Respiratory, Neurological and Other Health Outcomes among Plastic Factory Workers in Gazipur, Bangladesh

Background: Approximately three thousand plastic goods manufacturing factories (PGMF) are currently operating in Bangladesh involving numerous workers. Associated health problems of these workers are largely unknown. The key objectives of the current study were identifying plastic chemical exposures related health outcomes in these workers and comparing these outcomes before and after their joining in PGMFs. In addition, we aimed to investigate the relationships between work duration and the prevalence of health ailments among workers. Method: A cross-sectional study was carried out among factory workers (n=405) at six PGMFs in Gazipur district in Bangladesh. A simple random sampling method had been applied to select participants and data on their self-reported exposures to chemicals and associated respiratory, neurological, and other multiple health outcomes were collected through a validated questionnaire survey. Data were analyzed using different descriptive and inferential statistical tools. The categorical variables and continuous variables were interpreted using frequency distribution and standard deviation (SD) respectively. A Pearson chi-square (χ2) test was applied to evaluate the correlation between work duration and health outcomes. A p-value Results: The average age and work duration of the workers were 25.63±6.85 and 3.49±3.53 years, respectively, implying that most workers were young, and spent over 10% of their lifetime in PGMFs work. Most common health outcomes reported by the workers were nasal discharges: 60 (14.9%), headaches: 76 (18.9%), fatigues: 112 (27.8%), losses of appetites: 108 (26.8%), urination problems: 61 (13.1%), losses of body weights: 102 (25.3%), and nervousness: 70 (17.4%). Among the common health outcomes only headache (p=0.005); fatigue (p=0.04); urination problem (p=p=0.004) were significantly associated with the work duration. Furthermore, except for hypertension and tarry stool, all health outcomes among workers differ significantly before and after joining in PGMFs. Conclusion: This study first time identified important health outcomes of the PGMFs workers and generated baseline information on common health outcomes of the PGMFs workers in developing countries like Bangladesh. However, it might be important to identify potential causes of such health outcomes in PGMFs workers considering both biomarkers of exposures and real-time environmental samples to understand the disease pathology and to recommend mitigation measures to be taken by occupational health policymakers and practitioners in developing countries

Twelfth rib syndrome: role of intercostal blocks: case series of 10 patients

Twelfth rib syndrome (TRS) is a rare condition that causes severe pain in the loin. It is often misdiagnosed, leading to unnecessary investigations and treatments. Intercostal blocks in the 11th and 12th rib often resolve the pain for these patients. In this research paper, we aim to explore the role of intercostal block in the management of TRS based on our experience with 10 patients. Data of patients who were diagnosed with TRS were studied retrospectively from our hospital records who have been given intercostal block injection from the period of Jan 2022 to August 2023 as an audit.  Four patients underwent intercostal blocks. VAS scores were measured in follow-up for 1 and 3 months. 4 patients were lost to follow up and hence not considered in this study. The male to female ratio was 7:3. There was a statistically significant reduction in VAS score at 1 month and 3 months compared to pre-injection times. Patients who have failed conservative management for TRS can be effectively managed with intercostal block injections

Cost benefit analysis of intralesional injections in keloids using Luer lock and non-locking syringes

Background: For keloid scarring, intralesional corticosteroid injections continue to be the most often utilised first therapeutic option. This is a common procedure done on an outpatient basis by surgeons and orthopaedists. Luer lock syringes which lock the needle with syringe prevent any leakage or spillage of drug while pushing it near the keloid compared to normal syringes. Methods: We intend to do a cost benefit analysis based on the retrospective data of intralesional steroid injections done by the authors (AP and SK) in their private practice. Results: The time between 2021 to 2022, 200 injection data was retrieved, 100 each using non locking syringes and Luer lock syringes. The spillage rate with non-Luer lock syringes was 14%. Conclusions: We found that luer lock syringes prove to be cost effective after giving more than 200 injections in keloids than non-locking syringes.

A review of non-mosquito vector-borne and zoonotic pathogens of public health importance in Bangladesh.

Background: Bangladesh is the 8th most populated country in the world located in South-East Asia. Non-mosquito vector-borne diseases (NMVBD) are very common; however, their impact on public and veterinary health is not fully known. Purpose: The objective of this comprehensive review is to summarize published NMVBD data and determine the present status and extent of knowledge about them in Bangladesh. Methods: PubMed and Google Scholar were searched using a combination of the title-based keywords. Each article has been read and objectives-based information was extracted and tabulated. Both human and animal data have been collected to measure zoonotic importance. Results: Twenty articles have been selected for this review. These articles published in 2012 to 2020 reported detection of or exposure to vector-borne pathogens in livestock or in humans, analysis of ectoparasites or broader studies based on One-Health approach. Molecular methods were broadly used, alone (n=7, 35%) or in combination with other laboratory procedures (n=10). Three papers (15%) reported only microscopy-based detection of Babesia, Theileria and Anaplasma marginale in blood of livestock and rodents. Two country-wide serosurveys of patients reported human exposure to Orientia tsutsugamushi (8.75% to 23.7%) and typhus and spotted fever group rickettsiae (19.7% to 66.6%), and Coxiella burnetii (3%). PCR-based studies confirmed that febrile patients in Bangladesh may be infected with O. tsutsugamushi, Rickettsia typhi, R. felis or Bartonella elizabethae. PCR-confirmed canine infections with Babesia gibsonii (30%), A. bovis (58%), or R. monacensis (14%, n=50) and feline infections with R. felis (21%, n=100). Testing of ectoparasites removed from cats, dogs and cattle identified high positivity rates for many human and veterinary pathogens. Conclusion: This review provides a baseline summary of current knowledge of NMVBD diseases in Bangladesh and should stimulate surveillance of the veterinary and human diseases and setting up research priorities pertaining to the status of these infections

