The Planck Surveyor mission: astrophysical prospects

Although the Planck Surveyor mission is optimized to map the cosmic microwave background anisotropies, it will also provide extremely valuable information on astrophysical phenomena. We review our present understanding of Galactic and extragalactic foregrounds relevant to the mission and discuss on one side, Planck's impact on the study of their properties and, on the other side, to what extent foreground contamination may affect Planck's ability to accurately determine cosmological parameters. Planck's multifrequency surveys will be unique in their coverage of large areas of the sky (actually, of the full sky); this will extend by two or more orders of magnitude the flux density interval over which mm/sub-mm counts of extragalactic sources can be determined by instruments already available (like SCUBA) or planned for the next decade (like the LSA-MMA or the space mission FIRST), which go much deeper but over very limited areas. Planck will thus provide essential complementary information on the epoch-dependent luminosity functions. Bright radio sources will be studied over a poorly explored frequency range where spectral signatures, essential to understand the physical processes that are going on, show up. The Sunyaev-Zeldovich effect, with its extremely rich information content, will be observed in the direction of a large number of rich clusters of Galaxies. Thanks again to its all sky coverage, Planck will provide unique information on the structure and on the emission properties of the interstellar medium in the Galaxy. At the same time, the foregrounds are unlikely to substantially limit Planck's ability to measure the cosmological signals. Even measurements of polarization of the primordial Cosmic Microwave background fluctuations appear to be feasible.Comment: 20 pages, Latex (use aipproc2.sty, aipproc2.cls, epsfig.sty), 10 PostScript figures; invited review talk, Proc. of the Conference: "3 K Cosmology", Roma, Italy, 5-10 October 1998, AIP Conference Proc, in press Note: Figures 6 and 7 have been replaced by new and correct version

Developing an applied model for making decisions towards the end of life about care for someone with dementia

BACKGROUND: Many people with dementia reach the end-of-life without an advance care plan. Many are not ready to have conversations about end-of-life, and decision-making is left to their families and professionals when they no longer have capacity. Carers may benefit from further support with decision-making. To develop this support, it is important to understand the decision-making process. AIM: Explore with family carers and people living with dementia the decision-making process and factors that influence decision-making in dementia end of life care, to produce a model of decision-making in the context of dementia end-of-life care. METHODS: Semi-structured interviews with 21 family carers and 11 people with dementia in England (2018–2019) from memory clinics, general practice and carer organisations. Interviews were analysed using thematic analysis and findings were mapped onto the Interprofessional Shared Decision Making model, refined to produce a modified model of decision-making in dementia. RESULTS: Participants described five key decisions towards the end-of-life as examples of decision making. We used these experiences to produce a modified model of decision-making in dementia end-of-life-care. The model considers the contextual factors that influence the decision-making process, including: personal preferences; advance care planning and Lasting Power of Attorney; capacity and health and wellbeing of the person with dementia; support from others and clarity of roles. The decision-making process consists of seven inter-linked stages: 1) identifying the decision maker or team; 2) sharing and exchanging information; 3) clarifying values and preferences; 4) managing and considering emotions; 5) considering the feasibility of options; 6) balancing preferred choice and the actual choice; and 7) implementation and reflecting on outcomes. CONCLUSIONS: The modified model breaks down the decision-making process and attempts to simplify the process while capturing the subtle nuances of decision making. It provides a framework for conversations and supporting decisions by carers

Further Discoveries of 12CO in Low Surface Brightness Galaxies

Using the IRAM 30m telescope we have obtained seven new, deep CO J(1-0) and J(2-1) observations of low surface brightness (LSB) galaxies. Five of the galaxies have no CO detected to extremely low limits (0.1-0.4 K km/s at J(1-0)), while two of the galaxies, UGC 01922 and UGC 12289, have clear detections in both line transitions. When these observations are combined with all previous CO observations taken of LSB systems, we compile a total of 34 observations, in which only 3 galaxies have had detections of their molecular gas. Comparing the LSB galaxies with and without CO detections to a sample of high surface brightness (HSB) galaxies with CO observations indicates that it is primarily the low density of baryonic matter within LSB galaxies which is causing their low CO fluxes. Finally, we note that one of the massive LSB galaxies studied in this project, UGC 06968 (a Malin-1 `cousin'), has upper limits placed on both M_H2 and M_H2/M_HI which are 10-20 times lower than the lowest values found for any galaxy (LSB or HSB) with similar global properties. This may be due to an extremely low temperature and metallicity within UGC 06968, or simply due to the CO distribution within the galaxy being too diffuse to be detected by the IRAM beam.Comment: 18 pages, 8 figures, 4 tables. Accepted by Ap

