999 research outputs found
How Diverse Schools Affect Student Mobility: Charter, Magnet, and Newly Built Campuses in Los Angeles
Analyzes how student attributes, including race/ethnicity, language, and nativity, and school type (public, charter, pilot, magnet), size, and mix affect which students leave and which schools they transfer to. Considers pros and cons of student mobility
Teacher Stability and Turnover in Los Angeles: The Influence of Teacher and School Characteristics
Analyzes how teacher and school characteristics - including demographics, quality and qualification, specialty, school type (public, magnet, charter) and size, academic climate, and teacher-student racial match - influence teacher turnover
Proteins Do Not Have Strong Spines After All
In this issue of Structure, Berkholz et al. show that the detailed backbone geometry of proteins depends on the local conformation and suggest how this information can be practically used in modeling and refining protein structures
N-{N-[2-(3,5-Difluorophenyl)acetyl]-(S)-alanyl}-(S)-phenylglycine tert-butyl ester (DAPT): an inhibitor of γ-secretase, revealing fine electronic and hydrogen-bonding features
The title compound, C23H26F2N2O4, is a dipeptidic inhibitor of γ-secretase, one of the enzymes involved in Alzheimer’s disease. The molecule adopts a compact conformation, without intramolecular hydrogen bonds. In the crystal structure, one of the amide N atoms forms the only intermolecular N—H⋯O hydrogen bond; the second amide N atom does not form hydrogen bonds. High-resolution synchrotron diffraction data permitted the unequivocal location and refinement without restraints of all H atoms, and the identification of the characteristic shift of the amide H atom engaged in the hydrogen bond from its ideal position, resulting in a more linear hydrogen bond. Significant residual densities for bonding electrons were revealed after the usual SHELXL refinement, and modeling of these features as additional interatomic scatterers (IAS) using the program PHENIX led to a significant decrease in the R factor from 0.0411 to 0.0325 and diminished the r.m.s. deviation level of noise in the final difference Fourier map from 0.063 to 0.037 e Å−3
Carrying out an optimal experiment
Diffraction data collection parameters leading to optimal data quality are discussed in the context of different applications of these data
SU(2) Cosmological Solitons
We present a class of numerical solutions to the SU(2) nonlinear
-model coupled to the Einstein equations with cosmological constant
in spherical symmetry. These solutions are characterized by the
presence of a regular static region which includes a center of symmetry. They
are parameterized by a dimensionless ``coupling constant'' , the sign of
the cosmological constant, and an integer ``excitation number'' . The
phenomenology we find is compared to the corresponding solutions found for the
Einstein-Yang-Mills (EYM) equations with positive (EYM). If
we choose positive and fix , we find a family of static spacetimes
with a Killing horizon for . As a limiting solution
for we find a {\em globally} static spacetime with
, the lowest excitation being the Einstein static universe. To
interpret the physical significance of the Killing horizon in the cosmological
context, we apply the concept of a trapping horizon as formulated by Hayward.
For small values of an asymptotically de Sitter dynamic region contains
the static region within a Killing horizon of cosmological type. For strong
coupling the static region contains an ``eternal cosmological black hole''.Comment: 20 pages, 6 figures, Revte
Impact of synchrotron radiation on macromolecular crystallography: a personal view
This article, largely based on personal experiences of the authors, reviews the early history of the application of synchrotron radiation to structural biology, and particularly protein crystallography, to show the tremendous impact that this experimental innovation has had on these disciplines
Fernüberwachungs- und Bediensysteme für Selbstbedienungsschleusen am Beispiel der Schleuse Neu Kaliß
Solvent content of protein crystals from diffraction intensities by Independent Component Analysis
An analysis of the protein content of several crystal forms of proteins has
been performed. We apply a new numerical technique, the Independent Component
Analysis (ICA), to determine the volume fraction of the asymmetric unit
occupied by the protein. This technique requires only the crystallographic data
of structure factors as input.Comment: 9 pages, 2 figures, 1 tabl
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