Formulation and Optimization of Sustained Release Floating Matrix Tablets of Baclofen

This investigation concerns the development of sustained released floating matrix tablets of Baclofen for improving its bioavailability by prolonging gastric residence time. Floating matrix tablets (FMT) of Baclofen were prepared using 32 optimization designs.Carbopol 934p, HPMC K4M and gas generating agents such as sodium bicarbonate and citric acid were used in formulation. The fabricated tablets were evaluated for their physical characteristics such as hardness, drug content, buoyancy, swelling properties and in vitro release studies in 0.1N HCl. The tablets without gas generating agents and HPMC K4M did not float at all. Tablets with gas generating agents and HPMC K4M and Carbopol 934p floated up to 12 h without complete erosion and showed slower drug release. HPMC K4M and Carbopol 934P maintain the integrity of the FMT and sustaining the drug release. The increase in the concentration of HPMC K4M and Carbopol 934p in FMT from 75 mg to 125 mg and 20 mg to 60mg respectively resulted in decrease in release rate of drug. The possibility of drug polymer interaction was determined by differential scanning calorimetric (DSC) and Fourier transform infrared (FTIR) spectrometer, and confirmed no interaction between drug and polymers. The mechanism of drug release is mainly described by diffusion and swelling mechanism of polymers

Formulation and Optimization of Sustained Release Floating Matrix Tablets of Baclofen

This investigation concerns the development of sustained released floating matrix tablets of Baclofen for improving its bioavailability by prolonging gastric residence time. Floating matrix tablets (FMT) of Baclofen were prepared using 32 optimization designs.Carbopol 934p, HPMC K4M and gas generating agents such as sodium bicarbonate and citric acid were used in formulation. The fabricated tablets were evaluated for their physical characteristics such as hardness, drug content, buoyancy, swelling properties and in vitro release studies in 0.1N HCl. The tablets without gas generating agents and HPMC K4M did not float at all. Tablets with gas generating agents and HPMC K4M and Carbopol 934p floated up to 12 h without complete erosion and showed slower drug release. HPMC K4M and Carbopol 934P maintain the integrity of the FMT and sustaining the drug release. The increase in the concentration of HPMC K4M and Carbopol 934p in FMT from 75 mg to 125 mg and 20 mg to 60mg respectively resulted in decrease in release rate of drug. The possibility of drug polymer interaction was determined by differential scanning calorimetric (DSC) and Fourier transform infrared (FTIR) spectrometer, and confirmed no interaction between drug and polymers. The mechanism of drug release is mainly described by diffusion and swelling mechanism of polymers

COVID-19: New Challenge in 21st Century

COVID-19 pandemic turned into the proven existence-threatening virus in-line with World Health Organization (WHO) has declared a public health emergency of International Concerned and our healthcare system found a challenge to save human civilization. This evaluation gives a brief idea of COVID-19 epidemiology, pathophysiology, treatment, and prevention of COVID-19. Exclusive drugs like Dexamethasone and Remdesivir were found effective to treat the virus was covered in this review article. Pathophysiology of virus in the body of diabetes and cancer patients, there mechanism of action and risk involved in that patients were studied. This review turned to conduct on data found in science direct, various information sources on the internet and different review articles were studied. The major objective is to provide a brief overview of this disease, study infectious virus effect on   human beings proves to be an existence-threat to the world population and brief overview of COVID-19 was covered in this review article. Keywords: SARS-CoV-2, MERS, Vaccine, Dexamethasone, Remdesivir

Clinical Trials: Essential Stage in Development of Drug

This article gives an idea about the clinical trials and way its importance in the development of the vaccine. The different phases which are involved in clinical trials like phase I, phase II, phase III, and phase IV. Each phase role in the development of vaccines and how clinical trials play an important role in the treatment of various diseases. The role of a clinical trial is to help society and the entire medical community by contributing to the research and development of new drugs concerning their safety and efficacy. Keywords: Preclinical trials, phase I trial, phase II trial, phase III trial, phase IV tria