The Energy-Momentum Tensor in Fulling-Rindler Vacuum

The energy density in Fulling-Rindler vacuum, which is known to be negative "everywhere" is shown to be positive and singular on the horizons in such a fashion as to guarantee the positivity of the total energy. The mechanism of compensation is displayed in detail.Comment: 9 pages, ULB-TH-15/9

Observations of the bright radio sources in the North Celestial Pole region at the RATAN-600 radio telescope

A survey of the North Celestial Pole region using the RATAN-600 radio telescope at five frequencies in the range 2.3 to 21.7 GHz is described. Sources were chosen from the NVSS catalogue. The flux densities of 171 sources in the Declination range +75 to +88 are presented; typical flux density errors are 5-10 percent including calibration errors. About 20 percent of the sources have flat spectra or a flat component.Comment: 21 pages, 7 figures; to be published in Astronomy and Astrophysics (without last figure with the spectra of the observed sources

Far-Ultraviolet Color Gradients in Early-Type Galaxies

We discuss far-UV (1500 A) surface photometry and FUV-B color profiles for 8 E/S0 galaxies from images taken with the Ultraviolet Imaging Telescope, primarily during the Astro-2 mission. In three cases, the FUV radial profiles are more consistent with an exponential than a de Vaucouleurs function, but there is no other evidence for the presence of a disk or of young, massive stars. In all cases except M32 the FUV-B color becomes redder at larger radii. There is a wide range of internal radial FUV-B color gradients. However, we find no correlation between the FUV-B color gradients and internal metallicity gradients based on Mg absorption features. We conclude that metallicity is not the sole parameter controlling the "UV upturn component" in old populations.Comment: 11 pages; tar.gz file includes LaTeX text file, 3 PostScript figures. Paper to be published in ApJ Letter

Computational and Biological Analogies for Understanding Fine-Tuned Parameters in Physics

In this philosophical paper, we explore computational and biological analogies to address the fine-tuning problem in cosmology. We first clarify what it means for physical constants or initial conditions to be fine-tuned. We review important distinctions such as the dimensionless and dimensional physical constants, and the classification of constants proposed by Levy-Leblond. Then we explore how two great analogies, computational and biological, can give new insights into our problem. This paper includes a preliminary study to examine the two analogies. Importantly, analogies are both useful and fundamental cognitive tools, but can also be misused or misinterpreted. The idea that our universe might be modelled as a computational entity is analysed, and we discuss the distinction between physical laws and initial conditions using algorithmic information theory. Smolin introduced the theory of "Cosmological Natural Selection" with a biological analogy in mind. We examine an extension of this analogy involving intelligent life. We discuss if and how this extension could be legitimated. Keywords: origin of the universe, fine-tuning, physical constants, initial conditions, computational universe, biological universe, role of intelligent life, cosmological natural selection, cosmological artificial selection, artificial cosmogenesis.Comment: 25 pages, Foundations of Science, in pres

Has the phasing out of stavudine in accordance with changes in WHO guidelines led to a decrease in single-drug substitutions in first-line antiretroviral therapy for HIV in sub-Saharan Africa?

