRIMO: Practice-as-Research in Music Online

Slides for a presentation describing the JISC-funded PRIMO multimedia EPrints repository project, undertaken by the Institute of Musical Research (IMR) and ULCC. The project entailed extensive customisation of EPrints, to support streaming multimedia and complex submission workflows describing embedded intellectual property rights of performers and composers. The JISC RSP event "Open Access and Repositories in the Arts" was a one-day workshop that brought together librarians, research managers and information professionals from colleges of art, design, music, drama and communications, to explore issues surrounding open access to outputs in these fields

An audit of electron microscopy in the diagnosis of focal segmental glomerulosclerosis: are current pathological techniques missing important abnormalities in the glomerular basement membrane?

Background: There is an increasing appreciation that variants of the collagen IV genes may be associated with the development of focal segmental glomerulosclerosis (FSGS). On electron microscopy, such variants may produce characteristic changes within the glomerular basement membrane (GBM). These changes may be missed if glomerular lesions histologically diagnosed as FSGS on light microscopy are not subjected to electron microscopy. Methods: We conducted a retrospective cohort analysis of all patients presenting to two hospitals who received a primary histological diagnosis of FSGS to see if these samples underwent subsequent electron microscopy. Each such sample was also scrutinised for the presence of characteristic changes of an underlying collagen IV disorder. Results: A total of 43 patients were identified. Of these, only 30 underwent electron microscopy. In two samples there were histological changes detected that might have suggested the underlying presence of a collagen IV disorder. Around one in three biopsy samples that had a histological diagnosis of FSGS were not subjected to electron microscopy. Conclusion: Renal biopsy samples that have a histological diagnosis of primary FSGS not subjected to subsequent electron microscopy may potentially miss ultrastructural changes in the GBM that could signify an underlying collagen IV disorder as the patient’s underlying disease process. This could potentially affect both them and their families’ investigative and management decisions given potential for implications for transplant, heritability and different disease pathogenesis. This represents a gap in care which should be reflected upon and rectified via iterative standard care and unit-level quality assurance initiatives

Prenatal development is linked to bronchial reactivity: epidemiological and animal model evidence

Chronic cardiorespiratory disease is associated with low birthweight suggesting the importance of the developmental environment. Prenatal factors affecting fetal growth are believed important, but the underlying mechanisms are unknown. The influence of developmental programming on bronchial hyperreactivity is investigated in an animal model and evidence for comparable associations is sought in humans. Pregnant Wistar rats were fed either control or protein-restricted diets throughout pregnancy. Bronchoconstrictor responses were recorded from offspring bronchial segments. Morphometric analysis of paraffin-embedded lung sections was conducted. In a human mother-child cohort ultrasound measurements of fetal growth were related to bronchial hyperreactivity, measured at age six years using methacholine. Protein-restricted rats' offspring demonstrated greater bronchoconstriction than controls. Airway structure was not altered. Children with lesser abdominal circumference growth during 11-19 weeks' gestation had greater bronchial hyperreactivity than those with more rapid abdominal growth. Imbalanced maternal nutrition during pregnancy results in offspring bronchial hyperreactivity. Prenatal environmental influences might play a comparable role in humans