EFFECT OF CONSTANT VOLUME STRUCTURE PARAMETERS ON GRAIN VENTILATION DRYING

ABSTRACT The structural parameters of a grain dryer are directly related to the its energy consumption and quality formation. Therefore, based on the Ergun model, air state parameters and uniformity evaluation method, the effect of changes in the ventilation area on grain airflow resistance, drying energy consumption, drying efficiency and uniformity are theoretically and experimentally studied in this work under the same initial grain weight and air flux. The results show that under the conditions of air temperatures 35℃ and 70℃, the weight of paddy 8.547 kg and the air flux 12.3 m3·h-1, hot air introduced into the drying chamber with cross-sectional areas of S1 and S2 respectively, the ventilation area enlarged by 2.328 times, the grain airflow resistance decreased by 7.17 and 6.99 times. Enlarging the ventilation area effectively improved the drying rate of paddy, especially at 70℃, while the unit energy consumption was the opposite. It also accelerated the moving speed of the saturated humidity line in the drying layer and improved the drying uniformity of the paddy. These experimental results are in agreement with the theoretical analysis, which provides a reference for the design of grain drying equipment and technology

Study on the efficacy, safety, and biomarkers of nusinersen in type II and III spinal muscular atrophy in children

Introduction/aimsThe time span for the approval of nusinersen to treat SMA remains short. Most studies on the efficacy and safety of this drug within clinical trials, are lacking real-world research data. This study is based on real-world studies of SMA patients in children with type II and III SMA and is committed to objectively evaluating the effectiveness and safety of this drug.MethodsA retrospective analysis was conducted on the clinical data of 18 children with type II and III SMA from January 2022 to June 2023. The motor function assessment scale, SMN protein, platelet, liver and kidney function, and other laboratory indicators of all patients before and after treatment were collected for statistical analysis.ResultsAfter load dose treatment (after 64 days of treatment), compared with baseline, the Revised Upper Limb Module (RULM) of SMA patients showed significant improvement (improvement rate: 44%), confirming the short-term effectiveness of the drug. The increase in cerebrospinal fluid SMN protein was greater in patients with significant improvement in motor function than in patients without improvement in motor function. Compared with baseline, there was no significant increase in AST and ALT levels in SMA patients, indicating that the drug had almost no effect on the liver. After each treatment, thrombocytopenia and partial urinary protein positivity may occur, but it could recover before the next treatment. This indicates that nusinersen is potentially harmful to platelet and renal function, although the effect is weak and reversible.DiscussionNusinersen has shown good efficacy and overall safety, but platelets and urinary protein are still indicators that require long-term monitoring. The increase in cerebrospinal fluid SMN protein was greater in patients with significant improvement in motor function than in patients without improvement in motor function

Non-heat related impacts of climate change on working populations

Environmental and social changes associated with climate change are likely to have impacts on the well-being, health, and productivity of many working populations across the globe. The ramifications of climate change for working populations are not restricted to increases in heat exposure. Other significant risks to worker health (including physical hazards from extreme weather events, infectious diseases, under-nutrition, and mental stresses) may be amplified by future climate change, and these may have substantial impacts at all scales of economic activity. Some of these risks are difficult to quantify, but pose a substantial threat to the viability and sustainability of some working populations. These impacts may occur in both developed and developing countries, although the latter category is likely to bear the heaviest burden

The 2021 China report of the Lancet Countdown on health and climate change: seizing the window of opportunity

China, with its growing population and economic development, faces increasing risks to health from climate change, but also opportunities to address these risks and protect health for generations to come. Without a timely and adequate response, climate change will impact lives and livelihoods at an accelerated rate. In 2020, the Lancet Countdown Regional Centre in Asia, led by Tsinghua University, built on the work of the global Lancet Countdown and began its assessment of the health profile of climate change in China with the aim of triggering rapid and health-responsive actions. This 2021 report is the first annual update, presenting 25 indicators within five domains: climate change impacts, exposures, and vulnerability; adaptation, planning, and resilience for health; mitigation actions and health co-benefits; economics and finance; and public and political engagement. The report represents the contributions of 88 experts from 25 leading institutions in, and outside of, China. From 2020 to 2021, five new indicators have been added and methods have been improved for many indicators. Where possible, the indicator results are presented at national and provincial levels to facilitate local understanding and policy making. In a year marked by COVID-19, this report also endeavours to reflect on China's pathway for a green recovery, ensuring it aligns with the carbon neutrality goal, for the health of the current and future generations

