Lymph node involvement by enteropathy-like indolent NK-cell proliferation.

Natural killer (NK)-cell enteropathy (NKCE) and lymphomatoid gastropathy (LG) are closely related lymphoproliferative disorders (LPDs) composed of mature and Epstein-Barr virus (EBV)-negative NK-cells. Although these uncommon and indolent lymphoid proliferations mostly arise within the gastrointestinal (GI) tract as their designations implies, a few cases have been reported outside the GI tract. We hereby describe a unique case of lymph node infiltration by such EBV-negative NK-cell proliferation fortuitously found during routine examination of a gallbladder resected for biliary lithiasis. The histologic, phenotypic, and molecular features of this NK-cell proliferation, which were very similar if not identical to those previously reported in NKCE or LG, suggest that similar indolent EBV-negative NK-cell LPDs may also occasionally involve lymph nodes

Identifying magnetic reconnection in 2D Hybrid Vlasov Maxwell simulations with Convolutional Neural Networks

Magnetic reconnection is a fundamental process that quickly releases magnetic energy stored in a plasma.Identifying, from simulation outputs, where reconnection is taking place is non-trivial and, in general, has to be performed by human experts. Hence, it would be valuable if such an identification process could be automated. Here, we demonstrate that a machine learning algorithm can help to identify reconnection in 2D simulations of collisionless plasma turbulence. Using a Hybrid Vlasov Maxwell (HVM) model, a data set containing over 2000 potential reconnection events was generated and subsequently labeled by human experts. We test and compare two machine learning approaches with different configurations on this data set. The best results are obtained with a convolutional neural network (CNN) combined with an 'image cropping' step that zooms in on potential reconnection sites. With this method, more than 70% of reconnection events can be identified correctly. The importance of different physical variables is evaluated by studying how they affect the accuracy of predictions. Finally, we also discuss various possible causes for wrong predictions from the proposed model.Comment: 16 pages, 9 figures and 5 tabel

Dielectric study of the glass transition: correlation with calorimetric data

The glass transition in amorphous poly(ethylene terephthalate) is studied by thermally stimulated depolarization currents (TSDC) and differential scanning calorimetry (DSC). The ability of TSDC to decompose a distributed relaxation, as the glass transition, into its elementary components is demonstrated. Two polarization techniques, windows polarization (WP) and non-isothermal windows polarization (NIW), are employed to assess the influence of thermal history in the results. The Tool-Narayanaswami-Moynihan (TNM) model has been used to fit the TSDC spectra. The most important contributions to the relaxation comes from modes with non-linearity (x) around 0.7. Activation energies yield by this model are located around 1eV for polarization temperature (Tp) below 50C and they raise up to values higher than 8eV as Tp increases (up to 80C). There are few differences between results obtained with WP and NIW but, nonetheless, these are discussed. The obtained kinetic parameters are tested against DSC results in several conditions. Calculated DSC curves at several cooling and heating rates can reproduce qualitatively experimental DSC results. These results also demonstrate that modelization of the non-equilibrium kinetics involved in TSDC spectroscopy is a useful experimental tool for glass transition studies in polar polymers.Comment: 13 pages, 2 tables, 10 figures; minor change

Effets de l'eutypiose sur des feuilles de Vitis vinifera cv. Cabernet Sauvignon. Etude cytologique

Effects of Eutypa dieback on the leaves of Vitis vinifera cv. Cabernet Sauvignon. Cytological studiesThe fungus Eutypa lata only grows in lignified wood (trunk and arms) and causes at a distance typical symptoms on the leaves of Vitis vinifera cv. Cabernet Sauvignon, a very sensitive variety. For the first time, lesions induced in vivo in leaf cells were examined by transmission electron microscopy. The main alterations of ultrastructure are depending on the level of disease. In the cells of slightly affected leaves, the enlarged chloroplasts show dilated thylakoids with a lowered electron density and sometimes contain very large starch grains. In the severely affected leaves, the cells are completely disorganized, with plasmalemma retraction, chloroplast degradation, cytoplasm lysis and endomembrane breakdown. These results suggest that structural decline of the photosynthetic system can be responsible, at least partly, for the death of Cabernet Sauvignon grapevines

Transitions/relaxations in polyester adhesive/PET system

The correlations between the transitions and the dielectric relaxation processes of the oriented poly(ethylene terephthalate) (PET) pre-impregnated of the polyester thermoplastic adhesive have been investigated by differential scanning calorimetry (DSC) and dynamic dielectric spectroscopy (DDS). The thermoplastic polyester adhesive and the oriented PET films have been studied as reference samples. This study evidences that the adhesive chain segments is responsible for the physical structure evolution in the PET-oriented film. The transitions and dielectric relaxation modes’ evolutions in the glass transition region appear characteristic of the interphase between adhesive and PET film, which is discussed in terms of molecular mobility. The storage at room temperature of the adhesive tape involves the heterogeneity of the physical structure, characterized by glass transition dissociation. Thus, the correlation between the transitions and the dielectric relaxation processes evidences a segregation of the amorphous phases. Therefore, the physical structure and the properties of the material have been linked to the chemical characteristics

The Somatostatin 2A Receptor Is Enriched in Migrating Neurons during Rat and Human Brain Development and Stimulates Migration and Axonal Outgrowth

