Project SEARCH: Analysis of Employment Outcomes for Students with Disabilities Across Two Districts

Rehabilitation professionals have a major focus on competitive employment, which is a central component of adult life that provides not only economic benefits, but also a social network and enhanced self-esteem. The employment gap for individuals with disabilities has remained consistently high despite concerted efforts to provide access to quality job readiness training and a simultaneous increase in awareness of the value of diversity in the workforce. This study examined the outcomes of Project SEARCH, an employer-based transition program for young adults with disabilities that promotes partnerships among the school and community by utilizing a unique collaborative approach that brings the education system, employers, and rehabilitation services together to provide meaningful individualized employment experiences for students with disabilities. Findings suggest Project SEARCH appears to have the potential to address employment outcomes for young adults with various disabilities. Implications for practice and future research are also discussed

Report on Interstate 476 (The Blue Route)

For fifty years Pennsylvanians have been discussing the idea of constructing a new north-south highway in the central part of Delaware County, the suburban county immediately west of the City of Philadelphia. Such a highway originally was conceived as a parkway. The notion never got very far until the mid-1950\u27s. When the federal Interstate Highway System was conceived, a facility in central Delaware County was proposed to connect the Pennsylvania Turnpike (I-276) in Plymouth Meeting, Montgomery County, with the Delaware Expressway (I-95) in Ridley Township, Delaware County. This facility was designated I-476. As conceived, it would constitute the western part of a planned circumferential freeway network around Philadelphia. I-476 is commonly known as the Blue Route and also as the Mid County Expressway. As an interstate highway project, 90% of the cost of I-476 would be covered by federal interstate highway funds allocated to the Pennsylvania Department of Transportation (PennDOT) by the Federal Highway Administration (FHWA). The remaining 10% of the project\u27s cost would be paid for by PennDOT (either construction bonds or revenues from the State Motor Fund). Construction of the Blue Route commenced in 1967 but all con­struction on the main stretch of the road--the 16.9 mile section be­ tween I-95 and the Schuylkill Expressway (I-76)--was halted in 1973. Construction of this portion cannot resume until the project undergoes an environmental impact assessment under the provisions of federal law. The project also must undergo a so-called 4(f) assessment analyzing the facility\u27s impact on parkland and historical resources. The requirements of these federal statutes are summarized in an appen­dix to this report. Because of the uncertainty surrounding completion of the Blue Route, and because the project has aroused considerable controversy in Delaware County, U.S. Representative Robert W. Edgar in March 1977 organized a Transportation Advisory Committee to un­dertake a comprehensive analysis of the project. [...] This report is submitted to the Congressman as the Committee\u27s recommendation

Is There Genetic Diversity in the ‘Leucaena Bug’ \u3cem\u3eSynergistes jonesii\u3c/em\u3e Which May Reflect Ability to Degrade Leucaena Toxins?

Leucaena leucocephala, a nutritionally rich forage tree legume, contains a non-protein amino acid, mimosine, which is degraded by ruminal bacteria to toxic metabolites 3,4-DHP and 2,3-DHP resulting in goitre-like symptoms in animals, severely restricting weight gain. Raymond Jones, in the early 1980s, discovered the ‘leucaena bug’ in the rumen of goats in Hawaii that degraded these toxic DHP metabolites into non-toxic compounds (Jones and Lowry 1984) which was named Synergistes jonesii (Allison et al. 1992) Subsequently, a rumen inoculum containing S. jonesii was used as an ‘oral drench’ for cattle, kept in continuous culture (Klieve et al. 2002) and supplied to farmers to dose cattle foraging on leucaena. Studies on Queensland herds that received this oral drench showed that up to 50% of 44 herds grazing on leucaena had apparent subclinical toxicity based on high 3,4- and 2,3-DHP excretion in urine (Dalzell et al., 2012). In another study by Graham et al. (2013), a 16S rDNA nested PCR showed that rumen digesta from 6 out of 8 properties tested had a variant DNA profile from S. jonesii ATCC 78.1 strain, which suggested a different strain of the bacterium. It was postulated that either the continually cultured oral inoculum may have undergone genetic modification and/or that animals could harbor other DHP degrading bacteria or S. jonesii strains with differential DHP degrading potential (McSweeney et al. unpublished). The present study looks at changes in the 16S rDNA gene at the molecular level that may suggest divergence from the type strain S. jonesii 78.1 (ATCC) in Queensland cattle as well as in cattle and other ruminants, internationally. These changes can appear as discrete mutations or ‘single nucleotide polymorphisms’ (SNPs) and may be correlated to their ability to degrade DHP, relative to the type strain

