Headache

From a dissertation read before the Society on February 4th, 1966.Headache is a symptom which may be a feature of a wide range of conditions, arising not only with pathology in the head but also in cardio-vascular, renal, metabolic, orthopaedic and psychiatric conditions. It is extremely common, and usually transitory. Yet it may be a symptom of great significance in clinical practice. The underlying mechanisms are largely unknown. The explanations of the cause of headaches have a long history, and it is on the aetiology of headache that this discussion will centre.Headache can be a dramatic symptom and presumably has been ever since primitive man drank a fermented juice to excess and had his first hangover, or woke up with his first postconcussional headache to find that his wife had been kidnapped

Darcin: a male pheromone that stimulates female memory and sexual attraction to an individual male's odour

<p>Abstract</p> <p>Background</p> <p>Among invertebrates, specific pheromones elicit inherent (fixed) behavioural responses to coordinate social behaviours such as sexual recognition and attraction. By contrast, the much more complex social odours of mammals provide a broad range of information about the individual owner and stimulate individual-specific responses that are modulated by learning. How do mammals use such odours to coordinate important social interactions such as sexual attraction while allowing for individual-specific choice? We hypothesized that male mouse urine contains a specific pheromonal component that invokes inherent sexual attraction to the scent and which also stimulates female memory and conditions sexual attraction to the airborne odours of an individual scent owner associated with this pheromone.</p> <p>Results</p> <p>Using wild-stock house mice to ensure natural responses that generalize across individual genomes, we identify a single atypical male-specific major urinary protein (MUP) of mass 18893Da that invokes a female's inherent sexual attraction to male compared to female urinary scent. Attraction to this protein pheromone, which we named darcin, was as strong as the attraction to intact male urine. Importantly, contact with darcin also stimulated a strong learned attraction to the associated airborne urinary odour of an individual male, such that, subsequently, females were attracted to the airborne scent of that specific individual but not to that of other males.</p> <p>Conclusions</p> <p>This involatile protein is a mammalian male sex pheromone that stimulates a flexible response to individual-specific odours through associative learning and memory, allowing female sexual attraction to be inherent but selective towards particular males. This 'darcin effect' offers a new system to investigate the neural basis of individual-specific memories in the brain and give new insights into the regulation of behaviour in complex social mammals.</p> <p>See associated Commentary <url>http://www.biomedcentral.com/1741-7007/8/71</url></p

Res Medica, Spring 1966, Volume V, Number 2

TABLE OF CONTENTSNEUROLOGICAL EXAMINATION: J. B. Stanton F.R.C.P.E., F.R.C.P., D.P.M.THE FIELD OF ALLERGY: K. K. Adjepon-Yamoah, B.Sc.RES MEDICATHE SOCIETY  SEX CHROMOSOME ABNORMALITIES IN THE MALE: Patricia A. JacobsHEADACHE: Duncan L. Davidson, B.Sc.BOOK REVIEW

Long-Term Optical Monitoring of Eta Carinae. Multiband light curves for a complete orbital period

The periodicity of 5.5 years for some observational events occurring in Eta Carinae manifests itself across a large wavelength range and has been associated with its binary nature. These events are supposed to occur when the binary components are close to periastron. To detect the previous periastron passage of Eta Car in 2003, we started an intensive, ground-based, optical, photometric observing campaign. We continued observing the object to monitor its photometric behavior and variability across the entire orbital cycle. Our observation program consisted of daily differential photometry from CCD images, which were acquired using a 0.8 m telescope and a standard BVRI filter set at La Plata Observatory. The photometry includes the central object and the surrounding Homunculus nebula. We present up-to-date results of our observing program, including homogeneous photometric data collected between 2003 and 2008. Our observations demonstrated that Eta Car has continued increasing in brightness at a constant rate since 1998. In 2006, it reached its brightest magnitude (V ~ 4.7) since about 1860s. The object then suddenly reverted its brightening trend, fading to V = 5.0 at the beginning of 2007, and has maintained a quite steady state since then. We continue the photometric monitoring of Eta Car in anticipation of the next "periastron passage", predicted to occur at the beginning of 2009.Comment: Accepted by A&A. The paper contains 3 figures and 2 table

R parity violating contribution to e+e−(μ+μ−)→tcˉe^+e^-(\mu^+\mu^-)\to t{\bar c}

In this article we consider the contribution of $R_p$ violating couplings to the process $e^+e^-(\mu^+\mu^-)\to t{\bar c}$ at high energy lepton collider. We show that the present upper bound on the relevant $R_p$ violating coulpings obtained from low energy measurements would produce a few hundred to a thousand top-charm events at the next linear $e^+e^-(\mu^+\mu^-)$ collider. Hence, it should be possible to observe the rare process at future lepton collider.Comment: LaTEX, 13 pages, one figure is removed. A brief discussion on possible backgrounds is added. To appear in Phys. Rev.

