Real World Estimate of Vaccination Protection in Individuals Hospitalized for COVID-19

Whether vaccination confers a protective effect against progression after hospital admission for COVID-19 remains to be elucidated. Observational study including all the patients admitted to San Paolo Hospital in Milan for COVID-19 in 2021. Previous vaccination was categorized as: none, one dose, full vaccination (two or three doses >14 days before symptoms onset). Data were collected at hospital admission, including demographic and clinical variables, age-unadjusted Charlson Comorbidity index (CCI). The highest intensity of ventilation during hospitalization was registered. The endpoints were in-hospital death (primary) and mechanical ventilation/death (secondary). Survival analysis was conducted by means of Kaplan-Meier curves and Cox regression models. Effect measure modification by age was formally tested. We included 956 patients: 151 (16%) fully vaccinated (18 also third dose), 62 (7%) one dose vaccinated, 743 (78%) unvaccinated. People fully vaccinated were older and suffering from more comorbidities than unvaccinated. By 28 days, the risk of death was of 35.9% (95%CI: 30.1–41.7) in unvaccinated, 41.5% (24.5–58.5) in one dose and 28.4% (18.2–38.5) in fully vaccinated (p = 0.63). After controlling for age, ethnicity, CCI and month of admission, fully vaccinated participants showed a risk reduction of 50% for both in-hospital death, AHR 0.50 (95%CI: 0.30–0.84) and for mechanical ventilation or death, AHR 0.49 (95%CI: 0.35–0.69) compared to unvaccinated, regardless of age (interaction p > 0.56). Fully vaccinated individuals in whom vaccine failed to keep them out of hospital, appeared to be protected against critical disease or death when compared to non-vaccinated. These data support universal COVID-19 vaccination

De Novo and Rare Inherited Copy-Number Variations in the Hemiplegic Form of Cerebral Palsy

PurposeHemiplegia is a subtype of cerebral palsy (CP) in which one side of the body is affected. Our earlier study of unselected children with CP demonstrated de novo and clinically relevant rare inherited genomic copy-number variations (CNVs) in 9.6% of participants. Here, we examined the prevalence and types of CNVs specifically in hemiplegic CP.MethodsWe genotyped 97 unrelated probands with hemiplegic CP and their parents. We compared their CNVs to those of 10,851 population controls, in order to identify rare CNVs

A new Scattering and Neutrino Detector at the LHC (SND@LHC)

The Scattering and Neutrino Detector (SND@LHC) is a compact and stand-alone experiment to perform measurements with neutrinos produced at the LHC in a hitherto unexplored pseudo-rapidity region of $7.2\, <\, \eta \,<\, 8.4$, complementary to all the other experiments at the LHC. The experiment is located 480 m downstream of IP1 in the unused TI18 tunnel. The detector is composed of a hybrid system based on a 800 kg target mass of tungsten plates, interleaved with emulsion and electronic trackers, followed downstream by a calorimeter and a muon system. The configuration allows efficiently distinguishing between all three neutrino flavours, opening a unique opportunity to probe physics of heavy flavour production at the LHC in the region that is not accessible to ATLAS, CMS and LHCb. This region is of particular interest also for future circular colliders and for predictions of very high-energy atmospheric neutrinos. The physics programme includes studies of charm production, and lepton universality tests in the neutral sector. The detector concept is also well suited to searching for Feebly Interacting Particles via signatures of scattering in the detector target. The first phase aims at operating the detector throughout LHC Run 3 to collect a total of 250 \mbox{fb}^{-1}. We report the results from the data taken in 2022, namely the measurement of the muon flux at TI18 and the observation of muon neutrino interactions

Power-Efficient Design of Large-Aperture Magnets for High-Energy Physics

Anovel and sustainability-oriented approach to the design of large-aperture iron-dominated magnets is proposed, focusing on its application to charged particle momentum detection in highenergy experimental physics. As compared to classical design techniques, a broader number of goals and constraints is taken into account, considering jointly the detection performance, the minimization of both the electrical power and magnet size, and the electromagnetic efficiency. A case study is considered for the detector magnet of a specific experiment, where the optimal design is pursued with semi-analytical tools, duly introducing the main quantities’ scaling laws in analytical form and successively validating the results with 3D numerical tools. A solution at higher energy efficiency is obtained, as compared to a more traditional design point of view. The proposed methodology can be fruitfully employed also in the design of magnets with a reduced ecological footprint in a number of other industrial and medical applications

Aby Warburg, Il metodo della scienza della cultura [1927]

The contribution presents a new German edition with an Italian translation by Seminario Mnemosyne of the draft by Aby Warburg [WIA 99.5=113.6 and 113.4.1] devoted to the research method for the science of culture, and used for the conclusive meeting of the Winter Seminar organized in 1927-1929 by the Kulturwissenschaftliche Bibliothek Warburg