Medical Institutional Repositories in a Changing Scholarly Communication Landscape

An institutional repository (IR) is an online digital archive that organizes, preserves, and provides access to the educational, scholarly, and research output of an institution. Medical libraries began establishing IRs more than a decade ago and these repositories have become an important component of scholarly communication outreach. In an article in the 2014 Against the Grain health and biomedical sciences special issue, Palmer described institutional repository services provided by health sciences libraries, and the barriers and challenges to providing those services. What has changed since 2014? What is the current landscape for repositories in medical and health sciences libraries

Comparing and Contrasting Medical Institutional Repositories with Other Academic IRs: Results of Two Research Studies

This poster presents findings from two research studies about institutional repositories (IRs): one survey to members of the Association of Academic Health Sciences Libraries, and the other an open survey with primary responses from academic libraries in North America. The poster compares and contrasts several findings, including: Are academic medical institutional repositories utilizing different software platforms than other academic IRs? Are academic medical IRs staffed differently than other academic IRs? In this complex scholarly communication environment, are IR managers considering plans to migrate to new platforms? This poster explores findings from the two surveys to help capture a current snapshot of the repository landscape. This will be a “poster conversation” where we will engage attendees about the repositories at their own institutions and give them an opportunity for meaningful discussion. Presented as an interactive iPosterSessions poster at the Association of College and Research (ACRL) 2019 Conference, Cleveland, OH, April 11, 2019

Factors Influencing Nest Attendance and Time-activity Budgets of Peregrine Falcons in Interior Alaska

An essential prerequisite to examining the impacts of anthropogenic disturbance on avian nesting activities is understanding the intrinsic and extrinsic factors that influence the birds' allocation of time to breeding behaviors. We examined factors influencing nest attendance and time-activity budgets of peregrine falcons (Falco peregrinus anatum) breeding along the Tanana River in Alaska in 1995, 1996, and 1997. First, as is typical of most bird species with nidicolous young and biparental care, females attended the nest more than males and, as the nesting cycle progressed, female attendance decreased to levels similar to those of males. Second, nest area attendance followed a circadian rhythm; parents attended the nest area less during early morning and late evening, which are prime hunting periods, than during late morning. Finally, although females typically performed most of the incubating, the division of labor between males and females during incubation differed among pairs. Higher attendance in the nest area by females during incubation appeared to be associated with more young fledged among successful pairs.Une condition indispensable pour examiner les retombées de la perturbation anthropique sur la nidification aviaire est reproducteurs. On a étudié les facteurs qui ont influencé la présence au nid et les budgets temps-activités des faucons pèlerins (Falco peregrinus anatum) nichant le long de la rivière Tanana en Alaska en 1995, 1996 et 1997. Tout d'abord, comme on doit s'y attendre de la plupart des espèces aviaires dont les petits sont nidicoles et où les soins sont biparentaux, les femelles étaient présentes au nid plus que les mâles et, à mesure que le cycle de nidification avançait, la présence des femelles diminuait à des niveaux semblables à ceux de la présence des mâles. Deuxièmement, la présence aux environs du nid suivait un rythme circadien, les parents passant moins de temps près du nid au début de la matinée et en fin de soirée - temps forts de la chasse - qu'en fin de et femelles durant l'incubation différait selon les paires. Durant l'incubation, la présence plus affirmée des femelles dans la zone du nid semblait être associée à un nombre supérieur de petits qui prenaient leur envol chez les paires qui avaient réussi à se reproduire

If We Knew Then What We Know Now: Lessons Learned in Managing Two Academic Health Science Institutional Repositories

Poster presented at ACRL annual conference in Portland Oregon. Time: 2:00 PM - 3:00 PM Location: Exhibit Hall - Poster 2

Taking the Temperature of Health Sciences IRs: A Survey and Analysis of Medical Schools’ Institutional Repositories

Background: The proposal authors are health sciences librarians from three different medical schools who are conducting a survey of institutional repositories (IRs) in medical libraries and academic health centers. This presentation will highlight survey findings, identify challenges of sustaining open repositories for the health sciences community, and pinpoint trends in the medical and non-medical IR landscape. Problem: The purpose of the authors’ research study is to establish a snapshot view of the institutional repository landscape specific to medical schools and academic health centers. We hope to gain a deeper understanding of the role, characteristics, and future plans of IRs in this setting, and share these findings with the wider repository community. Approach: We submitted a 21-question REDCap survey to the member libraries of the Association of Academic Health Sciences Libraries (AAHSL). AAHSL was chosen as the survey group because its member libraries serve the accredited U.S. and Canadian medical schools belonging to the Association of American Medical Colleges (AAMC). The survey opened on December 7, 2017, with data collection to continue through January 8, 2018. Conclusions: Results will be analyzed in early 2018 and findings will be highlighted in this presentation

