In vitro susceptibility of 120 strains of Neisseria gonorrhoeae isolated in Kyrghyzstan.

BACKGROUND: The World Health Organization has established a worldwide program for gonococcal antimicrobial surveillance, but so far no data on gonococcal susceptibility in Central Asia are available. GOAL: The need for biological data on the susceptibility of Neisseria gonorrhoeae in Kyrghyzstan, to enable adaptation of the national treatment protocol for gonococcal infections, led Médecins Sans Frontières and Epicentre to conduct a survey in collaboration with the Alfred Fournier Institute in Paris and the health authorities in Bishkek. STUDY DESIGN: In vitro susceptibility of N gonorrhoeae strains was determined with use of the reference agar-plate dilution technique. RESULTS: Results for 11 antibiotics tested on 120 strains of gonococci showed a low proportion (11.7%) of penicillinase-producing N gonorrhoeae and high proportions of intermediate or resistant strains to the majority of the antibiotics tested, including fluoroquinolones (>or=25% of strains resistant). All the strains were susceptible to spectinomycin, and only two strains had decreased susceptibility to cefixime. CONCLUSION: The therapeutic choices available in Kyrghyzstan appear to be limited to cephalosporins and spectinomycin

Metabolic cardioprotection: new concepts in implementation of cardioprotective effects of meldonium

Recent studies confirm the need to find means to correct ischemic / reperfusion injury due to the hemodynamic medicine, which are already known do not have the proper cardioprotective effects. Key issue is the possibility of drug effects on the mitochondria of cardiomyocytes that controls the aerobic metabolism and maintenance of ATP admission into cardiomyocyte

Social and psychological features of inter-cultural adaptation of Russian students in different universities

Modern globalisation processes, the rapid entry of Russia into the world community, have given more opportunities to interact with various ethnic groups ranging from short-term tourist and business contacts to complex processes of migration and emigration. Migrants and visitors have different goals for staying in a new country, meanwhile the researchers note a lot in common within the adaptation processes of both groups. In particular, tension, stresses and experience of cultural shock during adaptation are observed. Therefore, it is necessary to conduct psychological studies not only of migrants who come for a long time to a new country, but also of visitors, i.e., interns, students who come to study in foreign universitie

Spectral multiplicity for powers of weakly mixing automorphisms

We study the behavior of maximal multiplicities $mm (R^n)$ for the powers of a weakly mixing automorphism $R$. For some special infinite set $A$ we show the existence of a weakly mixing rank-one automorphism $R$ such that $mm (R^n)=n$ and $mm(R^{n+1}) =1$ for all $n\in A$. Moreover, the cardinality $cardm(R^n)$ of the set of spectral multiplicities for $R^n$ is not bounded. We have $cardm(R^{n+1})=1$ and $cardm(R^n)=2^{m(n)}$, $m(n)\to\infty$, $n\in A$. We also construct another weakly mixing automorphism $R$ with the following properties: $mm(R^{n}) =n$ for $n=1,2,3,..., 2009, 2010$ but $mm(T^{2011}) =1$, all powers $(R^{n})$ have homogeneous spectrum, and the set of limit points of the sequence $\{\frac{mm (R^n)}{n} : n\in \N \}$ is infinite

Experimental approaches to the assessment of potential cardioprotective means with doxorubicin-associated cardiomyopathy

Development of methodological approaches for evaluation of cardioprotective activity of drugs in doxorubicin cardiomyopath

Preparation de formamide de la benzophenone oxime et les O-derives

Бензгидрилмочевины являются биологически активными соединениями, проявляющими выраженную противосудорожную активность, а субстраты в синтезе бензгидрилмочевин -бензгидриламины. Поэтому целью нашей работы была разработка удобного и экономически выгодного способа получения бензгидриламинов.Первым этапом работы было получение оксимабензофенона, который в дальнейшем восстанавливался до бензгидриламина. Таким образом,нами был найден эффективный метод восстановления оксимабензофенона и его О-производных до соответствующего формамида., который, как известно при гидролизе образует бензгидриламин

Physical properties of thermoelectric zinc antimonide using first-principles calculations

We report first principles calculations of the structural, electronic, elastic and vibrational properties of the semiconducting orthorhombic ZnSb compound. We study also the intrinsic point defects in order to eventually improve the thermoelectric properties of this already very promising thermoelectric material. Concerning the electronic properties, in addition to the band structure, we show that the Zn (Sb) crystallographically equivalent atoms are not exactly equivalent from the electronic point of view. Lattice dynamics, elastic and thermodynamic properties are found to be in good agreement with experiments and they confirm the non equivalency of the zinc and antimony atoms from the vibrational point of view. The calculated elastic properties show a relatively weak anisotropy and the hardest direction is the y direction. We observe the presence of low energy modes involving both Zn and Sb atoms at about 5-6 meV, similarly to what has been found in Zn4Sb3 and we suggest that the interactions of these modes with acoustic phonons could explain the relatively low thermal conductivity of ZnSb. Zinc vacancies are the most stable defects and this explains the intrinsic p-type conductivity of ZnSb.Comment: 33 pages, 8 figure

Effect of multipotent mesenchymal stromal cells secretome on imiquimod-induced psoriasis in rats

Multipotent mesenchymal stromal cells secretome contains a range of anti-inflammatory factors and can be used for the treatment of psoriasi