Sexual Signal Evolution Outpaces Ecological Divergence during Electric Fish Species Radiation

Natural selection arising from resource competition and environmental heterogeneity can drive adaptive radiation. Ecological opportunity facilitates this process, resulting in rapid divergence of ecological traits in many celebrated radiations. In other cases, sexual selection is thought to fuel divergence in mating signals ahead of ecological divergence. Comparing divergence rates between naturally and sexually selected traits can offer insights into processes underlying species radiations, but to date such comparisons have been largely qualitative. Here, we quantitatively compare divergence rates for four traits in African mormyrid fishes, which use an electrical communication system with few extrinsic constraints on divergence. We demonstrate rapid signal evolution in the Paramormyrops species flock compared to divergence in morphology, size, and trophic ecology. This disparity in the tempo of trait evolution suggests that sexual selection is an important early driver of species radiation in these mormyrids. We also found slight divergence in ecological traits among closely related species, consistent with a supporting role for natural selection in Paramormyrops diversification. Our results highlight the potential for sexual selection to drive explosive signal divergence when innovations in communication open new opportunities in signal space, suggesting that opportunity can catalyze species radiations through sexual selection, as well as natural selection

The establishment and utility of Sweha-Reg: a Swedish population-based registry to understand hereditary angioedema

<p>Abstract</p> <p>Background</p> <p>The importance of acquiring comprehensive epidemiological and clinical data on hereditary angioedema has increasingly caught the attention of physicians and scientists around the world. The development of networks and creation of comprehensive policies to improve care of people suffering from rare diseases, such as hereditary angioedema, is a stated top priority of the European Union.</p> <p>Hereditary angioedema is a rare disease, that it may be life-threatening. Although the exact prevalence is unknown, current estimates suggest that it is 1/10,000–1/150,000 individuals. The low prevalence requires combined efforts to gain accurate epidemiological data on the disease and so give us tools to reduce morbidity and mortality, and improve quality of life of sufferers.</p> <p>Methods</p> <p>Sweha-Reg is a population-based registry of hereditary angioedema in Sweden with the objectives of providing epidemiological data, and so creates a framework for the study of this disease. The registry contains individual-based data on diagnoses, treatments and outcomes.</p> <p>Conclusion</p> <p>The present manuscript seeks to raise awareness of the existence of Sweha-Reg to stimulate the international collaboration of registries. A synthesis of data from similar registries across several countries is required to approach an inclusive course understanding of HAE.</p

Occupational Risks during a Monkeypox Outbreak, Wisconsin, 2003

Veterinary staff were at high risk; standard veterinary infection-control guidelines should be followed

Lepton Flavour Violation in a Class of Lopsided SO(10) Models

A class of predictive SO(10) grand unified theories with highly asymmetric mass matrices, known as lopsided textures, has been developed to accommodate the observed mixing in the neutrino sector. The model class effectively determines the rate for charged lepton flavour violation, and in particular the branching ratio for $\mu -> e \gamma$, assuming that the supersymmetric GUT breaks directly to the constrained minimal supersymmetric standard model (CMSSM). We find that in light of the combined constraints on the CMSSM parameters from direct searches and from the WMAP satellite observations, the resulting predicted rate for $\mu -> e \gamma$ in this model class can be within the current experimental bounds for low $\tan \beta$, but that the next generation of $\mu -> e \gamma$ experiments would effectively rule out this model class if LFV is not detected.Comment: 23 page