This version is the Accepted Manuscript and is published in final edited form as: AIDS. 2017 January 02; 31(1): 147–157. doi:10.1097/QAD.0000000000001307OBJECTIVE: We assessed the relationship between phasing out stavudine in first-line antiretroviral therapy (ART) in accordance with WHO 2010 policy and single-drug substitutions (SDS) (substituting the nucleoside reverse transcriptase inhibitor in first-line ART) in sub-Saharan Africa. DESIGN: Prospective cohort analysis (International epidemiological Databases to Evaluate AIDS-Multiregional) including ART-naive, HIV-infected patients aged at least 16 years, initiating ART between January 2005 and December 2012. Before April 2010 (July 2007 in Zambia) national guidelines called for patients to initiate stavudine-based or zidovudine-based regimen, whereas thereafter tenofovir or zidovudine replaced stavudine in first-line ART. METHODS: We evaluated the frequency of stavudine use and SDS by calendar year 2004-2014. Competing risk regression was used to assess the association between nucleoside reverse transcriptase inhibitor use and SDS in the first 24 months on ART. RESULTS: In all, 33 441 (8.9%; 95% confience interval 8.7-8.9%) SDS occurred among 377 656 patients in the first 24 months on ART, close to 40% of which were amongst patients on stavudine. The decrease in SDS corresponded with the phasing out of stavudine. Competing risks regression models showed that patients on tenofovir were 20-95% less likely to require a SDS than patients on stavudine, whereas patients on zidovudine had a 75-85% decrease in the hazards of SDS when compared to stavudine. CONCLUSION: The decline in SDS in the first 24 months on treatment appears to be associated with phasing out stavudine for zidovudine or tenofovir in first-line ART in our study. Further efforts to decrease the cost of tenofovir and zidovudine for use in this setting is warranted to substitute all patients still receiving stavudine

Thermal and electrical conductivity of iron at Earth's core conditions

The Earth acts as a gigantic heat engine driven by decay of radiogenic isotopes and slow cooling, which gives rise to plate tectonics, volcanoes, and mountain building. Another key product is the geomagnetic field, generated in the liquid iron core by a dynamo running on heat released by cooling and freezing to grow the solid inner core, and on chemical convection due to light elements expelled from the liquid on freezing. The power supplied to the geodynamo, measured by the heat-flux across the core-mantle boundary (CMB), places constraints on Earth's evolution. Estimates of CMB heat-flux depend on properties of iron mixtures under the extreme pressure and temperature conditions in the core, most critically on the thermal and electrical conductivities. These quantities remain poorly known because of inherent difficulties in experimentation and theory. Here we use density functional theory to compute these conductivities in liquid iron mixtures at core conditions from first principles- the first directly computed values that do not rely on estimates based on extrapolations. The mixtures of Fe, O, S, and Si are taken from earlier work and fit the seismologically-determined core density and inner-core boundary density jump. We find both conductivities to be 2-3 times higher than estimates in current use. The changes are so large that core thermal histories and power requirements must be reassessed. New estimates of adiabatic heat-flux give 15-16 TW at the CMB, higher than present estimates of CMB heat-flux based on mantle convection; the top of the core must be thermally stratified and any convection in the upper core driven by chemical convection against the adverse thermal buoyancy or lateral variations in CMB heat flow. Power for the geodynamo is greatly restricted and future models of mantle evolution must incorporate a high CMB heat-flux and explain recent formation of the inner core.Comment: 11 pages including supplementary information, two figures. Scheduled to appear in Nature, April 201

A New Empirical Model for the Structural Analysis of Early-type Galaxies and a Critical Review of the Nuker Model

The Nuker law was designed to match the inner few (~3-10) arcseconds of predominantly nearby (< 30 Mpc) early-type galaxy light-profiles; it was never intended to describe an entire profile. The Sersic model, on the other hand, was developed to fit the entire profile; however, due to the presence of partially depleted galaxy cores, the Sersic model cannot always describe the very inner region. We have therefore developed a new empirical model consisting of an inner power-law, a transition region, and an outer Sersic model to connect the inner and outer structure of elliptical galaxies. Moreover, the stability of the Nuker model parameters are investigated. Surprisingly, none are found to be stable quantities; all are shown to vary systematically with a profile's fitted radial extent, and often by more than 100%. Considering elliptical galaxies spanning a range of 7.5 magnitudes, the central stellar density of the underlying host galaxy is observed to increase with galaxy luminosity until the onset of core formation, detected only in the brightest elliptical galaxies. We suggest that the so-called ``power-law'' galaxies may actually be described by the Sersic model over their entire radial range