Seizing the window of opportunity to mitigate the impact of climate change on the health of Chinese residents

The health threats posed by climate change in China are increasing rapidly. Each province faces different health risks. Without a timely and adequate response, climate change will impact lives and livelihoods at an accelerated rate and even prevent the achievement of the Healthy and Beautiful China initiatives. The 2021 China Report of the Lancet Countdown on Health and Climate Change is the first annual update of China’s Report of the Lancet Countdown. It comprehensively assesses the impact of climate change on the health of Chinese households and the measures China has taken. Invited by the Lancet committee, Tsinghua University led the writing of the report and cooperated with 25 relevant institutions in and outside of China. The report includes 25 indicators within five major areas (climate change impacts, exposures, and vulnerability; adaptation, planning, and resilience for health; mitigation actions and health co-benefits; economics and finance; and public and political engagement) and a policy brief. This 2021 China policy brief contains the most urgent and relevant indicators focusing on provincial data: The increasing health risks of climate change in China; mixed progress in responding to climate change. In 2020, the heatwave exposures per person in China increased by 4.51 d compared with the 1986–2005 average, resulting in an estimated 92% increase in heatwave-related deaths. The resulting economic cost of the estimated 14500 heatwave-related deaths in 2020 is US$176 million. Increased temperatures also caused a potential 31.5 billion h in lost work time in 2020, which is equivalent to 1.3% of the work hours of the total national workforce, with resulting economic losses estimated at 1.4% of China’s annual gross domestic product. For adaptation efforts, there has been steady progress in local adaptation planning and assessment in 2020, urban green space growth in 2020, and health emergency management in 2019. 12 of 30 provinces reported that they have completed, or were developing, provincial health adaptation plans. Urban green space, which is an important heat adaptation measure, has increased in 18 of 31 provinces in the past decade, and the capacity of China’s health emergency management increased in almost all provinces from 2018 to 2019. As a result of China’s persistent efforts to clean its energy structure and control air pollution, the premature deaths due to exposure to ambient particulate matter of 2.5 μm or less (PM2.5) and the resulting costs continue to decline. However, 98% of China’s cities still have annual average PM2.5 concentrations that are more than the WHO guideline standard of 10 μg/m3. It provides policymakers and the public with up-to-date information on China’s response to climate change and improvements in health outcomes and makes the following policy recommendations. (1) Promote systematic thinking in the related departments and strengthen multi-departmental cooperation. Sectors related to climate and development in China should incorporate health perspectives into their policymaking and actions, demonstrating WHO’s and President Xi Jinping’s so-called health-in-all-policies principle. (2) Include clear goals and timelines for climate-related health impact assessments and health adaptation plans at both the national and the regional levels in the National Climate Change Adaptation Strategy for 2035. (3) Strengthen China’s climate mitigation actions and ensure that health is included in China’s pathway to carbon neutrality. By promoting investments in zero-carbon technologies and reducing fossil fuel subsidies, the current rebounding trend in carbon emissions will be reversed and lead to a healthy, low-carbon future. (4) Increase awareness of the linkages between climate change and health at all levels. Health professionals, the academic community, and traditional and new media should raise the awareness of the public and policymakers on the important linkages between climate change and health.</p

The 2022 China report of the Lancet Countdown on health and climate change: leveraging climate actions for healthy ageing

A health-friendly, climate resilient, and carbon-neutral pathway would deliver major benefits to people's health and wellbeing in China, especially for older populations, while simultaneously promoting high-quality development in the long run. This report is the third China Lancet Countdown report, led by the Lancet Countdown Regional Centre based in Tsinghua University. With the contributions of 73 experts from 23 leading institutions, both within China and globally, this report tracks progress through 27 indicators in the following five domains: (1) climate change impacts, exposure, and vulnerability; (2) adaptation, planning, and resilience for health; (3) mitigation actions and health co-benefits; (4) economics and finance; and (5) public and political engagement. From 2021 to 2022, two new indicators have been added, and methods have been improved for many indicators. Specifically, one of the new indicators measures how heat affects the hours that are safe for outdoor exercise, an indicator of particular relevance given the boom in national sports triggered by the summer and winter Olympics. Findings in this report, which coincide with the UN Framework Convention on Climate Change 27th Conference of the Parties (COP27) hosted in Egypt (where much attention is being focused on adaptation for clinically vulnerable populations), expose the urgency for accelerated adaptation and mitigation efforts to minimise the health impacts of the increasing climate change hazards in China

