Possible ways to improve the comfort, fit and visual performance of swimming goggles

The primary aim of this thesis was to provide a comprehensive evaluation of the human face so that it can be used to improve the design of swimming goggles with regards to comfort and fit. The secondary aim was concerned with vision and was to identify whether a curved lens could be plausible for use in a performance racing goggle. [Continues.

The Identification of Antibiotic-Producing Bacillus from Soil

One of the largest issues facing the scientific and medical communities today is antibacterial resistance. It is important that we continue to discover and develop new antibiotics to keep up with the rapidly adapting bacteria that could potentially cause a wide scale pandemic. The purpose of this study is to identify new antibiotic producing bacteria as well as familiarize ourselves with the practices and procedures that industry professionals use. This project is a collaboration with the Tiny Earth Project Initiative (TEPI), which is a global network of educators and students focused on student sourcing antibiotic discovery from soil. We were able to isolate potential antibiotic producers. They were determined to potentially be a Bacillus strain

A Rigorous Free-form Lens Model of Abell 2744 to Meet the Hubble Frontier Fields Challenge

Hubble Frontier Fields (HFF) imaging of the most powerful lensing clusters provides access to the most magnified distant galaxies. The challenge is to construct lens models capable of describing these complex massive, merging clusters so that individual lensed systems can be reliably identified and their intrinsic properties accurately derived. We apply the free-form lensing method (WSLAP+) to A2744, providing a model independent map of the cluster mass, magnification, and geometric distance estimates to multiply-lensed sources. We solve simultaneously for a smooth cluster component on a pixel grid, together with local deflections by the cluster member galaxies. Combining model prediction with photometric redshift measurements, we correct and complete several systems recently claimed, and identify 4 new systems - totalling 65 images of 21 systems spanning a redshift range of 1.4<z<9.8. The reconstructed mass shows small enhancements in the directions where significant amounts of hot plasma can be seen in X-ray. We compare photometric redshifts with "geometric redshifts", finding a high level of self-consistency. We find excellent agreement between predicted and observed fluxes - with a best-fit slope of 0.999+-0.013 and an RMS of ~0.25 mag, demonstrating that our magnification correction of the lensed background galaxies is very reliable. Intriguingly, few multiply-lensed galaxies are detected beyond z~7.0, despite the high magnification and the limiting redshift of z~11.5 permitted by the HFF filters. With the additional HFF clusters we can better examine the plausibility of any pronounced high-z deficit, with potentially important implications for the reionization epoch and the nature of dark matter.Comment: Accepted for publication in ApJ with newly identified lensed images in complete HFF dat

A Free-Form Prediction for the Reappearance of Supernova Refsdal in the Hubble Frontier Fields Cluster MACSJ1149.5+2223

The massive cluster MACSJ1149.5+2223(z=0.544) displays five very large lensed images of a well resolved spiral galaxy at $z_{\rm spect}=1.491$. It is within one of these images that the first example of a multiply-lensed supernova has been detected recently as part of the Grism Lens-Amplified Survey from Space. The depth of this data also reveals many HII regions within the lensed spiral galaxy which we identify between the five counter-images. Here we expand the capability of our free-form method to incorporate these HII regions locally, with other reliable lensed galaxies added for a global solution. This improved accuracy allows us to estimate when the Refsdal supernova will appear within the other lensed images of the spiral galaxy to an accuracy of $\sim$ 7\%. We predict this supernova will reappear in one of the counter-images (RA=11:49:36.025, DEC=+22:23:48.11, J2000) and on November 1$^{st}$ 2015 (with an estimated error of $\pm$ 25 days) it will be at the same phase as it was when it was originally discovered, offering a unique opportunity to study the early phases of this supernova and to examine the consistency of the mass model and the cosmological model that have an impact on the time delay prediction.Comment: 12 images, 11 pages. Mateches accepted version in MNRAS. MNRAS in pres

