What works in education in Pakistan, and why? The case of PDCN’s whole school improvement program in Gilgit-Baltistan of Pakistan

This inquiry is part of a country-wide study conducted to explore What Works in Education in Pakistan, and Why? The Whole School Improvement Programme (WSIP) of Aga Khan University-Professional Development Center, North (AKU-PDCN) offered in Gilgit-Baltistan is one of the seven cases chosen based on its best practices in teacher professional development and school improvement in the mountainous and rural Gilgit-Baltistan of Pakistan. Three schools representing the public, private and AKESP systems were selected for this study. The findings emanating from the three cases have been structured and discussed under the themes of „Teachers Professional Development,‟ „School-Community Relations,‟ „Monitoring and Evaluation,‟ and „Gender.‟ The cross-case analysis, however, reflects three overarching themes of „Role of Leadership in School Improvement,‟ „Role of Continuing Professional Development of Teachers,‟ and Community Participation.‟ There is tangible evidence to support the claim that WSIP is an effective and viable model of school improvement in the context of Gilgit-Baltistan, and elsewhere

Expressive amusia and aphasia: the story of Maurice Ravel

ABSTRACT The French composer, Maurice Ravel, at the peak of his career, showed signs of a progressive disorder that affected his ability to function with verbal and musical language, as noted by the neurologist Théophile Alajouanine. The worsening of the disease led to a craniotomy, performed in 1937, which failed to reveal the cause of his illness, and he died shortly thereafter. A lack of post-mortem neuropathological evidence precluded a definitive diagnosis of the illness, which remained enigmatic. Speculations about the precise diagnosis of Ravel's neurological disease have been largely based on Alajouanine's observations, which included aphasia and amusia, mostly expressive, and ideomotor apraxia, while musical judgement, taste, and memory remained relatively intact, implying different neuroanatomical substrates. A possible subform of frontotemporal lobar degeneration complex was the diagnostic suggestion of many authors. His untimely death deprived the world of this remarkable musician, and the music that remained trapped in his mind

Targeting butyrylcholinesterase for preclinical single photon emission computed tomogrpahy (SPECT) imaging of Alzheimer's disease

Published version.Abstract Introduction Diagnosis of Alzheimer's disease (AD) in vivo , by molecular imaging of amyloid or tau, is constrained because similar changes can be found in brains of cognitively normal individuals. Butyrylcholinesterase (BChE), which becomes associated with these structures in AD, could elevate the accuracy of AD diagnosis by focusing on BChE pathology in the cerebral cortex, a region of scant BChE activity in healthy brain. Methods N -methylpiperidin-4-yl 4-[123 I]iodobenzoate, a BChE radiotracer, was injected intravenously into B6SJL-Tg(APPSwFlLon, PSEN1∗M146 L∗L286 V) 6799Vas/Mmjax (5XFAD) mice and their wild-type (WT) counterparts for comparative single photon emission computed tomogrpahy (SPECT) studies. SPECT, computed tomography (CT), and magnetic resonance imaging (MRI) enabled comparison of whole brain and regional retention of the BChE radiotracer in both mouse strains. Results Retention of the BChE radiotracer was consistently higher in the 5XFAD mouse than in WT, and differences were particularly evident in the cerebral cortex. Discussion Cerebral cortical BChE imaging with SPECT can distinguish 5XFAD mouse model from the WT counterpart

Human serum cholinesterase from liver pathological samples exhibit highly elevated aryl acylamidase activity.

These findings establish AAA(BChE) as an independently regulated enzymatic activity on BChE especially in liver disorders. Moreover, since neither the low esterase activity of BChE by itself nor increased levels of AST/gamma GT are sufficient pathological indicators, this pilot study merits replication with large sample numbers

Phenothiazines as dual inhibitors of SARS-CoV-2 main protease and COVID-19 inflammation

COVID-19, caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2) currently has no treatment for acute infection. The main protease (Mpro) of SARS-CoV-2 is an essential enzyme for viral replication and an attractive target for disease intervention. The phenothiazine moiety has demonstrated drug versatility for biological systems, including inhibition of butyrylcholinesterase, a property important in the cholinesterase anti-inflammatory cascade. Nineteen phenothiazine drugs were investigated using in silico modelling techniques to predict binding energies and inhibition constants (Ki values) with SARS-CoV-2 Mpro. Since most side-effects of phenothiazines are due to interactions with various neurotransmitter receptors and transporters, phenothiazines with few such interactions were also investigated. All compounds were found to bind to the active site of SARS-CoV-2 Mpro and showed Ki values ranging from 1.30 to 52.4 M. Nine phenothiazines showed inhibition constantsThe accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author