Performance of A1C for the Classification and Prediction of Diabetes

OBJECTIVE Although A1C is now recommended to diagnose diabetes, its test performance for diagnosis and prognosis is uncertain. Our objective was to assess the test performance of A1C against single and repeat glucose measurements for diagnosis of prevalent diabetes and for prediction of incident diabetes. RESEARCH DESIGN AND METHODS We conducted population-based analyses of 12,485 participants in the Atherosclerosis Risk in Communities (ARIC) study and a subpopulation of 691 participants in the Third National Health and Nutrition Examination Survey (NHANES III) with repeat test results. RESULTS Against a single fasting glucose ≥126 mg/dl, the sensitivity and specificity of A1C ≥6.5% for detection of prevalent diabetes were 47 and 98%, respectively (area under the curve 0.892). Against repeated fasting glucose (3 years apart) ≥126 mg/dl, sensitivity improved to 67% and specificity remained high (97%) (AUC 0.936). Similar results were obtained in NHANES III against repeated fasting glucose 2 weeks apart. The accuracy of A1C was consistent across age, BMI, and race groups. For individuals with fasting glucose ≥126 mg/dl and A1C ≥6.5% at baseline, the 10-year risk of diagnosed diabetes was 88% compared with 55% among those individuals with fasting glucose ≥126 mg/dl and A1C 5.7–<6.5%. CONCLUSIONS A1C performs well as a diagnostic tool when diabetes definitions that most closely resemble those used in clinical practice are used as the “gold standard.” The high risk of diabetes among individuals with both elevated fasting glucose and A1C suggests a dual role for fasting glucose and A1C for prediction of diabetes. Although A1C is now recommended for the diagnosis of diabetes (1,2), its precise test performance is uncertain. The lack of a single, clear “gold standard” poses a challenge for determining the performance of A1C. Previous diagnostic studies of A1C have relied exclusively on a single elevated fasting or 2-h glucose values as gold standards (3–5). However, because glucose determinations are inherently more variable than A1C (6), these convenient gold standards are likely to reduce the apparent accuracy of A1C as a diagnostic test. A stronger gold standard would rely on repeated glucose determinations on different days (2), i.e., the recommended approach to diagnosis of diabetes in clinical practice. Alternatively, A1C and fasting glucose can be compared head-to-head against the subsequent development of clinically diagnosed diabetes as the gold standard. We hypothesized that 1) A1C would perform well as a diagnostic and prognostic test for diabetes across its full range and at the American Diabetes Association–recommended threshold of 6.5% and 2) that its performance would be best when judged against stronger, most clinically relevant gold standards

Millimeter-wave emission during the 2003 low excitation phase of eta Carinae

In this paper we present observations of eta Carinae in the 1.3 mm and 7 mm radio continuum, during the 2003.5 low excitation phase. The expected minimum in the light curves was confirmed at both wavelengths and was probably due to a decrease in the number of UV photons available to ionize the gas surrounding the binary system. At 7 mm a very well defined peak was superimposed on the declining flux density. It presented maximum amplitude in 29 June 2003 and lasted for about 10 days. We show that its origin can be free-free emission from the gas at the shock formed by wind-wind collision, which is also responsible for the observed X-ray emission. Even though the shock strength is strongly enhanced as the two stars in the binary system approach each other, during periastron passage the X-ray emission is strongly absorbed and the 7 mm observations represent the only direct evidence of this event

A multispectral view of the periodic events in eta Carinae

A full description of the 5.5-yr low excitation events in Eta Carinae is presented. We show that they are not as simple and brief as previously thought, but a combination of two components. The first, the 'slow variation' component, is revealed by slow changes in the ionization level of circumstellar matter across the whole cycle and is caused by gradual changes in the wind-wind collision shock-cone orientation, angular opening and gaseous content. The second, the 'collapse' component, is restricted to around the minimum, and is due to a temporary global collapse of the wind-wind collision shock. High energy photons (E > 16 eV) from the companion star are strongly shielded, leaving the Weigelt objects at low ionization state for >6 months. High energy phenomena are sensitive only to the 'collapse', low energy only to the 'slow variation' and intermediate energies to both components. Simple eclipses and mechanisms effective only near periastron (e.g., shell ejection or accretion onto the secondary star) cannot account for the whole 5.5-yr cycle. We find anti-correlated changes in the intensity and the radial velocity of P Cygni absorption profiles in FeII 6455 and HeI 7065 lines, indicating that the former is associated to the primary and the latter to the secondary star. We present a set of light curves representative of the whole spectrum, useful for monitoring the next event (2009 January 11).Comment: 16 pages, 7 EPS figures, accepted for publication on MNRA