Optimization of metallurgical material purchase

Tato diplomová práce se zabývá optimalizací procesu nákupu a dělení hutníno materiálu s použitím řešení úlohy o optimálním dělení materiálu, jednou z úloh lineárního programování. Cílem při řešení této úlohy je minimalizace odpadu a minimalizace nákladů na nákup výchozího materiálu. Návrh řešení je určen pro podmínky společnosti KULIČKOVÉ ŠROUBY KUŘIM,a.s. Základem práce je cyklus PDCA Edwardsa Deminga („plánuj-dělej-kontroluj-jednej“) jako základní způsob pro efektivní řešení a zlepšování výrobních aktivit, procesů a systému.This diploma thesis deals with optimization of process metallurgical material purchase and cutting with use of the problem solving of optimal material dividing, which is one of the linear programming problems. The aim of this problem solving is to minimize waste and to minimize the purchase costs for base material. The solution of this problem has the practical application at the company KULICKOVE SROUBY KURIM,a.s. This work is based on Deming Cycle (“Plan-Do-Check-Act”), as the basic method of solution efficiency and operations, processes and systems improvement.

ESG financing instruments in the context of sustainable development of regional infrastructure

The work proves the importance of the ESG approach in implementing the goals and objectives of the sustainable development strategy of a modern bank, which is an integral element of its overall strategy. Attention is paid to the basic tools and principles of responsible financing in the practice of Russian credit institutions. It has been proven that, following their own model of corporate social responsibility, banks participate in the development of infrastructure, industries and areas of activity at the regional level, helping to increase the investment attractiveness of territories and their spatial development

Study of the level of physical fitness of young acrobat athletes at the initial stage of training

Purpose: determine the level of physical preparedness of young acrobat athletes of the first year of training. Material & Methods: the study was conducted on the basis of the Integrated Children's Sports School No. 6 of the Sloboda district (Kharkiv). The study involved 16 children 5–6 years old, engaged in sports acrobatics in sports and fitness groups. Enrollment in primary training groups was carried out in accordance with the regulations established by the administration of the children's sports school. Pedagogical testing of physical and functional-motor readiness of children was carried out using tests provided by the State standard of sports training in sports acrobatics to assess general and special physical preparedness. The level of speed strength, special flexibility in the hip joint and spinal column, dynamic strength, speed, static strength were determined. Results: using correlation analysis, it was established that there are interconnections of a predominantly average level between the indicators of general and special physical preparedness of young athletes. Conclusions: studies have established that young beginner acrobats have a high level of flexibility, other indicators of physical qualities have heterogeneous results, mainly of an average level of correlation between exercises of general and special physical fitness

DETERMINATION OF THE INFLUENCE OF THE EXPERIMENTAL PROGRAM OF BASIC ELEMENTS ON THE FORMATION OF THE FACTOR STRUCTURE OF THE ASSIMILATION OF SPORTS ACROBATICS BY YOUNG NOVICE ATHLETES

Purpose: to study the influence of the experimental program on the formation of the factor structure of mastering the basic elements of the technique of young acrobats 6-7 years old. Material and methods: the study involved young novice acrobats 6-7 years old school №4 in the amount of 19 people (10 guys and 9 girls). General and specific physical exercises and psychophysiological characteristics were used as tests. The factor analysis of the calculation was used, which was carried out by the statistical method developed and presented in the works of S. Spearman and G. Thompson. Results: the conducted factor analysis made it possible to determine a number of factors that determine the quality of mastering the basic elements of sports acrobatics techniques by young athletes of 6-7 years old. Conclusions: it was found that in the process of applying the experimental program, a redistribution of factors was carried out: 4 groups of factors were identified: psychophysiological, general preparatory, specially preparatory and others n basic exercises ("swallow", "bridge", "standing on the shoulder blades, "forward roll", "wheel") in the direction of performing special preparatory exercises.  Keywords: sports acrobatics, basic exercises, young acrobats

USE OF SPECIAL PREPARATORY EXERCISES FOR MASTERING THE BASIC ELEMENTS OF SPORTS ACROBATICS BY YOUNG ATHLETES 7-9 YEARS OLD

Purpose: to develop complexes of special preparatory exercises and determine the effectiveness of their use in mastering basic exercises for beginners acrobats.Material and methods: research was carried out on the basis of the Complex Children's Sports School No. 6, Slobodsky District (Kharkov). The study involved 28 children 6-7 years old, engaged in sports acrobatics in sports and health groups. The control group (n=14) conducted the training process according to the CYSS program, experimental (n=14) with the use of special exercises for each basic element ("swallow", "standing on the shoulder blades", "birch", "forward roll", "cartwheel", "bridge stand"), in the preparatory part of the lesson. At the end of the annual training, control testing of the implementation of the basic elements of young acrobats of 6-7 years old of the studied groups was carried out, which was assessed by 5 experts according to a 10-point assessment of their implementation.Results: in the process of using complexes of special exercises for each basic element of young acrobats 6-7 years old, reliably better assessment results were obtained in relation to the control group in performing exercises "swallow" (t=6,25; p<0,001), "standing on the shoulder blades" (t=7,89; p<0,001), "forward roll" (t=4,00; p<0,001), "cartwheel" (t=4,69; p<0,001) and "bridge stand" (t=4,33; p <0,001).Conclusions: as a result of the research, it was found that the use of the developed complexes of special exercises for mastering the basic elements by young acrobats of 6-7 years old effectively influences the formation of the elements of the technique of basic exercises and psychophysiological indicators, ensures their implementation