Leveraging climate actions for healthy ageing

As China’s population ages rapidly, the health risks associated with a changing climate are becoming more threatening. The 2022 China report of the Lancet Countdown, led by Tsinghua University with the contributions of 73 experts from 23 leading global institutions, tracks progress in climate change and health in China through 27 indicators across five domains: (1) Climate change impacts, exposure, and vulnerability; (2) adaptation, planning, and resilience for health; (3) mitigation actions and health co-benefits; (4) economics and finance; and (5) public and political engagement. This report is the third China Lancet Countdown report, paying particular attention to the impacts on the elderly and highlighting the urgency of taking action. We selected the most urgent and relevant indicators to complete a policy brief that provides a better understanding of recent progress on climate change and health in China. We found heat-related health impacts increased from 2020 to 2021, increasing heat-related mortality, reducing labour capacity, and undermining the capacity to partake in physical activity due to rising temperature. In addition, exposure to wildfire, extreme drought, and extreme rainfall also increased in different regions across China. In 2021, compared with the 1986–2005 average, people in China had an average of 7.85 more heatwave days (which led to an extra 13185 heatwave-related deaths), and a loss of 0.67 more hours of safe outdoor physical exercise per day. The rising temperature also caused the annual average exposure to wildfire to increase by 60.0% between 2017–2021 compared with the 2001–2005 average. Meanwhile, the engagement on health and climate issues from individuals, scholars, and public sectors continues to grow rapidly. From 2020 to 2021, the number of climate-related articles and documents on the official websites of four Chinese Government departments grew by 1.83 times, and the number of climate-and-health-related articles and documents grew by 3.7 times. However, older populations received marginal attention on this issue in media coverage, although they are more vulnerable to the health threats of climate change than younger populations. In most provinces, people aged 65 years and older are facing higher health risks of climate change than the general population. In addition, we found that the inputs and attention to adaptation are still insufficient compared with the increasing health risks posed by climate change. Based on the findings, the following recommendations are made to protect climate change-related health risks: (1) Increasing adaptation across governmental departments and accelerating investment in climate resilience. Adaptation across governmental departments and investment in climate resilience must be substantially increased to protect the health of Chinese populations. (2) Developing a stand-alone Health National Climate Adaptation Plan. Leaders must strengthen the response of local efforts to national plans, for example, by establishing a nationwide heat and cold and health early warning system with regional characteristics. (3) Prioritise climate change in health policies, with a focus on the wellbeing of vulnerable populations. Leaders should include climate change health impact prevention and treatment as one of the key responsibilities of the new National Bureau of Disease Control and Prevention. (4) Accelerating coal reduction and integrating health considerations into China’s pathway to carbon neutrality. Leaders must strictly control the capacity of coal-fired power generation and accelerate the pace of coal reduction (especially in the household sector). (5) Promoting renewable energy generation and consumption by redirecting fossil fuel subsidies to China’s low-carbon economy. Leaders should keep encouraging renewable energy generation and consumption

The 2021 China report of the Lancet Countdown on health and climate change: seizing the window of opportunity

China, with its growing population and economic development, faces increasing risks to health from climate change, but also opportunities to address these risks and protect health for generations to come. Without a timely and adequate response, climate change will impact lives and livelihoods at an accelerated rate. In 2020, the Lancet Countdown Regional Centre in Asia, led by Tsinghua University, built on the work of the global Lancet Countdown and began its assessment of the health profile of climate change in China with the aim of triggering rapid and health-responsive actions. This 2021 report is the first annual update, presenting 25 indicators within five domains: climate change impacts, exposures, and vulnerability; adaptation, planning, and resilience for health; mitigation actions and health co-benefits; economics and finance; and public and political engagement. The report represents the contributions of 88 experts from 25 leading institutions in, and outside of, China. From 2020 to 2021, five new indicators have been added and methods have been improved for many indicators. Where possible, the indicator results are presented at national and provincial levels to facilitate local understanding and policy making. In a year marked by COVID-19, this report also endeavours to reflect on China's pathway for a green recovery, ensuring it aligns with the carbon neutrality goal, for the health of the current and future generations