Effect of Some Soil Conditioners on Water-Use Efficacy, Growth, and Yield of Date Palm Siwi Grown in Sandy Soil under Different Irrigation Regimes to Mitigate Climate Change

A field experiment was carried out at Al-Bahariya Oasis, Giza, Egypt, during three successive seasons to find out the effect of application of bentonite (BN) as a natural clay deposit at either 6 or 12 kg/palm tree and humic substances (HS) as organic amendment at either 0.75 or 1.0 L/palm tree incorporated with Bacillus polymyxa (BP) as a biofertilizers at 14 and 28 mL/L rates on growth, yield, and fruit weight of 10-year-old Siwi date palm cv. (Phoenix dectylifera L.). Siwi trees were cultivated in sandy texture soil at a distance of 8 × 8 m and were irrigated with 100%, 85%, and 70% of ET crop. Effects of the previous treatments on growth, date palm crop, soil properties, water relations, water-use efficiency (WUE), and economic return were also studied. The obtained results showed that the mean values of leaf length, leaflet length and width, fruit set%, bunch weight, yield/palm, yield/fed, fruit weight, flesh weight, and fruit pulp weight were increased in response to the different individual and combined treatments used in this study with various significance levels compared to the control treatment means in the studied three seasons. However, the superiority was for combining between amending the sandy soil with either low concentrations of BN (6 kg/tree) + HS (0.75 Liter/tree) + BP (14 mL/L) or high concentrations of BN (12 kg/tree) + HS (1.0 L/tree) + BP (28 mL/L) and irrigation with 85% of ETc water level, as such combinations attained the highest values in most of the mentioned values over both the sole and combined treatments in the studied three seasons. Furthermore, the results indicated that the highest monthly ETc values occurred during June and July months, while the lowest values occurred during December and January months. Additionally, water productivity (WP) increased considerably by reduction of water quantity (70% ETc) associated with soil conditioner treatment (BN.12 kg +HS 1 L + BP. 28 mL/L), and values were 2.17, 2.25, and 2.27 kg fruit/m3 of water irrigation during the growing seasons, respectively. The highest net return was attributed to irrigation with 85% of ETc water level along with the application of soil conditioners at high rates. Accordingly, it is advisable to apply the soil conditioners of bentonite (at 6 or 12 kg/tree) and humic substances (at either 0.75 or 1.0 L/tree) with B. polymyxa (at either 14 or 28 mL/L) plus irrigation with either 85% or 70% of ETc water level to obtain the best growth, highest yield, (WP), and gross return from var. Siwi date palm grown under an oasis agro-system

The Re-Emergence of Mpox: Old Illness, Modern Challenges

The Mpox virus (MPXV) is known to cause zoonotic disease in humans. The virus belongs to the genus Orthopoxvirus, of the family Poxviridae, and was first reported in monkeys in 1959 in Denmark and in humans in 1970 in the Congo. MPXV first appeared in the U.S. in 2003, re-emerged in 2017, and spread globally within a few years. Wild African rodents are thought to be the reservoir of MPXV. The exotic trade of animals and international travel can contribute to the spread of the Mpox virus. A phylogenetic analysis of MPXV revealed two distinct clades (Central African clade and West African clade). The smallpox vaccine shows cross-protection against MPXV infections in humans. Those who have not previously been exposed to Orthopoxvirus infections are more vulnerable to MPXV infections. Clinical manifestations in humans include fever, muscle pain, headache, and vesicle formation on the skin of infected individuals. Pathognomonic lesions include ballooning degenerations with Guarnieri-like inclusions in vesicular epithelial cells. Alterations in viral genome through genetic mutations might favor the re-emergence of a version of MPXV with enhanced virulence. As of November 2023, 92,783 cases and 171 deaths have been reported in 116 countries, representing a global public health concern. Here, we provide insights on the re-emergence of MPXV in humans. This review covers the origin, emergence, re-emergence, transmission, pathology, diagnosis, control measures, and immunomodulation of the virus, as well as clinical manifestations. Concerted efforts of health professionals and scientists are needed to prevent the disease and stop its transmission in vulnerable populations