Educators’ Perceptions of Middle Level Education in a State without a Middle Level Teacher Credential

The Association for Middle Level Education (AMLE) presents a framework of middle level education and defines five essential attributes and 18 characteristics of successful middle schools (Bishop & Harrison, 2021). Young adolescents’ unique cognitive, moral, socio-emotional, and identity development is at the center of this framework. Several empirical studies suggest that middle school teachers with specialized preparation performed better in many key areas than their counterparts with elementary or secondary licensure (Mertens et al., 2005; Ochanji et al., 2016). Despite researchers’ calls for specialized preparation of middle grades teachers. California does not offer a middle level teacher credential. The purpose of this exploratory survey study was to investigate the current state of middle level education in California

Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity

The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity. The Boolean features selected by these logistic models were combined into an Integrated PolyGenic Score that offers a synthetic and interpretable index for describing the contribution of host genetics in COVID-19 severity, as demonstrated through testing in several independent cohorts. Selected features belong to ultra-rare, rare, low-frequency, and common variants, including those in linkage disequilibrium with known GWAS loci. Noteworthily, around one quarter of the selected genes are sex-specific. Pathway analysis of the selected genes associated with COVID-19 severity reflected the multi-organ nature of the disease. The proposed model might provide useful information for developing diagnostics and therapeutics, while also being able to guide bedside disease management. © 2021, The Author(s)

Policy Changes

Objective: Obesity is a significant health concern in the United States. In 2012, more than one third of all U.S. children and adolescents were overweight or obese. Causes of obesity are complex and include behavioral, social, biological and environmental factors. Ignite is a five year, tri-state (Ohio, South Dakota and Kansas), and quasi-experimental project, including one control and one intervention community from each state. Using the community-based participatory research (CBPR) process each intervention community will create and implement nutrition and physical activity programs addressing overweight and obesity among 6–8th grade youth. The objective of this paper is to report the policy changes supporting healthful behaviors that have been implemented due to Ignite