From 'iron fists' to 'bunches of fives': A critical reflection on dialogue (or liaison) approaches to policing political protest

This article focuses on the recent academic assertion that police attempts to engage in dialogue before and during protest events (ostensibly to facilitate the participants’ preferred means of political expression) are perhaps more realistically concerned with collecting useful intelligence about demonstrators’ likely motives and activities, and preparing advance justification for possible police interventions. A case study is presented of the work carried out by a 15-person South Yorkshire Police ‘Police Liaison Team’ (PLT) in relation to the ‘anti-Lib Dem’ political protest occurring in the major English city of Sheffield in March 2011. Using a combination of participant observation and interviews with police and demonstrators, the study highlights compelling similarities between the tactical approach and underlying objectives of the PLT and those subscribed to by public order specialists in the Metropolitan Police Service in the early 1990s. In common with their ‘Met’ counterparts, the PLT used carefully cultivated exchange relationships with protest organisers as means of gathering intelligence, securing compliance with police preferences for the routes of marches and establishing parameters of ‘acceptable’ behaviour. However, by using the relatively new tactic of immersing themselves in the crowd, PLT members were also able to maintain ‘open’ lines of communication with protesters and provide a stream of unerringly accurate ‘dynamic risk assessments’ to remote senior commanders. This tactic helped to ensure that there were few unsettling ‘surprises’ on both sides, that there were no unnecessary, indiscriminate or over-punitive police interventions, and that the police operation was ultimately regarded by protest organisers as having been exceptionally tolerant and ‘facilitating’

Building on Treacherous Ground: Sense-of-Purpose Research and Demarcating Problematic Purposes

Developmental psychologist Damon’s (Damon, Menon, & Cotton Bronk, 2003) ongoing research program on youth purpose may have important practical implications for education. However, in the course of the development of this research, two fundamental conceptual questions have not yet been resolved satisfactorily: (a) How should “sense of purpose” be defined? and (b) How can one distinguish between noble and ignoble purposes? A careful examination of Damon et al.’s (2003) approach to these two questions is conducted, and some significant shortcomings in the analysis are pointed out. Specifically, Damon et al.’s definition of purpose is shown to be idiosyncratic, and some defects are pointed out in the criteria offered to differentiate between noble and ignoble purposes. In conclusion, an alternative approach to demarcating purpose is offered that relies on Erikson’s (1968) concept of totalized identity

Recovering a Forgotten Pioneer of Science Studies: C. E. Ayres’ Deweyan Critique of Science and Technology

This paper brings to light the ideas of a pioneering but largely forgotten social critic, C. E. Ayres. In his first book, Science: The False Messiah (1927), which was written in consultation with John Dewey, Ayres advanced a forceful and original critique of science and technology. He argued that technological change was occurring at a pace that had overwhelmed existing social institutions, and further claimed that efforts to solve the problem by educating citizens about science and technology would prove fruitless. The analysis presented in this paper outlines Ayres’ key arguments, examines the mutual influences between Dewey and Ayres, and makes a case that many of Ayres’ innovative arguments remain surprisingly relevant today

Diamonds On The Inside: Imaging Nanodiamonds With Hyperpolarized MRI

Nontoxic nanodiamonds (NDs) have proven useful as a vector for therapeutic drug delivery to cancers and as optical bioprobes of subcellular processes. Despite their potential clinical relevance, an effective means of noninvasively imaging NDs in vivo is still lacking. Recent developments in hyperpolarized MRI leverage an over 10 000 times increase in the nuclear polarization of biomolecules, enabling new molecular imaging applications. This work explores hyperpolarization via intrinsic paramagnetic defects in nanodiamond. We present the results of MRI experiments that enable direct imaging of nanodiamond via hyperpolarized 13C MRI and indirect imaging of nanodiamonds via Overhauser-enhanced MRI. The construction of custom hardware for these experiments is detailed and the path to future in vivo experiments outlined. As nanodiamond has been established as a biocompatible platform for drug delivery, our results will motivate further research into hyperpolarized MRI for tracking nanoparticles in vivo

LDLR-Gene therapy for familial hypercholesterolaemia: Problems, progress, and perspectives

Coronary artery diseases (CAD) inflict a heavy economical and social burden on most populations and contribute significantly to their morbidity and mortality rates. Low-density lipoprotein receptor (LDLR) associated familial hypercholesterolemia (FH) is the most frequent Mendelian disorder and is a major risk factor for the development of CAD. To date there is no cure for FH. The primary goal of clinical management is to control hypercholesterolaemia in order to decrease the risk of atherosclerosis and to prevent CAD. Permanent phenotypic correction with single administration of a gene therapeutic vector is a goal still needing to be achieved. The first ex vivo clinical trial of gene therapy in FH was conducted nearly 18 years ago. Patients who had inherited LDLR gene mutations were subjected to an aggressive surgical intervention involving partial hepatectomy to obtain the patient's own hepatocytes for ex vivo gene transfer with a replication deficient LDLR-retroviral vector. After successful re-infusion of transduced cells through a catheter placed in the inferior mesenteric vein at the time of liver resection, only low-level expression of the transferred LDLR gene was observed in the five patients enrolled in the trial. In contrast, full reversal of hypercholesterolaemia was later demonstrated in in vivo preclinical studies using LDLR-adenovirus mediated gene transfer. However, the high efficiency of cell division independent gene transfer by adenovirus vectors is limited by their short-term persistence due to episomal maintenance and the cytotoxicity of these highly immunogenic viruses. Novel long-term persisting vectors derived from adeno-associated viruses and lentiviruses, are now available and investigations are underway to determine their safety and efficiency in preparation for clinical application for a variety of diseases. Several novel non-viral based therapies have also been developed recently to lower LDL-C serum levels in FH patients. This article reviews the progress made in the 18 years since the first clinical trial for gene therapy of FH, with emphasis on the development, design, performance and limitations of viral based gene transfer vectors used in studies to ameliorate the effects of LDLR deficiency

Impact of bidirectional relationships between streptococcus anginosus group and host tissue matrix components on cellular activity: Role in establishment of infection

This paper investigates pathogenic mechanisms of the Streptococcus anginosus group (SAG) of bacteria which influence the biological activity of periodontal ligament (PDL) cells, endothelial cells and also how matrix proteins produced by these host cells influence bacterial virulence factors. Isolates of SAG species, designated S. anginosus, S. constellatus and S. intermedius, were derived from healthy commensal and clinical pathogenic infection sites. SAG culture supernatants contained multiple protein components which differed between isolates. All SAG supernatants increased cellular proliferation and decreased decorin synthesis and collagen assembly by PDL cells and reduced endothelial cell migration. SAG isolates responded differently to extracellular matrix (ECM) components synthesised by PDL cells, but there was an overall notable increase in hydrolytic enzyme activity and in the production of the cytotoxin intermedilysin by S. intermedius. Collectively, the results indicate that both commensal and pathogenic SAG isolates were capable of impairing the ability of PDL cells and endothelial cells to make functional vascularised tissue. Reduced decorin synthesis is likely to have a major impact on cell signalling, angiogenesis and matrix assembly. Furthermore, ECM components produced by PDL cells were differentially capable of moderately increasing SAG enzymic activity, leading to subtle ECM modifications. The impact this bidirectional effect has on the tissue remodelling process is discussed