56,859 research outputs found
Convexity of the effective action from functional flows
We show that convexity of the effective action follows from its functional
flow equation. Our analysis is based on a new, spectral representation. The
results are relevant for the study of physical instabilities. We also derive
constraints for convexity-preserving regulators within general truncation
schemes including proper-time flows, and bounds for infrared anomalous
dimensions of propagators.Comment: 4 pages, 3 figure
Signatures of gravitational fixed points at the LHC
We study quantum-gravitational signatures at the CERN Large Hadron Collider (LHC) in the context of theories with extra spatial dimensions and a low fundamental Planck scale in the TeV range. Implications of a gravitational fixed point at high energies are worked out using Wilson¿s renormalization group. We find that relevant cross sections involving virtual gravitons become finite. Based on gravitational lepton pair production we conclude that the LHC is sensitive to a fundamental Planck scale of up to 6 TeV
The genomics of neonatal abstinence syndrome
Significant variability has been observed in the development and severity of neonatal abstinence syndrome (NAS) among neonates exposed to prenatal opioids. Since maternal opioid dose does not appear to correlate directly with neonatal outcome, maternal, placental, and fetal genomic variants may play important roles in NAS. Previous studies in small cohorts have demonstrated associations of variants in maternal and infant genes that encode the μ-opioid receptor (OPRM1), catechol-O-methyltransferase (COMT), and prepronociceptin (PNOC) with a shorter length of hospital stay and less need for treatment in neonates exposed to opioids in utero. Consistently falling genomic sequencing costs and computational approaches to predict variant function will permit unbiased discovery of genomic variants and gene pathways associated with differences in maternal and fetal opioid pharmacokinetics and pharmacodynamics and with placental opioid transport and metabolism. Discovery of pathogenic variants should permit better delineation of the risk of developing more severe forms of NAS. This review provides a summary of the current role of genomic factors in the development of NAS and suggests strategies for further genomic discovery
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