Hydrodynamics of a periodically wind‑forced small and narrow stratified basin: a large‑eddy simulation experiment

We report novel results of a numerical experiment designed for examining the basin-scale hydrodynamics that control the mass, momentum, and energy distribution in a daily wind-forced, small thermally-stratified basin. For this purpose, the 3-D Boussinesq equations of motion were numerically solved using large-eddy simulation (LES) in a simplified (trapezoidal) stratified basin to compute the flow driven by a periodic wind shear stress working at the free surface along the principal axis. The domain and flow parameters of the LES experiment were chosen based on the conditions observed during summer in Lake Alpnach, Switzerland. We examine the diurnal circulation once the flow becomes quasi-periodic. First, the LES results show good agreement with available observations of internal seiching, boundary layer currents, vertical distribution of kinetic energy dissipation and effective diffusivity. Second, we investigated the wind-driven baroclinic cross-shore exchange. Results reveal that a near-resonant regime, arising from the coupling of the periodic wind-forcing (T=24 h) and the V2H1 basin-scale internal seiche (TV2H1≈24 h), leads to an active cross-shore circulation that can fully renew near-bottom waters at diurnal scale. Finally, we estimated the bulk mixing efficiency, Γ, of relevant zones, finding high spatial variability both for the turbulence intensity and the rate of mixing (10−3≤Γ≤10−1). In particular, significant temporal variability along the slopes of the basin was controlled by the periodic along-slope currents resulting from the V2H1 internal seiche

Application of a 3-D CFD model to investigate flood-related engineering problems

The paper discusses the application of a fully 3-D, non-hydrostatic, RANS model with deformable free-surface capabilities to several main types of flood-related engineering problems. The model is found to accurately simulate the dam break flow developing in a 900 open channel bend for which detailed validation data from a laboratory experiment are available. First practical application deals with mitigation of flooding extent via implementation of flood protection structures such as floodwalls. Numerical results show that the floodwalls effectively protect the critical regions situated in the vicinity of the river and the reduction of the flooded area with respect to the case when floodwalls are not present is about the same at high-flow conditions and at low-flow conditions. The second application deals with prediction of flow structure around a location containing a bridge whose deck becomes submerged as the flood wave passes the bridge location. The final application considers the effects of a sudden dam break failure for a dam situated upstream of the Iowa City, USA

Application of a 3-D CFD model to investigate flood-related engineering problems

The paper discusses the application of a fully 3-D, non-hydrostatic, RANS model with deformable free-surface capabilities to several main types of flood-related engineering problems. The model is found to accurately simulate the dam break flow developing in a 900 open channel bend for which detailed validation data from a laboratory experiment are available. First practical application deals with mitigation of flooding extent via implementation of flood protection structures such as floodwalls. Numerical results show that the floodwalls effectively protect the critical regions situated in the vicinity of the river and the reduction of the flooded area with respect to the case when floodwalls are not present is about the same at high-flow conditions and at low-flow conditions. The second application deals with prediction of flow structure around a location containing a bridge whose deck becomes submerged as the flood wave passes the bridge location. The final application considers the effects of a sudden dam break failure for a dam situated upstream of the Iowa City, USA

Ezetimibe added to statin therapy after acute coronary syndromes

BACKGROUND: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known. METHODS: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization ( 6530 days after randomization), or nonfatal stroke. The median follow-up was 6 years. RESULTS: The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (P<0.001). The Kaplan-Meier event rate for the primary end point at 7 years was 32.7% in the simvastatin-ezetimibe group, as compared with 34.7% in the simvastatin-monotherapy group (absolute risk difference, 2.0 percentage points; hazard ratio, 0.936; 95% confidence interval, 0.89 to 0.99; P = 0.016). Rates of pre-specified muscle, gallbladder, and hepatic adverse effects and cancer were similar in the two groups. CONCLUSIONS: When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit