Treatment Outcomes of Treatment-Naïve Hepatitis C Patients co-infected with HIV: a systematic review and meta-analysis of observational cohorts

Co-infection with Hepatitis C (HCV) and HIV is common and HIV accelerates hepatic disease progression due to HCV. However, access to HCV treatment is limited and success rates are generally poor

The Distance to the Coma Cluster from Surface Brightness Fluctuations

We report on the first determination of the distance to the Coma Cluster based on surface brightness fluctuation (SBF) measurements obtained from Hubble Space Telescope WFPC2 observations of the bright E0 galaxy NGC 4881 in the Coma Cluster and ground-based observations of the standard E1 galaxy NGC 3379 in the Leo-I group. Relative distances based on the I-band fluctuation magnitude, I(SBF), are strongly dependent on metallicity and age of the stellar population. However, the radial changes in the stellar populations of the two giant ellipticals, NGC 3379 and NGC 4881, are well described by published Mg_2 gradients, and the ground-based measurements of I(SBF) at several radial points in NGC 3379 are used to calibrate I(SBF) in terms of the Mg_2 index. The distance to NGC 3379, assumed to be identical to the average SBF distance of the Leo-I group, is combined with the new SBF measurements of NGC 4881 to obtain a Coma Cluster distance of 102+-14 Mpc. Combining this distance with the cosmic recession velocity of Coma (7186+-428 km/s), we find the Hubble constant to be H_0 = 71+-11 km/s/Mpc.Comment: 12 pages, LaTex, includes aaspp4.sty and 3 eps figures. To appear in ApJ Letter

Endometrial glands as a source of nutrients, growth factors and cytokines during the first trimester of human pregnancy: a morphological and immunohistochemical study.

BACKGROUND: The maternal circulation to the human placenta is not fully established until 10-12 weeks of pregnancy. During the first trimester the intervillous space is filled by a clear fluid, in part derived from secretions from the endometrial glands via openings in the basal plate. The aim was to determine the activity of the glands throughout the first trimester, and to identify components of the secretions. METHODS: Samples of human decidua basalis from 5-14 weeks gestational age were examined by transmission electron microscopy and immunohistochemically. An archival collection of placenta-in-situ samples was also reviewed. RESULTS: The thickness of the endometrium beneath the implantation site reduced from approximately 5 mm at 6 weeks to 1 mm at 14 weeks of gestation. The glandular epithelium also transformed from tall columnar cells, packed with secretory organelles, to a low cuboidal layer over this period. The lumens of the glands were always filled with precipitated secretions, and communications with the intervillous space could be traced until at least 10 weeks. The glandular epithelium reacted strongly for leukaemia inhibitory factor, vascular endothelial growth factor, epidermal growth factor, transforming growth factor beta, alpha tocopherol transfer protein, MUC-1 and glycodelin, and weakly for lactoferrin. As gestation advanced uterine natural killer cells became closely approximated to the basal surface of the epithelium. These cells were also immunopositive for epidermal growth factor. CONCLUSIONS: Morphologically the endometrial glands are best developed and most active during early human pregnancy. The glands gradually regress over the first trimester, but still communicate with the intervillous space until at least 10 weeks. Hence, they could provide an important source of nutrients, growth factors and cytokines for the feto-placental unit. The endometrium may therefore play a greater role in regulating placental growth and differentiation post-implantation than previously appreciated.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

Implications for the origin of dwarf early-type galaxies: a detailed look at the isolated rotating dwarf early-type galaxy CG 611, with ramifications for the Fundamental Plane's (S_K)^2 kinematic scaling and the spin-ellipticity diagram

Selected from a sample of nine, isolated, dwarf early-type galaxies (ETGs) having the same range of kinematic properties as dwarf ETGs in clusters, we use CG 611 (LEDA 2108986) to address the Nature versus Nurture debate regarding the formation of dwarf ETGs. The presence of faint disk structures and rotation within some cluster dwarf ETGs has often been heralded as evidence that they were once late-type spiral or dwarf irregular galaxies prior to experiencing a cluster-induced transformation into an ETG. However, CG 611 also contains significant stellar rotation (~20 km/s) over its inner half light radius, R_(e,maj)=0.71 kpc, and its stellar structure and kinematics resemble those of cluster ETGs. In addition to hosting a faint young nuclear spiral within a possible intermediate-scale stellar disk, CG 611 has accreted an intermediate-scale, counter-rotating gas disk. It is therefore apparent that dwarf ETGs can be built by accretion events, as opposed to disk-stripping scenarios. We go on to discuss how both dwarf and ordinary ETGs with intermediate-scale disks, whether under (de)construction or not, are not fully represented by the kinematic scaling S_0.5=sqrt{ 0.5(V_rot)^2 + sigma^2 }, and we also introduce a modified spin-ellipticity diagram, lambda(R)-epsilon(R), with the potential to track galaxies with such disks.Comment: 15 pages (includes 9 figures and an extensive 2+ page reference list

