TLR Signaling on Protozoan and Helminthic Parasite Infection

Toll-like receptors (TLRs), a major component of innate immune system, are expressed as membrane or cytosolic receptors on neutrophils, monocytes, macrophages, dendritic cells (DCs), B lymphocytes, Th1, Th2, and regulatory T lymphocytes. It recognizes pathogen-associated molecular patterns (PAMPs) and Toll-interleukin1 (IL-1) receptor (TIR) of various invading pathogens. Downstream signaling of TLRs activates NF-κB, which acts as a transcription factor of pro-inflammatory cytokines, chemokines, and costimulatory molecules. A balance between pro- and anti-inflammatory cytokine protects host body from infectious agents and also induces the healing process. Some of parasitic infections by protozoans and helminths such as Malaria, Leishmaniasis, Trypanosomiasis, Toxoplasmosis, Amoebiasis, Filariasis, Schistosomiasis, Ascariasis, Taeniasis, and Fasciolosis are the leading cause of death and economic loss in both developing and developed nations. Frequent exposure to parasites, immigration, refugee resettlement, increasing immunodeficiency, climate change, drug resistance, lack of vaccination, etc. are the major cause of emerging and re-emerging of the above-stated diseases. However, TLR activation by parasites could stimulate antigen presenting cells and ultimately clear the pathogens by phagocytosis. So, a better understanding of host-parasite interaction in relation to TLR signaling pathway will improve the controlling method of these pathogens in immunotherapy

Impact of water deficit stress on biomass production of different gladiolus cultivars under rainfed condition

Among the environmental stresses, water deficit stress was recognized to be one of the most adverse factors for plant growth and productivity. The study aimed to comparatively evaluate impact of water deficit stress on biomass of seven cultivars of gladiolus in terms of leaf area duration and net assimilation rate under rainfed conditions in northeastern region of India. Also, productions in terms of marketable spikes were compared. The parameters were measured using standard procedures. Comparatively higher leaf area duration (116 days) and net assimilation rate were found in cultivars Aarti (116 days and1.62 gcm-2day-1x10-3 respectively) and Suchitra (98.0 days and 1.10 gcm-2day-1x10-3) which account for their higher biomass production with larger spike size with good numbers of flowers. The highest marketable spikes (71111.11 spikes ha-1) was found in cultivar Aarti followed by Suchitra (68148.14 spikes ha-1) which might be due to its comparatively higher biomass production and less deviation, during stress condition, from normal characteristics. The tolerant cultivars are those that can adapt to the change without much change in their normal growth. And the responses of those species are commercially acceptable that promote adaptation without compromising much with the plant growth and crop production

An Insight into the Changing Scenario of Gut Microbiome during Type 2 Diabetes

The gut microbiome consists of bacteria, protozoans, viruses, and archaea collectively called as gut microbiota. Gut microbiome (GM) modulates a variety of physiological responses ranging from immune and inflammatory responses, neuronal signalling, gut barrier integrity and mobility, synthesis of vitamins, steroid hormones, neurotransmitters to metabolism of branched-chain aromatic amino acids, bile salts, and drugs. Type 2 diabetes mellitus (T2D) is a highly prevalent metabolic disorder that is featured by imbalance in blood glucose level, altered lipid profile, and their deleterious consequences. GM dysbiosis a major factor behind the incidence and progression of insulin resistance and is responsible for altering of intestinal barrier functions, host metabolic, and signaling pathways. The GM of type 2 diabetes (T2DM) patients is characterized by reduced levels of Firmicutes and Clostridia and an increased ratio of Bacteroidetes:Firmicutes. Endotoxemia stimulates a low-grade inflammatory response, which is known to trigger T2DM. Xenobiotics including dietary components, antibiotics, and nonsteroidal anti-inflammatory drugs strongly affect the gut microbial composition and can promote dysbiosis. However, the exact mechanisms behind the dynamics of gut microbes and their impact on host metabolism are yet to be deciphered. Interventions that can restore equilibrium in the GM have beneficial effects and can improve glycemic control

Microstructure and Crystallographic Texture of Aluminium Composite

The objective of the present work is to study the hot deformation behaviour of Al alloy-SiC Composites and to analyze the microstructure and crystallographic texture. Dispersing finer size hard particles in Al alloys restricted the flow of grains and tends to alter the texture. Al composites were homogenized and subjected to compression test using universal testing machine at various strain rates and temperatures. The deformed microstructure was studied under microscope paying particular emphasis to understand the mechanism of material flow. The crystallographic texture of the deformed samples was found out using x-ray diffactometer. The results depict that Al composites can safely be deformed at 400 oC and at 0.01 /s strain rate and the microstructure shows dynamic recrystallization as the predominant mechanism of material flow.  It was also observed that at higher strain rate (10/s) of deformation, the interface decohesion between the metallic matrix and ceramic phase was observed.  Adiabatic shear bands (localized flow) were observed when the materials deformed at room temperature (30 oC) and at strain rate of 0.01/s.  The texture measurement of Al composites, at the safe region, shows the components of (011) [100], (001) [1-10], (010) [101].  This study indicated that Goss and cube texture are favorable for the easy deformation of Al composite