Towards the Baikal Open Laboratory in Astroparticle Physics

The open science framework defined in the German-Russian Astroparticle Data Life Cycle Initiative (GRADLCI) has triggered educational and outreach activities at the Irkutsk State University (ISU), which is actively participated in the two major astroparticle facilities in the region: TAIGA observatory and Baikal-GVD neutrino telescope. We describe the ideas grew out of this unique environment and propose a new open science laboratory based on education and outreach as well as on the development and testing new methods and techniques for the multimessenger astronomy

The New General Biological Property of Stem-like Tumor Cells (Part II: Surface Molecules, Which Belongs to Distinctive Groups with Particular Functions, Form a Unique Pattern Characteristic of a Certain Type of Tumor Stem-like Cells)

An ability of poorly differentiated cells of different genesis, including tumor stem-like cells (TSCs), to internalize extracellular double-stranded DNA (dsDNA) fragments was revealed in our studies. Using the models of Krebs-2 murine ascites carcinoma and EBV-induced human B-cell lymphoma culture, we demonstrated that dsDNA internalization into the cell consists of several mechanistically distinct phases. The primary contact with cell membrane factors is determined by electrostatic interactions. Firm contacts with cell envelope proteins are then formed, followed by internalization into the cell of the complex formed between the factor and the dsDNA probe bound to it. The key binding sites were found to be the heparin-binding domains, which are constituents of various cell surface proteins of TSCs—either the C1q domain, the collagen-binding domain, or domains of positively charged amino acids. These results imply that the interaction between extracellular dsDNA fragments and the cell, as well as their internalization, took place with the involvement of glycocalyx components (proteoglycans/glycoproteins (PGs/GPs) and glycosylphosphatidylinositol-anchored proteins (GPI-APs)) and the system of scavenger receptors (SRs), which are characteristic of TSCs and form functional clusters of cell surface proteins in TSCs. The key provisions of the concept characterizing the principle of organization of the “group-specific” cell surface factors of TSCs of various geneses were formulated. These factors belong to three protein clusters: GPs/PGs, GIP-APs, and SRs. For TSCs of different tumors, these clusters were found to be represented by different members with homotypic functions corresponding to the general function of the cluster to which they belong

Identification of the xenograft and its ascendant sphere-forming cell line as belonging to EBV-induced lymphoma, and characterization of the status of sphere-forming cells

Abstract Background We have characterized the human cell line arised from the Epstein–Barr virus (EBV) positive multiple myeloma aspirate subjected to the long-term cultivation. This cell line has acquired the ability to form free-floating spheres and to produce a xenograft upon transplantation into NOD/SCID mice. Methods Cells from both in vitro culture and developed xenografts were investigated with a number of analytical approaches, including pathomorphological analysis, FISH analysis, and analysis of the surface antigens and of the VDJ locus rearrangement. Results The obtained results, as well as the confirmed presence of EBV, testify that both biological systems are derived from B-cells, which, in turn, is a progeny of the EBV-transformed B-cellular clone that supplanted the primordial multiple myeloma cells. Next we assessed whether cells that (i) were constantly present in vitro in the investigated cell line, (ii) were among the sphere-forming cells, and (iii) were capable of internalizing a fluorescent TAMRA-labeled DNA probe (TAMRA+ cells) belonged to one of the three types of undifferentiated bone marrow cells of a multiple myeloma patient: CD34+ hematopoietic stem cells, CD90+ mesenchymal stem cells, and clonotypic multiple myeloma cell. Conclusion TAMRA+ cells were shown to constitute the fourth independent subpopulation of undifferentiated bone marrow cells of the multiple myeloma patient. We have demonstrated the formation of ectopic contacts between TAMRA+ cells and cells of other types in culture, in particular with CD90+ mesenchymal stem cells, followed by the transfer of some TAMRA+ cell material into the contacted cell

Abstracts of The Second Eurasian RISK-2020 Conference and Symposium

This abstract book contains abstracts of the various research ideas presented at The Second Eurasian RISK-2020 Conference and Symposium.The RISK-2020 Conference and Symposium served as a perfect venue for practitioners, engineers, researchers, scientists, managers and decision-makers from all over the world to exchange ideas and technology about the latest innovation developments dealing with risk minimization