The neuropeptide somatostatin has been suggested to play an important role during neuronal development in addition to its established modulatory impact on neuroendocrine, motor and cognitive functions in adults. Although six somatostatin G protein-coupled receptors have been discovered, little is known about their distribution and function in the developing mammalian brain. In this study, we have first characterized the developmental expression of the somatostatin receptor sst2A, the subtype found most prominently in the adult rat and human nervous system. In the rat, the sst2A receptor expression appears as early as E12 and is restricted to post-mitotic neuronal populations leaving the ventricular zone. From E12 on, migrating neuronal populations immunopositive for the receptor were observed in numerous developing regions including the cerebral cortex, hippocampus and ganglionic eminences. Intense but transient immunoreactive signals were detected in the deep part of the external granular layer of the cerebellum, the rostral migratory stream and in tyrosine hydroxylase- and serotonin- positive neurons and axons. Activation of the sst2A receptor in vitro in rat cerebellar microexplants and primary hippocampal neurons revealed stimulatory effects on neuronal migration and axonal growth, respectively. In the human cortex, receptor immunoreactivity was located in the preplate at early development stages (8 gestational weeks) and was enriched to the outer part of the germinal zone at later stages. In the cerebellum, the deep part of the external granular layer was strongly immunoreactive at 19 gestational weeks, similar to the finding in rodents. In addition, migrating granule cells in the internal granular layer were also receptor-positive. Together, theses results strongly suggest that the somatostatin sst2A receptor participates in the development and maturation of specific neuronal populations during rat and human brain ontogenesis

Demasculinization of male guppies increases resistance to a common and harmful ectoparasite

Parasites are detrimental to host fitness and therefore should strongly select for host defence mechanisms. Yet, hosts vary considerably in their observed parasite loads. One notable source of inter-individual variation in parasitism is host sex. Such variation could be caused by the immunomodulatory effects of gonadal steroids. Here we assess the influence of gonadal steroids on the ability of guppies (Poecilia reticulata) to defend themselves against a common and deleterious parasite (Gyrodactylus turnbulli). Adult male guppies underwent 31 days of artificial demasculinization with the androgen receptor-antagonist flutamide, or feminization with a combination of flutamide and the synthetic oestrogen 17 β-estradiol, and their parasite loads were compared over time to untreated males and females. Both demasculinized and feminized male guppies had lower G. turnbulli loads than the untreated males and females, but this effect appeared to be mainly the result of demasculinization, with feminization having no additional measurable effect. Furthermore, demasculinized males, feminized males and untreated females all suffered lower Gyrodactylus-induced mortality than untreated males. Together, these results suggest that androgens reduce the ability of guppies to control parasite loads, and modulate resistance to and survival from infection. We discuss the relevance of these findings for understanding constraints on the evolution of resistance in guppies and other vertebrates

Conservatively treated glassy cell carcinoma of the cervix

<p>Abstract</p> <p>Background</p> <p>Very little data about the conservative treatment of early stage glassy cell cervical cancer have been reported.</p> <p>Case presentation</p> <p>A 30-year old patient, nulligravida was admitted to the Gynecologic Oncology Unit of the Catholic University of Campobasso for irregular post-coital vaginal bleeding. The patients was staged as having FIGO stage IB1 (tumor diameter = 2 cm) squamous cervical cancer. After extensive counseling of the patient and her family, laparoscopic pelvic lymphadenectomy and cold knife conization were performed. The final diagnosis was FIGO Stage IB1 glassy cell carcinoma. Currently, after a follow-up of 38 months, she has no evidence of disease.</p> <p>Conclusion</p> <p>We reported a case of early stage glassy cell cancer patient, who was conservatively treated by conization and laparoscopic pelvic lymphadenectomy.</p

Arctic marine phytobenthos of northern Baffin Island

This project was supported by SAMS and NFSD core funding (Oceans 2025 WP 4.5 from the UK Natural Environment Research Council), the European Commission (ASSEMBLE, grant agreement no. 227799), and the TOTAL Foundation (Paris; Project “Macroalgal and oomycete benthic diversity in the Canadian Marine Arctic”). This work also received funding from the MASTS pooling initiative (The Marine Alliance for Science and Technology for Scotland) and their support is gratefully acknowledged. MASTS is funded by the Scottish Funding Council (grant reference HR09011) and contributing institutions. We also would like to thank Laura Grenville-Briggs (KTH, Stockholm) for help with bioinformatics analyses as well as Cindy Grant and Philippe Archambault (University of Quebec, Rimouski) for help with preparing the map of the study area (Fig. 1).Peer reviewedPublisher PD

The first consensus statement on revisional bariatric surgery using a modified Delphi approach

Background: Revisional bariatric surgery (RBS) constitutes a possible solution for patients who experience an inadequate response following bariatric surgery or significant weight regain following an initial satisfactory response. This paper reports results from the first modified Delphi consensus-building exercise on RBS. Methods: We created a committee of 22 recognised opinion-makers with a special interest in RBS. The committee invited 70 RBS experts from 27 countries to vote on 39 statements concerning RBS. An agreement amongst ≥ 70.0% experts was regarded as a consensus. Results: Seventy experts from twenty-seven countries took part. There was a consensus that the decision for RBS should be individualised (100.0%) and multi-disciplinary (92.8%). Experts recommended a preoperative nutritional (95.7%) and psychological evaluation (85.7%), endoscopy (97.1%), and a contrast series (94.3%). Experts agreed that Roux-Y gastric bypass (RYGB) (94.3%), One anastomosis gastric bypass (OAGB) (82.8%), and single anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) (71.4%) were acceptable RBS options after gastric banding (84.3%). OAGB (84.3%), bilio-pancreatic diversion/duodenal switch (BPD/DS) (81.4%), and SADI-S (88.5%) were agreed as consensus RBS options after sleeve gastrectomy. lengthening of bilio-pancreatic limb was the only consensus RBS option after RYGB (94.3%) and OAGB (72.8%). Conclusion: Experts achieved consensus on a number of aspects of RBS. Though expert opinion can only be regarded as low-quality evidence, the findings of this exercise should help improve the outcomes of RBS while we develop robust evidence to inform future practice