Lenient multi-agent deep reinforcement learning

Much of the success of single agent deep reinforcement learning (DRL) in recent years can be attributed to the use of experience replay memories (ERM), which allow Deep Q-Networks (DQNs) to be trained efficiently through sampling stored state transitions. However, care is required when using ERMs for multi-agent deep reinforcement learning (MA-DRL), as stored transitions can become outdated because agents update their policies in parallel [11]. In this work we apply leniency [23] to MA-DRL. Lenient agents map state-action pairs to decaying temperature values that control the amount of leniency applied towards negative policy updates that are sampled from the ERM. This introduces optimism in the value-function update, and has been shown to facilitate cooperation in tabular fully-cooperative multi-agent reinforcement learning problems. We evaluate our Lenient-DQN (LDQN) empirically against the related Hysteretic-DQN (HDQN) algorithm [22] as well as a modified version we call scheduled-HDQN, that uses average reward learning near terminal states. Evaluations take place in extended variations of the Coordinated Multi-Agent Object Transportation Problem (CMOTP) [8] which include fully-cooperative sub-tasks and stochastic rewards. We find that LDQN agents are more likely to converge to the optimal policy in a stochastic reward CMOTP compared to standard and scheduled-HDQN agents

Crystal structure of hexa-μ-chlorido-μ4-oxido-tetrakis{[1-(2-hydroxyethyl)-2- methyl-5-nitro-1H-imidazole-κN3]copper(II)} containing short NO2· · ·NO2 contacts

The title tetranuclear copper complex, [Cu4Cl6O(C6H9N3O3)4] or [Cu4Cl6O- (MET)4][MET is 1-(2-hydroxyethyl)-2-methyl-5-nitro-1Η-imidazole or metronidazole], contains a tetrahedral arrangement of copper(II) ions. Each copper atom is also linked to the other three copper atoms in the tetrahedron via bridging chloride ions. A fifth coordination position on each metal atom is occupied by a nitrogen atom of the monodentate MET ligand. The result is a distorted CuCl3NO trigonal–bipyramidal coordination polyhedron with the axial positions occupied by oxygen and nitrogen atoms. The extended structure displays O− H ⋅ ⋅ ⋅O hydrogen bonding, as well as unusual short O⋅ ⋅ ⋅ N interactions [2.775 (4) A ˚ ] between the nitro groups of adjacent clusters that are oriented perpendicular to each other. The scattering contribution of disordered water and methanol solvent molecules was removed using the SQUEEZE procedure [Spek (2015). Acta Cryst. C71, 9–16] in PLATON [Spek (2009). Acta Cryst. D65, 148–155]

Multi-label prediction for political text-as-data

Political scientists increasingly use supervised machine learning to code multiple relevant labels from a single set of texts. The current "best practice"of individually applying supervised machine learning to each label ignores information on inter-label association(s), and is likely to under-perform as a result. We introduce multi-label prediction as a solution to this problem. After reviewing the multi-label prediction framework, we apply it to code multiple features of (i) access to information requests made to the Mexican government and (ii) country-year human rights reports. We find that multi-label prediction outperforms standard supervised learning approaches, even in instances where the correlations among one's multiple labels are low

Carboxy-terminal Determinants of Conductance in Inward-rectifier K Channels

Previous studies suggested that the cytoplasmic COOH-terminal portions of inward rectifier K channels could contribute significant resistance barriers to ion flow. To explore this question further, we exchanged portions of the COOH termini of ROMK2 (Kir1.1b) and IRK1 (Kir2.1) and measured the resulting single-channel conductances. Replacing the entire COOH terminus of ROMK2 with that of IRK1 decreased the chord conductance at Vm = −100 mV from 34 to 21 pS. The slope conductance measured between −60 and −140 mV was also reduced from 43 to 31 pS. Analysis of chimeric channels suggested that a region between residues 232 and 275 of ROMK2 contributes to this effect. Within this region, the point mutant ROMK2 N240R, in which a single amino acid was exchanged for the corresponding residue of IRK1, reduced the slope conductance to 30 pS and the chord conductance to 22 pS, mimicking the effects of replacing the entire COOH terminus. This mutant had gating and rectification properties indistinguishable from those of the wild-type, suggesting that the structure of the protein was not grossly altered. The N240R mutation did not affect block of the channel by Ba2+, suggesting that the selectivity filter was not strongly affected by the mutation, nor did it change the sensitivity to intracellular pH. To test whether the decrease in conductance was independent of the selectivity filter we made the same mutation in the background of mutations in the pore region of the channel that increased single-channel conductance. The effects were similar to those predicted for two independent resistors arranged in series. The mutation increased conductance ratio for Tl+:K+, accounting for previous observations that the COOH terminus contributed to ion selectivity. Mapping the location onto the crystal structure of the cytoplasmic parts of GIRK1 indicated that position 240 lines the inner wall of this pore and affects the net charge on this surface. This provides a possible structural basis for the observed changes in conductance, and suggests that this element of the channel protein forms a rate-limiting barrier for K+ transport