Total joint replacement in sub-Saharan Africa:a systematic review

Outcomes of arthroplasty in sub-Saharan Africa are not widely reported. To our knowledge, this systematic review is the first to explore this topic. Scopus, EMBASE, Medline and PubMed databases were searched, utilising MeSH headings and Boolean search strategies. All papers from South Africa were excluded. Twelve papers reporting 606 total hip replacements (THRs) and 763 total knee replacements (TKRs) were included. Avascular necrosis was the most common indication for THR, whereas osteoarthritis was the main indication for TKR. HIV prevalence of up to 33% was seen. Improvements were seen in patient-reported outcome measures in both THR and TKR. The dislocation rate in THR was 1.6%. The deep infection rate was 1.6% for TKRs and 0.5% for THRs. Positive results were reported, with comparable complications to high-income countries. However, there is likely to be significant reporting bias and the introduction of mandatory registries would enable more accurate monitoring across the region

Anti-microbial Use in Animals: How to Assess the Trade-offs

Antimicrobials are widely used in preventive and curative medicine in animals. Benefits from curative use are clear – it allows sick animals to be healthy with a gain in human welfare. The case for preventive use of antimicrobials is less clear cut with debates on the value of antimicrobials as growth promoters in the intensive livestock industries. The possible benefits from the use of antimicrobials need to be balanced against their cost and the increased risk of emergence of resistance due to their use in animals. The study examines the importance of animals in society and how the role and management of animals is changing including the use of antimicrobials. It proposes an economic framework to assess the trade-offs of anti-microbial use and examines the current level of data collection and analysis of these trade-offs. An exploratory review identifies a number of weaknesses. Rarely are we consistent in the frameworks applied to the economic assessment anti-microbial use in animals, which may well be due to gaps in data or the prejudices of the analysts. There is a need for more careful data collection that would allow information on (i) which species and production systems antimicrobials are used in, (ii) what active substance of antimicrobials and the application method and (iii) what dosage rates. The species need to include companion animals as well as the farmed animals as it is still not known how important direct versus indirect spread of resistance to humans is. In addition, research is needed on pricing antimicrobials used in animals to ensure that prices reflect production and marketing costs, the fixed costs of anti-microbial development and the externalities of resistance emergence. Overall, much work is needed to provide greater guidance to policy, and such work should be informed by rigorous data collection and analysis systems

A Morphological-type dependence in the mu_0-log(h) plane of Spiral galaxy disks

We present observational evidence for a galaxy `Type' dependence to the location of a spiral galaxy's disk parameters in the mu_0-log(h) (central disk surface-brightness - disk scale-length) plane. With a sample of ~40 Low Surface Brightness galaxies (both bulge- and disk-dominated) and ~80 High Surface Brightness galaxies, the early-type disk galaxies (<=Sc) tend to define a bright envelope in the mu_0-log(h) plane, while the late-type (>=Scd) spiral galaxies have, in general, smaller and fainter disks. Below the defining surface brightness threshold for a Low Surface Brightness galaxy (i.e. more than 1 mag fainter than the 21.65 B-mag arcsec^(-2) Freeman value), the early-type spiral galaxies have scale-lengths greater than 8-9 kpc, while the late-type spiral galaxies have smaller scale-lengths. All galaxies have been modelled with a seeing-convolved Sersic r^(1/n) bulge and exponential disk model. We show that the trend of decreasing bulge shape parameter (n) with increasing Hubble type and decreasing bulge-to-disk luminosity ratio, which has been observed amongst the High Surface Brightness galaxies, extends to the Low Surface Brightness galaxies, revealing a continuous range of structural parameters.Comment: To be published in ApJ. Inc. three two-part figure

Empirical Models for Dark Matter Halos. III. The Kormendy relation and the log(rho_e)-log(R_e) relation

We have recently shown that the 3-parameter density-profile model from Prugniel & Simien provides a better fit to simulated, galaxy- and cluster-sized, dark matter halos than an NFW-like model with arbitrary inner profile slope gamma (Paper I). By construction, the parameters of the Prugniel-Simien model equate to those of the Sersic R^{1/n} function fitted to the projected distribution. Using the Prugniel-Simien model, we are therefore able to show that the location of simulated (10^{12} M_sun) galaxy-sized dark matter halos in the _e-log(R_e) diagram coincides with that of brightest cluster galaxies, i.e., the dark matter halos appear consistent with the Kormendy relation defined by luminous elliptical galaxies. These objects are also seen to define the new, and equally strong, relation log(rho_e) = 0.5 - 2.5log(R_e), in which rho_e is the internal density at r=R_e. Simulated (10^{14.5} M_sun) cluster-sized dark matter halos and the gas component of real galaxy clusters follow the relation log(rho_e) = 2.5[1 - log(R_e)]. Given the shapes of the various density profiles, we are able to conclude that while dwarf elliptical galaxies and galaxy clusters can have dark matter halos with effective radii of comparable size to the effective radii of their baryonic component, luminous elliptical galaxies can not. For increasingly large elliptical galaxies, with increasingly large profile shapes `n', to be dark matter dominated at large radii requires dark matter halos with increasingly large effective radii compared to the effective radii of their stellar component.Comment: AJ, in press. (Paper I can be found at astro-ph/0509417