Infectious Optic Neuropathies: What Should I do Differently?

Optic neuropathies commonly arise as a result of primary or secondary sequelae of infection. When present uveitis, meningitis, retinal inflammation, retinal vasculitis, orbital involvement, or sinus disease may help support an infectious etiology. Infectious agents that are known to affect the optic nerve include a long list of bacteria, virus, protozoa, or fungi. Patients may have unilateral or bilateral optic nerve disease. The optic disc may appear swollen and may be accompanied by neuroretinitis. Alternatively, the patient may present with optic neuropathy or a retrobulbar optic neuritis. Secondary optic nerve disease may also occur due to elevated intracranial pressure associated with meningeal infection. Recovery of vision is highly variable.ICopticnerveinflammationinfectio

Additional file 3 of PredictCBC-2.0: a contralateral breast cancer risk prediction model developed and validated in ~ 200,000 patients

Additional file 1: Table S3. Patient and primary breast cancer characteristics per study

Additional file 2 of PredictCBC-2.0: a contralateral breast cancer risk prediction model developed and validated in ~ 200,000 patients

Additional file 2: Table S1. Description of the studies included in the analyses

Additional file 7 of Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Additional file 7: Table S5. Lookup of all prioritized lipid genes in the Therapeutic Target Database 2022

Additional file 4 of Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Additional file 4: Table S3. Text mining results for the PoPS+ prioritized genes

Additional file 33 of Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Additional file 33: Table S22. Mouse genes with lipid phenotypes (silver set)

Additional file 10 of Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Additional file 10: Table S7. DESE phenotype-tissue association results using both GTEx gene-level and transcript-level selective expression