Food Stamp Participation and Reasons for Nonparticipation: 1986

The decision of eligible households to participate in the food stamp program is analyzed utilizing the 1986 Panel Study of Income Dynamics. Less than one-half of the sample of eligible households receive food stamps in 1986. The results of a multinomial logit model suggest that participation is related negatively to the age and educational level of the household head and positively to the benefit level. Participation is lower for single men and households residing in the West and higher for people with disabilities and households receiving some form of public transfer income. Problems regarding information about food stamps and personal attitudes toward food stamp use have the greatest impact on the decision to participate.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44658/1/10834_2004_Article_418066.pd

Clinical decision support improves physician guideline adherence for laboratory monitoring of chronic kidney disease: a matched cohort study

Sample graph page of relevant test results. (PDF 289 kb

The Nature of Blue Cores in Spheroids: a Possible Connection with AGN and Star Formation

We investigate the physical nature of blue cores in early-type galaxies through the first multi-wavelength analysis of a serendipitously discovered field blue-nucleated spheroid in the background of the deep ACS/WFC griz multicolor observations of the cluster Abell 1689. The resolved g-r, r-i and i-z color maps reveal a prominent blue core identifying this galaxy as a ``typical'' case study, exhibiting variations of 0.5-1.0 mag in color between the center and the outer regions, opposite to the expectations of reddened metallicity induced gradients in passively evolved ellipticals. From a Magellan-Clay spectrum we secure the galaxy redshift at $z=0.624$. We find a strong X-ray source coincident with the spheroid galaxy. Spectral features and a high X-ray luminosity indicate the presence of an AGN in the galaxy. However, a comparison of the X-ray luminosity to a sample derived from the Chandra Deep Field South displays Lx to be comparable to Type I/QSO galaxies while the optical flux is consistent with a normal star-forming galaxy. We conclude that the galaxy's non-thermal component dominates at high-energy wavelengths while we associate the spheroid blue light with the stellar spectrum of normal star-forming galaxies. We argue about a probable association between the presence of blue cores in spheroids and AGN activity.Comment: Accepted for publication in the Astrophysical Journal. 6 pages, 3 figures. Full resolution images available at http://acs.pha.jhu.edu/~felipe/e-print

Prevalence of drug-drug interactions in oncology patients enrolled on National Clinical Trials Network oncology clinical trials

Abstract Background Drug-drug interactions (DDIs) in subjects enrolling in clinical trials can impact not only safety of the patient but also study drug outcomes and data validity. This makes it critical to adequately screen and manage DDIs. The study objective was to determine the prevalence of DDIs involving study medications in subjects enrolling in National Clinical Trials Network (NCTN) clinical trials at a single institution. DDIs were evaluated based on study protocol recommendations for concomitant medication use (i.e. exclude, avoid or use caution), screening via DDI tool, and pharmacist review. Methods Subjects enrolled in NCTN trials of commercially available agents between January 2013 and August 2017 were included if a complete medication list was available. Complete medication lists were collected from the date of enrollment or the next available date then screened utilizing protocol guidance and the DDI screening tool, Lexicomp® Drug Interactions (Wolters Kluwer, Hudson, OH). Interactions were reviewed for clinical relevance: defined as a DDI that would require a medication change to ensure study agent safety and efficacy at enrollment. Results One hundred and twenty-eight subjects enrolled in 35 clinical trials were included. Protocol guidance detected 15 unique DDI pairs that should be avoided or used with caution in 10.2% (13/128) of subjects. The majority of these subjects did not have a clinically relevant DDI (69.2%, 9/13) based on pharmacist review. Lexicomp® detected moderate to major DDIs in 24.2% (31/128) of subjects, with 9.4% (12/128) having a clinically relevant DDI. Conclusions This study confirms a high prevalence of DDIs present in subjects enrolling in oncology clinical trials. Further efforts should be made to improve methods to detect and manage DDIs in patients enrolling on clinical trials to ensure patient safety and trial data validity.https://deepblue.lib.umich.edu/bitstream/2027.42/146516/1/12885_2018_Article_5076.pd