4 research outputs found
Dietary Reference Intakes for vitamin D: justification for a review of the 1997 values123
Recent Institute of Medicine (IOM) reviews of the process for deriving Dietary
Reference Intakes (DRIs) suggest that determining the need for a new nutrient
review should be evaluated against criteria set a priori. After selecting the
criterion of significant new and relevant research, a working group of US and
Canadian government scientists used results from a systematic review and 2
conferences on vitamin D and health to evaluate whether significant new and
relevant scientific evidence had become available since the 1997 IOM publication
of the DRIs for vitamin D. This working group concluded that there appears to be
new research meeting the criteria for 4 key DRI questions. The new research is
of larger quantity and quality for the elderly than for other groups, but
overall 1) adds to the bone-related and status evidence
available to the 1997 DRI Committee for several of the life-stage groups,
2) identifies new outcomes with respect to risk of falls
and performance measures in the elderly and potential adverse effects, and
3) provides additional information on dose-response
relations between intakes and circulating 25-hydroxyvitamin D concentrations and
between 25-hydroxyvitamin D concentrations and several health outcomes (ie,
bone-related outcomes for all ages and risk of falls and performance measures in
older adults). Members of the working group concluded that significant new and
relevant research was available for reviewing the existing DRIs for vitamin D
while leaving the decision of whether the new research will result in changes to
the current DRIs to a future IOM-convened DRI committee