Phase II Study of Ifosfamide+Doxorubicin in Patients With Advanced Synovial Sarcomas (E1793): A Trial of the Eastern Cooperative Oncology Group

Purpose Because we had observed in the synovial sarcoma subgroup of a broad phase III advanced soft tissue sarcoma study a significantly greater objective regression rate from ifosfamide+doxorubicin (88%) than from doxorubicin alone (20%) (P = 0.02), the Eastern Cooperative Oncology Group (ECOG) decided to further assess this two drug combination in a subsequent Phase II study

A Case Study of Laser Wind Sensor Performance Validation by Comparison to an Existing Gage

A case study concerning validation of wind speed measurements made by a laser wind sensor mounted on a 190 square foot floating platform in Muskegon Lake through comparison with measurements made by pre-existing cup anemometers mounted on a met tower on the shore line is presented. The comparison strategy is to examine the difference in measurements over time using the paired-t statistical method to identify intervals when the measurements were equivalent and to provide explanatory information for the intervals when the measurements were not equivalent. The data was partitioned into three sets: not windy (average wind speed measured by the cup anemometers ≤ 6.7m/s) windy but no enhanced turbulence (average wind speed measured by the cup anemometers \u3e 6.7m/s), and windy with enhanced turbulence associated with storm periods. For the not windy data set, the difference in the average wind speeds was equal in absolute value to the precision of the gages and not statistically significant. Similar results were obtained for the windy with no enhanced turbulence data set and the average difference was not statistically significant (α=0.01). The windy with enhanced turbulence data set showed significant differences between the buoy mounted laser wind sensor and the on-shore mast mounted cup anemometers. The sign of the average difference depended on the direction of the winds. Overall, validation evidence is obtained in the absence of enhanced turbulence. In addition, differences in wind speed during enhanced turbulence were isolated in time, studied and explained

Phase II study of IfosfamideþDoxorubicin in patients with advanced synovial sarcomas (E1793): a trial of the Eastern Cooperative Oncology Group

Abstract Purpose Because we had observed in the synovial sarcoma subgroup of a broad phase III advanced soft tissue sarcoma study a significantly greater objective regression rate from ifosfamideþdoxorubicin (88%) than from doxorubicin alone (20%) ( P ¼ 0.02), the Eastern Cooperative Oncology Group (ECOG) decided to further assess this two drug combination in a subsequent Phase II study. Patients Between 1994 and 1999, twelve adult patients with advanced synovial sarcomas were enrolled to receive, as their initial chemotherapy, ifosfamide 7.5 gm/m 2 plus doxorubicin 60 mg/m 2 , given intravenously over two consecutive days every 3 weeks. Methods Each day for 2 days doxorubicin 30 mg/m 2 was infused over 5 min through a running i.v., followed by ifosfamide 3750 mg/m 2 over 4 h. Continuous i.v. fluid was infused at 300 mL /h for 3 h on day 1, before chemotherapy was begun; then the infusion was continued at 100 mL /h for a total of 3 days. Mesna 750 mg/m 2 was given 15 min before ifosfamide and at 4 and 8 h after ifosfamide on days 1 and 2 of each treatment cycle. Filgrastim (G-CSF) 5 mg/kg was given subcutaneously each day for 14 days beginning on day 3 of each treatment cycle to limit the severity of neutropenia. Results Five of our 12 patients (42%) experienced partial regression of their advanced synovial sarcomas; however, this first stage result was borderline for proceeding to the second planned stage of accrual and our case accrual was quite poor. Thus, the study was closed after stage one accrual. Our patients received a median of four cycles of chemotherapy (range: 1 to 6). All patients experienced at least grade 3 neutropenia (grade 4 in nine of them), and one patient died of treatment-related sepsis following the initial cycle of chemotherapy. Median survival was 11 months

Project Report No. 50, Site Index Equations for Loblolly and Slash Pine Plantations in East Texas, Update: Fall 1996

Site index prediction equations for loblolly ( Pinus taeda L.) and slash ( Pinus elliottii Engelm. ) pine plantations in East Texas

