The Association between Critical Thinking and Scholastic Aptitude on First-time Pass Rate of the National Physical Therapy Examination

Objectives: 1) To investigate the relationships among critical thinking (CT) abilities, overall academic performance in the Doctorate of Physical Therapy (DPT) program as measured by cumulative grade point average (GPA), and National Physical Therapy Examination (NPTE) licensure scores, and 2) To determine if NPTE scores were significantly different between groups of students who were classified as having low, moderate or high CT abilities. Background: It is well-established that physical therapy practice requires good clinical reasoning skills. Passage of the NPTE is required for licensure. Research to date has been mixed as to whether CT abilities or GPA can predict success on national board licensure examinations such as the NPTE. The conflicting results may be partially due to weak research methodologies, uncontrolled confounders, and the use of non-standardized assessment instruments. Methods and Measures: A convenience sample of 91 DPT students completed a standard assessment of CT abilities three times. Repeated measure (RM) general linear model (GLM) tests were run to determine if mean California Critical Thinking Skills Test (CCTST) scores changed significantly over the course of the DPT program. A Pearson’s correlation matrix was constructed to investigate the relationships among NPTE scores, GPA, and CT. A univariate GLM test was run to determine if there was a statistically significant difference in mean NPTE scores between low, medium, and high CCTST groups. Results: Complete sets of the three CCTST scores were available for 69 students, and NPTE scores were available for 73 graduates. The strongest correlation with the first-time NPTE score was the GPA (r = 0.735, p = 0.001), followed by the CCTST score at Measurement 1 (r = 0.413, p = 0.0001). Graduates who were classified as having low CT abilities had a 100% failure rate on the first attempt for the NPTE, and scored significantly lower on the exam compared to graduates with moderate or high CT abilities (615.33, 634.6, and 652.43, respectively p = 0.0005). Conclusion: Implementing pedagogical practices that foster CT abilities and/or using a CCTST score of 18 or greater as DPT program entry criterion may equate to greater first-time NPTE pass rates for program graduates

Schur functions and their realizations in the slice hyperholomorphic setting

we start the study of Schur analysis in the quaternionic setting using the theory of slice hyperholomorphic functions. The novelty of our approach is that slice hyperholomorphic functions allows to write realizations in terms of a suitable resolvent, the so called S-resolvent operator and to extend several results that hold in the complex case to the quaternionic case. We discuss reproducing kernels, positive definite functions in this setting and we show how they can be obtained in our setting using the extension operator and the slice regular product. We define Schur multipliers, and find their co-isometric realization in terms of the associated de Branges-Rovnyak space

Breast cancer stem cells: tools and models to rely on

There is increasing evidence for the "cancer stem cell (CSC) hypothesis", which holds that cancers are driven by a cellular component that has stem cell properties, including self-renewal, tumorigenicity and multi-lineage differentiation capacity. Researchers and oncologists see in this model an explanation as to why cancer may be so difficult to cure, as well as a promising ground for novel therapeutic strategies. Given the specific stem cell features of self-renewal and differentiation, which drive tumorigenesis and contribute to cellular heterogeneity, each marker and assay designed to isolate and characterize CSCs has to be functionally validated. In this review, we survey tools and markers available or promising to identify breast CSCs. We review the main models used to study breast CSCs and how they challenge the CSC hypothesis

Epigenetic polypharmacology: from combination therapy to multitargeted drugs

The modern drug discovery process has largely focused its attention in the so-called magic bullets, single chemical entities that exhibit high selectivity and potency for a particular target. This approach was based on the assumption that the deregulation of a protein was causally linked to a disease state, and the pharmacological intervention through inhibition of the deregulated target was able to restore normal cell function. However, the use of cocktails or multicomponent drugs to address several targets simultaneously is also popular to treat multifactorial diseases such as cancer and neurological disorders. We review the state of the art with such combinations that have an epigenetic target as one of their mechanisms of action. Epigenetic drug discovery is a rapidly advancing field, and drugs targeting epigenetic enzymes are in the clinic for the treatment of hematological cancers. Approved and experimental epigenetic drugs are undergoing clinical trials in combination with other therapeutic agents via fused or linked pharmacophores in order to benefit from synergistic effects of polypharmacology. In addition, ligands are being discovered which, as single chemical entities, are able to modulate multiple epigenetic targets simultaneously (multitarget epigenetic drugs). These multiple ligands should in principle have a lower risk of drug-drug interactions and drug resistance compared to cocktails or multicomponent drugs. This new generation may rival the so-called magic bullets in the treatment of diseases that arise as a consequence of the deregulation of multiple signaling pathways provided the challenge of optimization of the activities shown by the pharmacophores with the different targets is addressed

An American National Corpus: A Proposal

This paper proposes the development of an American National Corpus comparable to the British National Corpus. Corpus-analytic work has demonstrated that the use of the British National Corpus is inappropriate to study of American English, due to the numerous differences in the use of the language. We also propose that the corpus include a component of texts in other major North American languages, notably Spanish and French, and ideally a parallel component containing texts in these languages aligned to the English. The development of an ANC will demand a significant commitment from the funding agencies and the research community; such an effort would, however, significantly contribute to language and linguistic research as well as the U.S. National Digital Libraries Initiative and other large-scale projects. 1. Introduction The need for large-scale corpus resources for natural language and speech research is well established. Such resources are becoming increasingly available through..

Simulated Driving Performance of Adults With ADHD: Comparisons With Alcohol Intoxication

Previous research has demonstrated that adults with attention deficit/hyperactivity disorder (ADHD) are more likely to experience driving-related problems, which suggests that they may exhibit poorer driving performance. However, direct experimental evidence of this hypothesis is limited. The current study involved 2 experiments that evaluated driving performance in adults with ADHD in terms of the types of driving decrements typically associated with alcohol intoxication. Experiment 1 compared the simulated driving performance of 15 adults with ADHD to 23 adult control participants, who performed the task both while sober and intoxicated. Results showed that sober adults with ADHD exhibited decrements in driving performance compared to sober controls, and that the profile of impairment for the sober ADHD group did in fact resemble that of intoxicated drivers at the blood alcohol concentration level for legally impaired driving in the United States. Driving impairment of the intoxicated individuals was characterized by greater deviation of lane position, faster and more abrupt steering maneuvers, and increased speed variability. Experiment 2 was a dose-challenge study in which 8 adults with ADHD and 8 controls performed the driving simulation task under 3 doses of alcohol: 0.65g/kg, 0.45g/kg, and 0.0g/kg (placebo). Results showed that driving performance in both groups was impaired in response to alcohol, and that individuals with ADHD exhibited generally poorer driving performance than did controls across all dose conditions. Together the findings provide compelling evidence to suggest that the cognitive and behavioral deficits associated with ADHD might impair driving performance in such a manner as to resemble that of an alcohol intoxicated driver. Moreover, alcohol might impair the performance of drivers with ADHD in an additive fashion that could considerably compromise their driving skill even at blood alcohol concentrations below the legal limit