Advanced Visual Analytics Interfaces for Adverse Drug Event Detection

Adverse reactions to drugs are a major public health care issue. Currently, the Food and Drug Administration (FDA) publishes quarterly reports that typically contain on the order of 200,000 adverse incidents. In such numerous incidents, low frequency events that are clinically highly significant often remain undetected. In this paper, we introduce a visual analytics system to solve this problem using (1) high scalable interfaces for analyzing correlations between a number of complex variables (e.g., drug and reaction); (2) enhanced statistical computations and interactive relevance filters to quickly identify significant events including those with a low frequency; and (3) a tight integration of expert knowledge for detecting and validating adverse drug events. We applied these techniques to the FDA Adverse Event Reporting System and were able to identify important adverse drug events, such as the known association of the drug Avandia with myocardial infarction and Seroquel with diabetes mellitus, as well as low frequency events such as the association of Boniva with femur fracture. In our evaluation, we found over 90% of the adverse drug events that were published in the Institute for Safe Medication Practices (ISMP) reports from 2009 to 2012. In addition, our domain expert was able to identify some previously unknown adverse drug events

Fractional Genomic Alteration Detected by Array-Based

Purpose: Although liver resection is the primary curative therapy for patients with colorectal hepatic metastases, most patients have a recurrence. Identification of molecular markers that predict patients at highest risk for recurrence may help to target further therapy