Jazz Convocation

Program listing performers and works performed

Cross-Sectional Detection of Acute HIV Infection: Timing of Transmission, Inflammation and Antiretroviral Therapy

BACKGROUND: Acute HIV infection (AHI) is a critical phase of infection when irreparable damage to the immune system occurs and subjects are very infectious. We studied subjects with AHI prospectively to develop better treatment and public health interventions. METHODS: Cross-sectional screening was employed to detect HIV RNA positive, antibody negative subjects. Date of HIV acquisition was estimated from clinical history and correlated with sequence diversity assessed by single genome amplification (SGA). Twenty-two cytokines/chemokines were measured from enrollment through week 24. RESULTS: Thirty-seven AHI subjects were studied. In 7 participants with limited exposure windows, the median exposure to HIV occurred 14 days before symptom onset. Lack of viral sequence diversification confirmed the short duration of infection. Transmission dates estimated by SGA/sequencing using molecular clock models correlated with transmission dates estimated by symptom onset in individuals infected with single HIV variants (mean of 28 versus 33 days). Only 10 of 22 cytokines/chemokines were significantly elevated among AHI participants at enrollment compared to uninfected controls, and only 4 participants remained seronegative at enrollment. DISCUSSION: The results emphasize the difficulty in recruiting subjects early in AHI. Viral sequence diversity proved accurate in estimating time of infection. Regardless of aggressive screening, peak viremia and inflammation occurred before enrollment and potential intervention. Given the personal and public health importance, improved AHI detection is urgently needed

Laser Wind Sensor Performance Validation with an Existing Gage

A new approach to laser wind sensor measurement validation is described and demonstrated. The new approach relies on the paired-t statistical method to generate a time series of differences between two sets of measurements. This series of differences is studied to help identify and explain time intervals of operationally significant differences, which is not possible with the traditional approach of relying on the squared coefficient of variation as the primary metric. The new approach includes estimating a confidence interval for the mean difference and establishing a level of meaningful difference for the mean difference, and partitioning the data set based on wind speed. To demonstrate the utility of the new approach, measurements made by a laser wind sensor mounted on a floating buoy are compared first with those made by a second laser wind sensor mounted on a nearby small island for which the co-efficient of variation is high (\u3e 99%). It was found that time intervals when high differences in wind speed occurred corresponded to high differences in wind direction supporting a hypothesis that the two laser wind sensor units are not always observing the same wind resource. Furthermore, the average difference for the 100m range gate is positive, statistically significant (α=0.01) and slightly larger than the precision of the gages, 0.1m/s. One possible cause of this difference is that the surface roughness over land is slowing the wind at 100m slightly. A second comparison was made with previously existing cup anemometers mounted on a metrological mast located on-shore. The cup anemometers are about 8m lower than the center of the lowest range gate on the laser wind sensor. The data was partitioned into three sets: not windy (average wind speed at the cup anemometers ≤ 6.7m/s) windy but no enhanced turbulence (average wind speed at the cup anemometers \u3e 6.7m/s), and windy with enhanced turbulence. Periods of enhanced turbulence are associated with the passage of a cold frontal boundary. The paired-t analysis for the not windy data set showed a difference in the average wind speeds of -0.096m/s, less in absolute value than the precision of the gages. The negative sign indicates slower wind speed over land as well as at a lower height, which is expected. Similar results were obtained for the windy with no enhanced turbulence data set. In addition, the average difference was not statistically significant (α=0.01). The windy with enhanced turbulence data set showed significant differences between the buoy mounted laser wind sensor and the on-shore mast mounted cup anemometers. The sign of the average difference depended on the direction of the winds in the periods of enhanced turbulence. Mean turbulent kinetic energy was measured to be greater when air flow into Muskegon Lake was predominantly from over land versus when air flow was predominantly from Lake Michigan. The higher mean turbulent kinetic energy for flow originating over land would likely be due to greater surface roughness experienced by the overland flow. Overall, the value of the new approach in obtaining validation evidence has been demonstrated. In this case, validation evidence is obtained in periods of no enhanced turbulence. Differences in wind speed during periods of enhanced turbulence are isolated in time, studied and are correlated in time with differences in wind direction