Early performance of cocoa (Theobroma cacao L.)genotypes in arecanut under Assam condition of North Eastregion of India

Cocoa is an important plantation crop grown in southern parts of India. Though many cocoa varieties have been released for cultivation in different parts of India, there is no variety recommended for cultivation exclusively for India’s North East region, especially Assam, where arecanut is grown as an important cash crop. Therefore the present investigation was undertaken to study the performance of twelve cocoa genotypes for its growth, pod yield and yield attributing traits for subsequent research programmes. The data for growth, pod yield and yield attributing traits were recorded three years after planting for five years (2015 to 2019), and the mean data were used for analysis. Genotype VTLC 11 significantly produced greater plant height (2.70 m), stem circumference (27.73 cm), height at jorquetting (36.16 cm) and canopy area (17.00 m2). Mean average pod yield among the genotypes varied from 20.65 to 48.40 tree-1 year-1. Genotype VTLC 19 produced significantly higher pod yield (48.40), number of fresh beans pod-1 (34.06), fresh bean weight pod-1 (229.65 g), dry bean weight pod-1 (119.32 g), single dry bean weight (1.20 g) and dry bean yield (1.76 kg). Considering the most economic traits of cocoa, VTLC 19 appears to be the most suitable genotype for commercial cultivation in the region

Efficacy of expressed breast milk alone or in combination with paracetamol in reducing pain during retinopathy of prematurity screening: A randomized controlled trial

Background: The aim of this study was to determine the efficacy of expressed breast milk (EBM) alone or in combination with oral paracetamol for pain reduction during retinopathy of prematurity (ROP) screening.  Methods: A randomized control trial was conducted in two departments of Bangabandhu Sheikh Mujib Medical University. A total of 60 preterm neonates who underwent ROP screening were randomized into three equal groups. Group A got nesting and swaddling as per institutional protocol (control). Group B received 2 ml EBM two minutes prior to the ROP screening and Group C received 15 mg/kg syrup paracetamol 30 minutes prior to the ROP screening and EBM like Group B. Premature infant pain profile (PIPP) scores was used prior, during and 2 minutes after ROP screening procedure. Results: The three groups were similar in terms of baseline characteristics. The mean (standard deviation) PIPP scores during the procedure were 16.4 (1.1), 15.0 (1.8) and 13.4 (1.8) in control, EBM, and EBM with paracetamol groups respectively. The PIPP scores were significantly lower in the EBM and EBM with paracetamol groups during the procedure compared to control group. In the EBM and EBM with paracetamol groups, the mean difference in PIPP scores (between before and during the procedure) was also substantially lower. Conclusion: Breast milk alone or in combination with paracetamol can reduce significant pain during ROP screening than control group. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(2): 106-11

Performance of the CMS High Granularity Calorimeter prototype to charged pion beams of 20−-300 GeV/c

The upgrade of the CMS experiment for the high luminosity operation of the LHC comprises the replacement of the current endcap calorimeter by a high granularity sampling calorimeter (HGCAL). The electromagnetic section of the HGCAL is based on silicon sensors interspersed between lead and copper (or copper tungsten) absorbers. The hadronic section uses layers of stainless steel as an absorbing medium and silicon sensors as an active medium in the regions of high radiation exposure, and scintillator tiles directly readout by silicon photomultipliers in the remaining regions. As part of the development of the detector and its readout electronic components, a section of a silicon-based HGCAL prototype detector along with a section of the CALICE AHCAL prototype was exposed to muons, electrons and charged pions in beam test experiments at the H2 beamline at the CERN SPS in October 2018. The AHCAL uses the same technology as foreseen for the HGCAL but with much finer longitudinal segmentation. The performance of the calorimeters in terms of energy response and resolution, longitudinal and transverse shower profiles is studied using negatively charged pions, and is compared to GEANT4 predictions. This is the first report summarizing results of hadronic showers measured by the HGCAL prototype using beam test data.Comment: To be submitted to JINS

Observation of the Rare Decay of the η Meson to Four Muons

A search for the rare η→μ+μ−μ+μ− double-Dalitz decay is performed using a sample of proton-proton collisions, collected by the CMS experiment at the CERN LHC with high-rate muon triggers during 2017 and 2018 and corresponding to an integrated luminosity of 101  fb−1. A signal having a statistical significance well in excess of 5 standard deviations is observed. Using the η→μ+μ− decay as normalization, the branching fraction B(η→μ+μ−μ+μ−)=[5.0±0.8(stat)±0.7(syst)±0.7(B2μ)]×10−9 is measured, where the last term is the uncertainty in the normalization channel branching fraction. This work achieves an improved precision of over 5 orders of magnitude compared to previous results, leading to the first measurement of this branching fraction, which is found to agree with theoretical predictions