SNPs showing strong evidence for functional importance based on bioinformatics.

<p>SNPs showing strong evidence for functional importance based on bioinformatics.</p

Comparison of <i>P</i>-values for GWAS-identified variants (index SNPs) vs. variants with the smallest <i>P</i>-values (top SNPs) in 31 regions.

<p>The height of each bar reflects the–log10 <i>P</i>-value of each SNP in our study population. A grey bar indicates the index SNP, and a black bar indicates the top SNP.</p

Association results for variants showing the smallest <i>P</i>-values (top SNPs) in 31 regions surrounding previous GWAS-identified variants (index SNPs).

<p>Association results for variants showing the smallest <i>P</i>-values (top SNPs) in 31 regions surrounding previous GWAS-identified variants (index SNPs).</p

Results for selected top interactions among top marginal loci with p-value less than 5×10⁻⁵ in Phase I studies.

<p>P_het is the heterogeneity p-value.</p

Performance of nested subsets of AIMs.

<p>Performance of nested subsets of AIMs.</p

Time since admixture for Mestizo and African descendent populations.

<p>Time since admixture for Mestizo and African descendent populations.</p

Ancestry of Latin American populations.

<p>Ancestries are given in median and 25^th:75^th percentiles.</p

Algorithm for selecting AIMs.

<p>Algorithm for selecting AIMs.</p

Characteristics of the AIMs panel.

<p>Characteristics of the AIMs panel.</p

Regional interaction association plot for interacting region 5q21 with known CRC locus rs10795668.

<p>The left y-axis shows the -log10 of the meta-analysis interaction p value. The right y-axis shows the recombination rate. Each dot on the plot represents the result for one SNP. The diamond dot represents SNP rs367615 and the round dots represent other SNPs. Difference colors of SNPs indicate different LD strength between the corresponding SNP and rs367615, measured by r². The bottom of the figure shows the genes in the plotted region.</p